A5020367352- Acute Myeloid Leukemia Research
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Acute Lymphoblastic Leukemia research
- Immune Cell Function and Interaction
- Viral-associated cancers and disorders
- Retinoids in leukemia and cellular processes
- Lung Cancer Treatments and Mutations
- Protein Degradation and Inhibitors
- Hematopoietic Stem Cell Transplantation
- Platelet Disorders and Treatments
- Blood groups and transfusion
- CNS Lymphoma Diagnosis and Treatment
- Cancer-related gene regulation
- Colorectal Cancer Treatments and Studies
- Ubiquitin and proteasome pathways
- Neuroblastoma Research and Treatments
- Adipose Tissue and Metabolism
- Eosinophilic Disorders and Syndromes
- Lung Cancer Research Studies
- Complement system in diseases
- Antifungal resistance and susceptibility
- Sinusitis and nasal conditions
- Myeloproliferative Neoplasms: Diagnosis and Treatment
University of Tsukuba
2006-2020
Eli Lilly (Japan)
2017-2019
University of Tsukuba Hospital
2014-2015
The University of Tokyo
2011-2014
Frederick National Laboratory for Cancer Research
2002
National Cancer Institute
2002
Science Applications International Corporation (United States)
2000-2001
National Institutes of Health
2001
National Cancer Centre Japan
1996-2000
National Cancer Research Institute
1997
Nerve growth factor (NGF) stimulation of pheochromocytoma PC12 cells transiently increased the intracellular concentration reactive oxygen species (ROS). This increase was blocked by chemical antioxidant N-acetylcysteine and a flavoprotein inhibitor, diphenylene iodonium. NGF responses cells, including neurite outgrowth, tyrosine phosphorylation, AP-1 activation, inhibited when ROS production prevented byN-acetylcysteine The expression dominant negative Rac1N17 induction both generation...
TET2 (Ten Eleven Translocation 2) is a dioxygenase that converts methylcytosine (mC) to hydroxymethylcytosine (hmC). loss-of-function mutations are highly frequent in subtypes of T-cell lymphoma harbor follicular helper T (Tfh)-cell-like features, such as angioimmunoblastic (30–83%) or peripheral lymphoma, not otherwise specified (10–49%), well myeloid malignancies. Here, we show middle-aged Tet2 knockdown (Tet2gt/gt) mice exhibit Tfh-like cell overproduction the spleen compared with control...
Chronic rhinosinusitis with nasal polyps is generally characterized by local Th2 inflammation and categorized into two subtypes in Japan: eosinophilic chronic (similar to western countries) non-eosinophilic (characterized Th1-dominant inflammation).To investigate IgE production class switch recombination these of polyps.The identity IgE-positive cells was determined using double-immunofluorescent staining for cell-type-specific molecular markers. To the synthesis mucosa, we performed...
This open-label, multicenter, phase 1b/2 study assessed necitumumab plus gemcitabine and cisplatin (GC + N) in patients with previously untreated squamous non-small cell lung cancer Japan.The 1b part determined the dose for 2 part, which were randomized 1:1 to GC N or (GC) (gemcitabine 1250 mg/m2 on days 1 8; 75 day of maximum four 3-week cycles; nectimumab 800 mg 8 a cycle continued until progressive disease unacceptable toxicity). The primary endpoint was overall survival.In 181 received...
ABSTRACT Follicular lymphoma (FL) is the second most common subtype of non‐Hodgkin (NHL) in Japan, United States, and Western Europe. Parsaclisib a potent, selective next‐generation PI3Kδ inhibitor that has demonstrated clinical efficacy tolerability phase II studies patients with relapsed or refractory (R/R) B‐cell NHL, including FL. We report results from CITADEL‐213 (NCT04434937), study evaluating safety parsaclisib Japanese R/R Eligible were aged ≥ 18 years histologically confirmed FL...
Axatilimab, an anti-colony-stimulating factor 1 receptor (CSF-1R) antibody, blocks colony-stimulating (CSF-1) and interleukin-34 (IL-34) binding to CSF-1R on macrophages monocytes. Axatilimab has demonstrated efficacy safety in chronic graft-versus-host disease, its safety, pharmacokinetics (PK), pharmacodynamics (PD) were characterized healthy Western participants. The objective of this study was evaluate the PK, PD axatilimab among Japanese men. In double-blind, randomized, dose-escalation...
The promotion-sensitive mouse epidermal JB6 cells (clone 41) have been used to identify the tumor-promoting activity of various compounds. Because treatment by tumor promoters [12-O-tetradecanoylphorbol-13-acetate (TPA), growth factor (EGF), or necrosis alpha (TNF-alpha)] transforms clone 41 anchorage-independent and tumorigenic phenotypes, they are considered be undergoing late-stage promotion. Here we address question how much activation transformation-relevant transcription factors...
Abstract We have identified a novel fusion partner of MLL , namely the mastermind like 2 ( MAML gene), in secondary acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) with inv(11)(q21q23). RT‐PCR sequencing revealed that exon 7 was fused to AML MDS cells. The inv(11)(q21q23) results creation chimeric RNA encoding putative protein containing 1,408 amino acids from NH2‐terminal part 952 COOH‐terminal MAML2. MAML2, basic domain including binding site intracellular NOTCH, deleted...
A patient with idiopathic thrombocytopenic purpura (ITP) developed T‐cell lymphoma while undergoing steroid therapy. We examined the relationship between patient's serum thrombopoietin (Tpo) level, platelet count, megakaryocyte number and CFU‐Meg during second 5 d course of chemotherapy for in which megakaryopoiesis switched from ITP phase to amegakaryocytic phase. The count was temporarily elevated but numbers were markedly suppressed, decreased this period, whereas Tpo level not suppressed...
Abstract Acute promyelocytic leukemia (APL) is characterized by chromosomal rearrangements of 17q21, leading to fusion the gene‐encoding retinoic acid receptor alpha ( RARA ) with a number alternative partner genes. Signal transducer and activator transcription 5 beta STAT5B one partners. We report rare case APL STAT5B–RARA transcript normal chromosome 17 on G‐banding. Administration all trans ‐retinoic improved disseminated intravascular coagulation without decrease cells in his peripheral...
A novel human myeloid leukaemia cell line (HNT‐34) was established from the peripheral blood of a 45‐year‐old female patient with acute myelogenous (AML) transformed chronic myelomonocytic (CMMoL) 3q21q26 syndrome. Morphologically, HNT‐34 cells were undifferentiated blasts which negative for myeloperoxidase. The positive CD4, CD13, CD33 and CD34, but CD41a CD42b. actively proliferated in suspension doubling time 26–27 h absence any growth factors. Neither proliferative advantage nor...