A5069192572- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Photochromic and Fluorescence Chemistry
- Photoreceptor and optogenetics research
- Enzyme function and inhibition
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Metabolomics and Mass Spectrometry Studies
- Mitochondrial Function and Pathology
- Metal-Organic Frameworks: Synthesis and Applications
- Nanoplatforms for cancer theranostics
- Sulfur Compounds in Biology
- Covalent Organic Framework Applications
- Radical Photochemical Reactions
- Carbon dioxide utilization in catalysis
- Crystallography and molecular interactions
- Sulfur-Based Synthesis Techniques
- Photodynamic Therapy Research Studies
- ATP Synthase and ATPases Research
- Peptidase Inhibition and Analysis
- Vanadium and Halogenation Chemistry
The University of Texas at Austin
2018-2020
Institute of Genomics and Integrative Biology
2013
Dynamic variations in mitochondrial shape have been related to function. However, tools automatically classify and enumerate shapes are lacking, as systematic studies exploring the relationship of such stress. Here we show that during increased generation reactive oxygen species (mtROS), mitochondria change their from tubular donut or blob forms, which can be computationally quantified. Imaging cells treated with rotenone antimycin, showed time dose-dependent conversion forms donut-shaped...
Two azobenzenesulfonamide molecules with thermally stable cis configurations resulting from fluorination of positions ortho to the azo group are reported that can differentially regulate activity carbonic anhydrase in trans and configurations. These fluorinated probes each use two distinct visible wavelengths (520 410 or 460 nm) for isomerization high photoconversion efficiency. Correspondingly, isomer these systems is highly persistent (as evidenced by structural studies solid solution...
A large-pore version of Mg-CUK-1, a water-stable metal–organic framework (MOF) with 1-D channels, was synthesized in basic water. Mg-CUK-1L has BET surface area 2896 m2 g–1 and shows stark selectivity for CO2 sorption over N2, O2, H2, CH4. It displays reversible, multistep gated below 0.33 atm. The dehydrated single-crystal structure confirms retention the open-channel structure. MOF can be loaded organic molecules by immersion hot melts, providing single crystals suitable X-ray diffraction....
We report two small molecule azobenzenesulfonamide probes, CAP1 and CAP2, capable of photomodulating the activity carbonic anhydrase (CA) on demand. In trans form, CAP azobenzene probes adopt a linear shape, making them suitable for occupying CA active site interacting with Zn2+, thereby inhibiting enzyme activity. Following irradiation either 365 or 410 nm light, isomerize to their cis form. Because change in steric profile, probe exits site, is restored. The isomer can revert back through...
Abstract One‐third of all proteins are estimated to require metals for structural stability and/or catalytic activity. Desthiobiotin probes containing metal binding groups can be used capture metalloproteins with exposed active‐site under mild conditions so as prevent changes in metallation state. The proof‐of‐concept was demonstrated carbonic anhydrase (CA), an open active site, Zn 2+ ‐containing protein. CA targeted by using sulfonamide derivatives. Linkers various lengths and structures...