A5025894400- Sepsis Diagnosis and Treatment
- Antibiotics Pharmacokinetics and Efficacy
- Traumatic Brain Injury and Neurovascular Disturbances
- COVID-19 Clinical Research Studies
- Intensive Care Unit Cognitive Disorders
- Cardiac Arrest and Resuscitation
- Acute Kidney Injury Research
- Respiratory Support and Mechanisms
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Pneumonia and Respiratory Infections
- Long-Term Effects of COVID-19
- Vitamin C and Antioxidants Research
- Nosocomial Infections in ICU
- Cardiac, Anesthesia and Surgical Outcomes
- Clinical Nutrition and Gastroenterology
- Venous Thromboembolism Diagnosis and Management
- Therapeutic Uses of Natural Elements
- S100 Proteins and Annexins
- Pharmacological Effects of Natural Compounds
- Nutrition and Health in Aging
- Cardiac electrophysiology and arrhythmias
- Magnesium in Health and Disease
- SARS-CoV-2 and COVID-19 Research
- Blood transfusion and management
- Renal function and acid-base balance
Smile Train
2024
Sina Hospital
2013-2023
Tehran University of Medical Sciences
2013-2023
University of Zanjan
2023
Polish Mother’s Memorial Hospital Research Institute
2021
University of Tehran
2005-2021
University of California, Los Angeles
2020
University of Ilorin Teaching Hospital
2014
Rasool Akram Hospital
2013
Thrombotic events are commonly reported in critically ill patients with COVID-19. Limited data exist to guide the intensity of antithrombotic prophylaxis.To evaluate effects intermediate-dose vs standard-dose prophylactic anticoagulation among COVID-19 admitted intensive care unit (ICU).Multicenter randomized trial a 2 × factorial design performed 10 academic centers Iran comparing (first hypothesis) and statin therapy matching placebo (second hypothesis; not this article) adult ICU Patients...
The efficacy and safety of transplanting autologous mesenchymal stem cells (MSCs), from granulocyte-colony-stimulating factor (G-CSF)-mobilised peripheral blood, was investigated in diabetic patients with critical limb ischaemia (CLI). After 3 months, the transplanted group (n=7) showed a significant improvement manifestations, including pain neurological signs, wound healing rate lower-limb amputation, compared to control (n=14). Pain significantly reduced controls (P=0.014)....
Sepsis and septic shock is characterized by oxidative stress that mainly promotes systemic inflammation organ failure due to excessive free radical production depletion of antioxidant defenses. Therefore, we investigated the effect selenium administration on status, levels cytokines clinical outcomes.This study was a prospective randomized control trial (RCT) whereby patients received as sodium selenite (2 mg IV bolus followed 1.5 continuous infusion for 14 days) plus standard therapy. The...
Introduction: Classically, aminoglycosides are known to have low penetration into the lung tissue. So far, no study has been conducted on human adult patients evaluate amikacin concentration in epithelial lining fluid (ELF) of alveoli. Therefore, convincing data not available from perspective pharmacokinetics support fact that a dosage 20 mg/kg is sufficient treat with ventilator-associated pneumonia (VAP). Method: This was pilot measurement alveolar site action critically ill VAP who...
Experimental studies have suggested the beneficial effects of curcuminoids as natural polyphenols against traumatic brain injury (TBI). The aim this study was to investigate supplementation with on inflammatory and oxidative stress biomarkers, clinical outcomes nutritional status in critically ill patients TBI. A total 62 ICU‐admitted adult TBI were randomly allocated receive either a daily dose 500 mg or matched placebo via enteral nutrition for 7 consecutive days based stratified block...
Objective. The aim of our study was to assess and validate the effectiveness early dose adjustment vancomycin based on first monitoring in achieving target recommended goal critically ill patients. Methods. Twenty patients with sepsis received loading 25 mg/kg then were randomly assigned 2 groups. Group 1 maximum empirical doses 15 every 8 hrs. In group 2, individualized serum concentrations vancomycin. First nonsteady state sampling used calculate pharmacokinetic parameters within 24 hours....
Introduction: To achieve target concentrations, the application of higher-than-standard doses amikacin is proposed for treatment sepsis due to an increase in volume distribution and clearance, but little data are available on aminoglycoside administration critically ill elderly patients. Patients methods: Forty patients (aged over 65 years) who required therapy severe documented, or suspected gram-negative infections, were randomly assigned two groups. Group A (20 patients) received 15 mg/kg...
Previous studies have shown a beneficial effect of curcuminoids supplementation on serum concentrations adipokines; however, there are no published that examined this among critically ill patients. We aimed to assess the effects with leptin and adiponectin in patients traumatic brain injury (TBI). In trial, 62 TBI, aged 18–65 years, were randomly allocated receive either 500 mg/day (co‐administered 5 piperine) or matched placebo for 7 days. Patients both intervention groups received routine...
IntroductIonThe incidence of sepsis was high and in the United States it is estimated to be 300/100,000 population per year. [1]The spectrum disease a major cause morbidity mortality globally, with severe ≥5-fold higher than that for acute coronary syndrome or stroke. [2]With advances health-care services technology, appropriate organ support, treatment underlying inciting pathogens, rate still 20%-50%. [3]ring infection, pathogens cellular components are recognized by receptors expressed on...