Charles Alpren

ORCID: 0000-0001-9939-4561
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About
Contact & Profiles
Research Areas
  • COVID-19 epidemiological studies
  • Viral Infections and Outbreaks Research
  • SARS-CoV-2 and COVID-19 Research
  • COVID-19 Clinical Research Studies
  • COVID-19 and healthcare impacts
  • Global Security and Public Health
  • HIV, Drug Use, Sexual Risk
  • Zoonotic diseases and public health
  • HIV/AIDS Research and Interventions
  • SARS-CoV-2 detection and testing
  • Disaster Response and Management
  • Vaccine Coverage and Hesitancy
  • Syphilis Diagnosis and Treatment
  • Opioid Use Disorder Treatment
  • Homelessness and Social Issues
  • Data-Driven Disease Surveillance
  • Neonatal Health and Biochemistry
  • COVID-19 and Mental Health
  • Child and Adolescent Health
  • HIV, TB, and STIs Epidemiology
  • Global Maternal and Child Health
  • Animal Virus Infections Studies
  • Prenatal Substance Exposure Effects
  • Viral gastroenteritis research and epidemiology
  • Infection Control and Ventilation

Sunshine Hospital
2023

Western Health
2023

Department of Health and Human Services
2020-2022

Center for Surveillance, Epidemiology, and Laboratory Services
2019-2021

Epidemic Intelligence Service
2019-2021

Centers for Disease Control and Prevention
2019-2021

Melbourne Health
2021

Government of Western Australia Department of Health
2021

Boston Public Health Commission
2019-2021

Government of Victoria
2020

Abstract Genomic sequencing has significant potential to inform public health management for SARS-CoV-2. Here we report high-throughput genomics SARS-CoV-2, 80% of cases in Victoria, Australia (population 6.24 million) between 6 January and 14 April 2020 (total 1,333 COVID-19 cases). We integrate epidemiological, genomic phylodynamic data identify clusters impact interventions. The global diversity SARS-CoV-2 is represented, consistent with multiple importations. Seventy-six distinct were...

10.1038/s41467-020-18314-x article EN cc-by Nature Communications 2020-09-01

Objectives. To describe and control an outbreak of HIV infection among people who inject drugs (PWID). Methods. The investigation included diagnosed with during 2015 to 2018 linked 2 cities in northeastern Massachusetts epidemiologically or through molecular analysis. Field activities qualitative interviews regarding service availability risk behaviors. Results. We identified 129 meeting the case definition; 116 (90%) reported injection drug use. Molecular surveillance added 36 cases not...

10.2105/ajph.2019.305366 article EN American Journal of Public Health 2019-11-14

Opioid overdose deaths have increased rapidly in northeastern Massachusetts since 2013, with postmortem fentanyl detection increasing statewide. Molecular data indicate multiple introductions of human immunodeficiency virus (HIV) among persons who inject drugs as well recent and rapid transmission the context some longstanding HIV infections.

10.15585/mmwr.mm6810a6 article EN MMWR Morbidity and Mortality Weekly Report 2019-03-14

BACKGROUND: Whole-genome sequencing of pathogens can improve resolution outbreak clusters and define possible transmission networks. We applied high-throughput genome SARS-CoV-2 to 75% cases in the State Victoria (population 6.24 million) Australia. METHODS: Cases infection were detected through active case finding contact tracing. A dedicated multidisciplinary genomic response team was formed enable rapid integration epidemiological data. Phylodynamic analysis performed assess putative...

10.1101/2020.05.12.20099929 preprint EN cc-by-nc-nd medRxiv (Cold Spring Harbor Laboratory) 2020-05-16

This analysis of notified syphilis cases in Victoria, Australia between 2015 and 2018 shows that the epidemic Victoria has become more generalized, with increases among heterosexual men women residing outer Melbourne suburbs-areas differ from those gay men.

10.1097/olq.0000000000001438 article EN Sexually Transmitted Diseases 2021-04-17

Opioid use disorder and neonatal abstinence syndrome (NAS) increased in Massachusetts from 1999 to 2013 (1,2). In response, 2016, the state passed a law requiring birth hospitals report number of newborns who were exposed controlled substances Department Public Health (MDPH)* by mandating monthly reporting International Classification Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) diagnostic codes related maternal dependence on opioids (F11.20) or benzodiazepines (F13.20)...

10.15585/mmwr.mm6929a2 article EN MMWR Morbidity and Mortality Weekly Report 2020-07-23

Abstract Countries worldwide are experiencing a second wave of coronavirus disease 2019 (COVID-19), which is proving to be difficult control. We describe the combination physical distancing, mandatory mask wearing, movement restrictions, and enhanced test, trace, isolation efforts that can used successfully suppress community transmission zero.

10.1093/cid/ciaa1882 article EN other-oa Clinical Infectious Diseases 2020-12-21

On January 14, 2016, the Sierra Leone Ministry of Health and Sanitation was notified that a buccal swab collected on 12 from deceased female aged 22 years (patient A) in Tonkolili District had tested positive for Ebola virus by reverse transcription-polymerase chain reaction (RT-PCR). The most recent case disease (Ebola) been reported 4 months earlier September 13, 2015 (1), World Organization declared end transmission November 7, (2). Government launched response to prevent further...

10.15585/mmwr.mm6526a4 article EN MMWR Morbidity and Mortality Weekly Report 2016-07-07

Abstract Objective: To evaluate an innovative rural service offering comprehensive primary health care for mental clients. Design: A formative evaluation using mixed methods. Setting: NSW community. Participants: Fifteen providers and 120 adult Intervention: monthly clinic held in a general practice to provide clients of the community team. Main outcome measures: Client utilisation activity data. Provider views effectiveness, possible improvements sustainability. Results: The GP Clinic has...

10.1111/j.1440-1584.2010.01159.x article EN Australian Journal of Rural Health 2010-11-30

Much of our current understanding about novel coronavirus disease 2019 (COVID-19) comes from hospitalised patients. However, the spectrum mild and subclinical has implications for population-level screening control. Forty-nine participants were recruited a group 99 adults repatriated cruise ship with high incidence COVID-19. Respiratory rectal swabs tested by polymerase chain reaction (PCR) severe acute respiratory syndrome 2 (SARS-CoV-2). Sera anti-SARS-CoV-2 antibodies enzyme-linked...

10.1017/s0950268821000315 article EN cc-by-nc-nd Epidemiology and Infection 2021-01-01

Background Health care workers are at increased risk of SARS-CoV-2 infection due to potential exposure patients or staff in health settings. Australian services and experienced intense pressure prepare for respond infections. We summarise national data on worker infections associated outbreaks during 2020. Methods collected aggregated infected facilities from all jurisdictions. working solely residential aged were excluded. Jurisdictions provided the number setting outbreaks, confirmed...

10.33321/cdi.2021.45.57 article EN Communicable Diseases Intelligence 2021-10-27

Abstract Background Accessible and accurate diagnostics are critical to control communicable diseases. Uptake of COVID-19 rapid antigen (RA) testing requires physical financial access tests, knowledge about usage, motivation, ability report results. We sought understand patterns factors associated with RA test uptake in Victoria during a period high caseload, promotion, difficulty accessing PCR testing. hypothesise is indicated by the ratio cases diagnosed (probable) those using (confirmed)...

10.1186/s12889-023-16838-7 article EN cc-by BMC Public Health 2023-10-11

Background Sierra Leone experienced the largest documented epidemic of Ebola Virus Disease in 2014–2015. The government implemented a national tollfree telephone line (1-1-7) for public reporting illness and deaths to improve detection cases. Reporting declined substantially after ended. To inform routine mortality surveillance, we aimed describe trends reported 1-1-7 system quantify people's motivations continue epidemic. Methods First, described monthly number between September 2014 2019....

10.1371/journal.pntd.0008624 article EN public-domain PLoS neglected tropical diseases 2020-08-18

Health care workers are at increased risk of SARS-CoV-2 infection due to potential exposure patients or staff in health settings. Australian services and experienced intense pressure prepare for respond infections. We summarise national data on worker infections associated outbreaks during 2020.We collected aggregated infected facilities from all jurisdictions. working solely residential aged were excluded. Jurisdictions provided the number setting outbreaks, confirmed cases,...

10.33321//cdi.2021.45.57 article EN PubMed 2021-10-28

While it is suspected that some ages were misreported during the 2014-2016 West African Ebola outbreak, an analysis examining age data quality has not been conducted. The study objective was to examine heaping and terminal digit preference as indicators for of collected in Sierra Leone Database (SLED).Age adult patients analyzed within SLED Viral Hemorrhagic Fever (VHF) database laboratory testing dataset by calculating Whipple´s index Myers´s blended index, stratified sex region.Age low...

10.11604/pamj.2020.35.104.20348 article EN cc-by Pan African Medical Journal 2020-04-07

BACKGROUND: A cornerstone of Australia's ability to control COVID-19 has been effective border control, using an extensive supervised quarantine program. However, a rapid recrudescence in cases was observed the state Victoria June 2020. Here, we describe genomic findings that located source this second wave as breach hotel and demonstrate successful elimination for time Australia.METHODS: Genome sequencing performed on all available SARS-CoV-2-positive samples integrated epidemiological...

10.2139/ssrn.3830366 article EN SSRN Electronic Journal 2021-01-01

<h3>Background</h3> The study aims to examine the trends of syphilis infection in Victoria and characteristics notified cases among different population groups stratified by risk geographical distributions. <h3>Methods</h3> We analysed demographic characteristics, notification distribution between 2015 2018. Infectious were categorised into four groups: men who have sex with (MSM), women (heterosexual males), females, (bisexual males). examined staging syphilis, geographic location residence...

10.1136/sextrans-2021-sti.217 article EN Poster presentations 2021-07-01

Although there is no published analysis of surnames and given names used in Sierra Leone, certain are common identical frequently encountered. This makes disease tracking contact tracing difficult. During the Ebola outbreak 2014-2016, deficiencies public health information systems Leone exacerbated data collection difficulties. The study objective was to examine frequency recorded Viral Hemorrhagic Fever database (VHF) component Database (SLED). First were standardized by a Leonean linguist....

10.11604/pamj.2022.43.141.30408 article EN PubMed 2022-01-01
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