ConspectusThe integration of a porous crystalline framework with soft polymers to create novel biomaterials has tremendous potential yet remains very challenging date. Metal–organic (MOF)-templated (MTPs) have emerged as persistent modular materials that can be tailored for desired biofunctions. These represent class hierarchically structured assemblies combine the advantages MOFs (precisely controlled structure, enormous diversity in topology, and high porosity) intrinsic behaviors (soft...

Development of surface coatings with high antimicrobial activity is urgently required to fight bacteria and other microorganisms on technical hygiene relevant surfaces. Control over structure topology the coatings, combined ability include functional molecules within structure, crucial for optimizing their performance. Herein, we describe a novel strategy synthesize structurally well-defined porphyrin polymer thin films via template approach. In this approach, bisazido-functionalized are...

Drinking water supplies are now proven to contain pharmaceutical residues, which becoming a huge global problem. Pharmaceutical residues in also responsible for developing drug-resistant superbugs, has emerged as significant threat health. To tackle the above challenges, present manuscript reports development of chitosan-attached gold nanoparticle conjugated graphene oxide architecture-based multifunctional three-dimensional (3D) porous membrane capability effective separation and label-free...

Abstract Porous materials have attracted tremendous scientific and industrial interest due to their broad commercial applicability. However, some applications require that these are deposited on surfaces create thin films. Here, the recent progress of new porous thin‐film material classes is described: organic molecular materials, polymers, covalent frameworks, nanoporous carbon. In each case, state art current barriers in fabrication, as well intrinsic advantages suited for different...

Cesium–lead-halide perovskite quantum dots (PQDs) are a highly promising class of the next-generation optical material for bioimaging applications. Herein, we present nanocomposite strategy design water-soluble, luminescence CsPbBr3 PQD nanocomposites without modifying crystal symmetry and photoluminescence (PL) property. Water-soluble PQDs reproducibly synthesized via encapsulating with polystyrene-block-poly(ethylene-ran-butylene)-block-polystyrene (PS–PEB-PS) poly(ethylene...

Abstract The development of water‐mediated proton‐conducting materials operating above 100 °C remains challenging because the extended structures existing usually deteriorate at high temperatures. A new triazolyl phosphonate metal–organic framework (MOF) [La 3 L 4 (H 2 O) 6 ]Cl ⋅ x H O ( 1 , 2− =4‐(4 ‐1,2,4‐triazol‐4‐yl)phenyl phosphonate) with highly hydrophilic 1D channels was synthesized hydrothermally. Compound is an example a MOF large regular pores 1.9 nm in diameter. It forms...

Abstract The T‐box transcription factor Tbx3 plays multiple roles in normal development and disease. In order to function different tissues on target genes, binds factors or other cofactors specific temporal spatial locations. Examining the of mammary gland, limbs, heart as well biology stem cells cancer provides insights into diverse common functions that can perform. By either repressing activating genes a context‐dependent manner, is able modulate differentiation immature progenitor...

2,4,6-Trinitrotoluene (TNT) forms a red-colored Meisenheimer complex with 3-aminopropyltrenthoxysilane (APTES) both in solution and on solid phase. The TNT-APTES is unique since it yellow-colored complexes 2,4,6-trinitrophenol 4-nitrophenol, no 2,4-dinitrotoluene. absorption spectrum of has two bands at 530 650 nm, while APTES 4-nitrophenol have maxima around 420 change for facilitates the exchange TNT-CH

This feature article describes recent trends and advances in structuring network polymers using a coordination-driven metal-organic framework (MOF)-based template approach to demonstrate the concept of crystal-controlled polymerization confined nanospaces, forming tailored architectures ranging from simple linear one-dimensional macromolecules tunable three-dimensional cross-linked interwoven molecular architectures. MOF-templated combine characteristics advantages crystalline MOFs (high...

Two-photon absorption (2PA) and three-photon (3PA) processes feature many technological applications for fluorescence microscopy, photodynamic therapy, optical data storage, so on, Herein, we reveal that the giant 2PA 3PA properties all-inorganic CsPbX3 (X = Cl, Br, I, mixed Cl/Br Br/I) perovskite quantum dots (PQDs) can be enhanced several orders of magnitude, respectively, by simply changing halide stoichiometry at X site. Notably, reported show excellent CsPbI3 (σ2 ∼ 2.1 × 106 GM σ3 1.1...

Abstract Function‐inspired design of molecular building blocks for their assembly into complex systems has been an objective in engineering nanostructures and materials modulation at nanoscale. This article summarizes recent research inspiring progress the design/synthesis various custom‐made chiral, switchable, highly responsive construction diverse covalent/noncovalent assemblies with tailored topologies, properties, functions. Illustrating judicious selection blocks, orthogonal...

Abstract Active nuclear import of Ran exchange factor RCC1 is mediated by importin α3. This pathway essential to generate a gradient RanGTP on chromatin that directs nucleocytoplasmic transport, mitotic spindle assembly and envelope formation. Here we identify the mechanisms α3 selectivity for RCC1. We find this isoform binds with one order magnitude higher affinity than generic α1, although two isoforms share an identical NLS-binding groove. Importin uses its greater conformational...

Near-infrared (NIR) light between 700 and 2500 nm, which is in the range of first, second, third biological windows, has capability to penetrate tissues blood, provides a huge advantages higher penetration depth. However, because lack available biocompatible single photon probes NIR window, there an urgent need for new theranostic material, could be used two-photon bioimaging as well photodynamic therapy (PDT) window. Driven by need, current manuscript reports gold nanoclusters (GNCs)...

The emergence of antibiotic-resistant bacteria is the biggest threat to our society. rapid discovery drug resistant very urgently needed guide antibiotic treatment development. current manuscript reports design a 2D-0D heterostructure-based surface enhanced Raman spectroscopy (SERS) platform, which has capability for identification multidrug strain Salmonella DT104. Details synthesis and characterization heterostructure SERS platform using two dimensional (2D) WS2 transition metal...

According to the World Health Organization, more than two billion people in our world use drinking water sources which are not free from pathogens and heavy metal contamination. Unsafe is responsible for death of several millions 21st century. To find facile cost-effective routes developing multifunctional materials, has capability resolve many challenges associated with problem, here, we report novel design fluorescence-magnetic biochar highly efficient separation, identification, removal...

Development of new antibacterial therapeutic materials is becoming increasingly urgent due to the huge threat superbugs, which are responsible for more than half a million deaths each year in this world. Here, we report development novel nanobiomaterial based on melittin antimicrobial peptide (AMP)-attached transition metal dichalcogenide MoS2-based theranostic nanoplatform. The reported nanoplatform has capability targeted identification and synergistic inactivation 100% multidrug-resistant...

The new microporous cobalt triazolyl phosphonate MOF3α [Co4L3(μ3-OH)(H2O)3](SO4)0.5·xH2O (L(2-) = 4-(4H-1,2,4-triazol-4-yl)-phenyl phosphonate) exhibits exciting features including high water stability, reversible hydration-dehydration, steep uptake in repeated cycles at low vapor pressures and reactivation room temperature under mild evacuation.

The ability to control the structure and topology of polymer networks, both on macroscopic molecular levels, is crucial for optimizing their performance. Here we describe a novel type network polymer, which synthesized via conversion highly ordered metal–organic framework (MOF) template into gel. synthesis performed using light-induced metal-free thiol–ene click chemistry. use light-triggered reactions in combination with photomasks or other photopatterning techniques allows reaction be...

The World Health Organization (WHO) estimates that 30% people in the world lack access to safe drinking water due presence of toxic waterborne contaminants, which kills more than 7.6 million children every year. Marine mussels secure themselves environment via foot proteins containing 3,4-dihydroxy-l-phenylalanine (DOPA) and lysine amino acids. Inspired by mussel surface chemistry, current paper, we report development novel composite nanoparticles functionalization polydopamine nanoparticle...

The mineralocorticoid aldosterone is produced in the adrenal zona glomerulosa (ZG) under control of renin–angiotensin II (AngII) system. Primary aldosteronism (PA) results from renin-independent production and a common cause hypertension. PA caused by dysregulated localization enzyme synthase (Cyp11b2), which normally restricted to ZG. Cyp11b2 transcription are predominantly regulated AngII activation Gq signaling pathway. Here, we report generation transgenic mice with Gq-coupled designer...