A5047359460- Extracellular vesicles in disease
- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- MicroRNA in disease regulation
- Acute Kidney Injury Research
- Neurological Disorders and Treatments
- Cardiac Ischemia and Reperfusion
- Urological Disorders and Treatments
- Kidney Stones and Urolithiasis Treatments
- Body Composition Measurement Techniques
- Trace Elements in Health
- Heavy Metal Exposure and Toxicity
- Alcohol Consumption and Health Effects
- Clinical Nutrition and Gastroenterology
- Fatty Acid Research and Health
- Pesticide and Herbicide Environmental Studies
- Ion channel regulation and function
- Inflammasome and immune disorders
- Circular RNAs in diseases
- Iron Metabolism and Disorders
- Nitric Oxide and Endothelin Effects
- Eicosanoids and Hypertension Pharmacology
Universidade Federal de São Paulo
2011-2024
TGF-β1 is the main mediator of epithelial-to-mesenchymal transition (EMT). Hyperoxaluria induces crystalluria, interstitial fibrosis, and progressive renal failure. This study analyzed whether hyperoxaluria associated with production kidney fibrosis in mice if oxalate or calcium (CaOx) could induce EMT proximal tubule cells (HK2) therefore contribute to fibrotic process. was induced by adding hydroxyproline ethylene glycol mice's drinking water for up 60 days. Renal function urinary crystals...
Abstract One important concern in the treatment of diabetes is maintenance glycemic levels and prevention diabetic nephropathy. Inducible heme oxygenase 1 (HO-1) a rate-limiting enzyme thought to have antioxidant cytoprotective roles. The goal present study was analyze effect HO-1 induction chronically hyperglycemic rats. rats were divided into two groups: one group, called STZ, given single injection streptozotocin; other group streptozotocin as well daily injections hemin, an inducer, over...
Nephrotoxicity is the main side effect of antibiotics such as gentamicin. Preconditioning has been reported to protect against injuries ischemia/reperfusion. The objective present study was determine preconditioning with gentamicin on LLC-PK1 cells. induced in cells by 24-h exposure 2.0 mM (G/IU). After 4 or 15 days preconditioning, were again exposed (2.0 mM) and compared untreated control G/IU Necrosis apoptosis assessed acridine orange HOESCHT 33346. Nitric oxide (NO) endothelin-1 Griess...
Several studies have demonstrated an important association between altered lipid metabolism and the development of kidney injury because a high-fat diet. Fructose is also closely associated with renal injury. We opted for combination fructose saturated fats in diet (DH) that model known to induce damage order evaluate whether soy isoflavones could promising use treatment alterations. After two months ingestion, there was expansion visceral fat, which long-term metabolic disorders, such as...
Umbilical cord mesenchymal stem cell-derived extracellular vesicles (UC-EVs) are valuable in nanomedicine as natural nanocarriers, carrying information molecules from their parent cells and fusing with targeted cells. miRNA-126, specific to endothelial derived these vesicles, supports vascular integrity angiogenesis has protective effects kidney diseases.
// Marcia Convento 1 , Edson Pessoa Alef Aragão 2 Nestor Schor and Fernanda Borges 1, Nephrology Division, Department of Medicine, Federal University São Paulo, SP, Brazil Interdisciplinary Postgraduate Program in Health Sciences, Universidade Cruzeiro do Sul, Correspondence to: Convento, email: convento@unifesp.br Keywords: epithelial to mesenchymal transition; osteogenic differentiation; oxalate; TGF-β1; renal medulla Received: July 25, 2018 ...
Hypotension, increased production of reactive oxygen species, and inflammation are all observed in experimental models sepsis induced by lipopolysaccharide (LPS).The aim this study was to evaluate the effects an ethanolic extract Brazilian olive leaf (Ex), oil (Olv), Ex + Olv (ExOlv), palm (Pal) comparison omega-3 fish (Omg) a rat model sepsis-induced acute kidney injury.Wistar rats were divided into seven groups (seven per group), which either untreated (control) or treated with LPS, LPS...
Mesenchymal stromal cells (MSCs) obtained from bone marrow are a promising tool for regenerative medicine, including kidney diseases. A step forward in MSCs studies is cellular conditioning through specific minerals and vitamins. The Omega-3 fatty acids (ω3) essential regulating self-renewal, cell cycle, survival. ω3 could act as ligand peroxisome proliferator-activated receptor gamma (PPAR-γ). This study aimed to demonstrate that supplementation rats lead the up-regulation of PPAR-γ MSCs....
Abstract: Containing information molecules from their parent cells and inclining to fuse with targeted cells, bone marrow mesenchymal stromal cells-derived extracellular vesicles (MSCs- EV) are valuable in nanomedicine. Background: The effects of aging on the paracrine mechanism production action MSCs-EV cargos miR-26a siRNA-26a for treatment tubular renal under nephrotoxicity injury remain unelucidated. Objective: purpose this study was evaluate different ages ability deliver siRNA-26ª...
Abstract Introduction: Glyphosate is the most widely used herbicide worldwide and in Brazil. There currently increasing concern about effects of glyphosate on human health. The Brazilian Institute for Consumer Protection showed data presence some Brazil’s consumed ultra-processed products. Currently, regulations upper limit these residues foods have yet to be established by National Health Surveillance, food consumption independently associated with an increased risk incident chronic kidney...
RESUMO Introdução: O glifosato é o herbicida mais utilizado no mundo e Brasil. Atualmente, há uma preocupação crescente com os efeitos do na saúde humana. Instituto Brasileiro de Defesa Consumidor apresentou dados sobre a presença em alguns dos produtos ultraprocessados consumidos as regulamentações limite máximo desses resíduos alimentos ainda não foram estabelecidas pela Vigilância Sanitária Nacional, consumo está independentemente associado um risco maior doença renal crônica incidente....
ABSTRACT Hypertension and Diabetes mellitus are the two main causes of chronic kidney disease that culminate in final stage disease. Since these risk factors common can overlap, new approaches to prevent or treat them needed. Macitentan (MAC) is a non-selective antagonist endothelin-1 (ET-1) receptor. This study aimed evaluate effect blockade ET-1 receptor with MAC on alteration renal function observed hypertensive hyperglycemic animals. Genetically rats were divided into control (HT-CTL)...