A5080336383- Toxoplasma gondii Research Studies
- Parasitic Infections and Diagnostics
- Eosinophilic Disorders and Syndromes
University of California, Davis
2020
Giardia lamblia, a widespread parasitic protozoan, attaches to the host gastrointestinal epithelium by using ventral disc, complex microtubule (MT) organelle. The 'cup-like' disc is formed spiral MT array that scaffolds numerous disc-associated proteins (DAPs) and higher-order protein complexes. In interphase, hyperstable has limited dynamics; however, it remains unclear how DAPs confer these properties. To investigate mechanisms of hyperstability, we confirmed disc-specific localization...
Abstract Giardia is a common protistan parasite that causes diarrheal disease worldwide. Motile trophozoites colonize the small intestine, attaching to villi with ventral disc, unique and complex microtubule (MT) organelle. Attachment host epithelium allows resist peristalsis during infection of gastrointestinal tract. Despite our emerging view complexity disc architecture, we are still in very preliminary stages understanding how specific structural elements contribute stability or generate...