A5028493935- Urinary Bladder and Prostate Research
- Prostate Cancer Diagnosis and Treatment
- Air Quality and Health Impacts
- Pelvic floor disorders treatments
- Hormonal and reproductive studies
- Biomarkers in Disease Mechanisms
- Sexual function and dysfunction studies
- Olfactory and Sensory Function Studies
- Gastroesophageal reflux and treatments
- Signaling Pathways in Disease
- Neuroblastoma Research and Treatments
- Climate Change and Health Impacts
- Systemic Sclerosis and Related Diseases
- Cardiovascular Syncope and Autonomic Disorders
- Genomics and Chromatin Dynamics
- Antioxidant Activity and Oxidative Stress
- Plant Pathogens and Resistance
- Cardiovascular Disease and Adiposity
- Cardiac electrophysiology and arrhythmias
- Urinary Tract Infections Management
- CRISPR and Genetic Engineering
- Fatty Acid Research and Health
- Pharmaceutical studies and practices
- Protein Structure and Dynamics
- Receptor Mechanisms and Signaling
GlaxoSmithKline (Spain)
2017-2022
University of Minnesota, Duluth
2020-2021
University of Valparaíso
2019
University of Montana
2009-2015
Individuals who identify as lesbian, gay, bisexual, transgender, queer, and otherwise nonstraight and/or non-cisgender (LGBTQ+) have often not felt welcome or represented in the biology community. Additionally, can present unique challenges for LGBTQ+ students because of relationship between certain topics their identities. Currently, there is no centralized set guidelines to make learning environments more inclusive individuals. Rooted prior literature collective expertise authors members...
Protein phosphorylation plays a central role in creating highly dynamic network of interacting proteins that reads and responds to signals from growth factors the cellular microenvironment. Cells neural crest employ multiple signaling mechanisms control migration differentiation during development. It is known defects these cause neuroblastoma, but how pathways interact govern cell behavior unknown. In phosphoproteomic study neuroblastoma lines fractions, including endosomes...
To prospectively assess the impact of fixed-dose combination (FDC) 5α-reductase inhibitor (5ARI), dutasteride 0.5 mg and α1 -adrenoceptor antagonist, tamsulosin 0.4 (DUT-TAM FDC) therapy on sexual function domain scores in sexually active men with lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH), using Men's Sexual Health Questionnaire (MSHQ).This European Australian double-blind, placebo-controlled, parallel-group study was conducted at 51 centres.age ≥50...
Mexico City (MC) residents exposed to fine particulate matter and endotoxin exhibit inflammation of the olfactory bulb, substantia nigra, vagus nerve. The goal this study was model these endpoints in mice examine neuroprotective effects chocolate. Mice MC air received no treatment or oral dark chocolate were compared clean-air either untreated treated intraperitoneally with endotoxin. Cyclooxygenase-2 (COX-2), interleukin 1 beta (IL-1β), CD14 messenger RNA (mRNA) quantified after 4, 8, 16...
Despite superiority of tamsulosin–dutasteride combination therapy versus monotherapy for lower urinary tract symptoms due to benign prostatic hyperplasia (LUTS/BPH), patients at risk disease progression are often initiated on α-blockers. This study evaluated the impact initiating tamsulosin prior switching immediate using a longitudinal model describing International Prostate Symptom Score (IPSS) trajectories in moderate/severe LUTS/BPH progression. Clinical trial simulations (CTS) were...
Abstract Purpose To evaluate the effect of delayed start combination therapy (CT) with dutasteride 0.5 mg and tamsulosin 0.4 on risk acute urinary retention or benign prostatic hyperplasia (BPH)-related surgery (AUR/S) in patients moderate-to-severe lower tract symptoms (LUTS) at disease progression. Methods Using a time-to-event model based pooled data from 10,238 Phase III/IV trials, clinical trial simulations (CTS) were performed to assess AUR/S up 48 months LUTS/BPH following immediate...
Aims Five-α reductase inhibitor (5ARI) therapy has been associated with sexual dysfunction in some patients. This study assessed the impact of a fixed-dose combination 5ARI dutasteride 0.5 mg and α1-adrenoceptor antagonist tamsulosin 0.4 (DUT-TAM FDC) on Men's Sexual Health Questionnaire (MSHQ) domain scores patients lower urinary tract symptoms secondary to benign prostatic hyperplasia (BPH). Methods was post hoc analysis double-blind, randomised, placebo-controlled, parallel-group,...
Objective: To evaluate realworld persistence and adherence in patients with benign prostate hyperplasia (BPH) receiving a fixed-dose combination of dutasteride plus tamsulosin (DUT-TAM FDC) versus α-blocker 5-α reductase inhibitor (AB/5ARI) free-combination therapy.Materials methods: This retrospective, observational cohort study utilized the German IMS LRx (IQVIA) database.Patients ≥ 45 years old BPH DUT-TAM FDC or AB/5ARI therapy from July 1, 2011 to November 30, 2017 were included.Data...
All receptor tyrosine kinases (RTKs) activate similar downstream signaling pathways through a common set of effectors, yet it is not fully understood how different receptors elicit distinct cellular responses to cause cell proliferation, differentiation, or other fates. We tested the hypothesis that regulation SRC family kinase (SFK) by scaffold protein, PAG1, influences fate decisions following RTK activation. generated neuroblastoma line expressing PAG1 fragment lacks membrane-spanning domain (PAG1
To describe the real-world demographic and clinical characteristics of patients with lower urinary tract symptoms (LUTS) as a result benign prostatic hyperplasia (BPH) in Spain.This observational, retrospective, multicentre study conducted primary care urology clinics Spain included men aged ≥50 years diagnosed (≤8 prior to visit) LUTS caused by BPH. The endpoint was characteristics; secondary endpoints disease progression diagnostic tests across both healthcare settings.A total 670 were...
Abstract Background Epanorin (EP) is a secondary metabolite of the Acarospora lichenic species. EP has been found in extracts with antimicrobial activity, and UV-absorption properties have described for closely related molecules; however, its antiproliferative activity cancer cells not yet explored. It hypothesized that inhibits cell growth. MCF-7 breast cells, normal fibroblasts, non-transformed HEK-293 line were exposed to increasing concentrations EP, proliferation was assessed by...
This study aimed to describe the real-world therapeutic management of patients with lower urinary tract symptoms (LUTS) due benign prostatic hyperplasia (BPH) (LUTS/BPH) attending primary care and urology clinics in Spain.This observational, retrospective, multicentre included men ≥50 years age diagnosed LUTS/BPH (≤8 prior visit) (N = 670). Therapeutic according healthcare service (primary vs. clinics) or progression criteria, proportion treatment change, patient profile therapy evolution...
To evaluate the effects of early (≤6 months after starting any medical treatment [baseline] for benign prostatic hyperplasia [BPH]), intermediate (between >6 and 2 years from baseline) late (2 initiation add-on dutasteride therapy on incidence acute urinary retention (AUR) BPH-related surgery in Japanese patients with moderate-to-severe BPH.
To assess the impact of baseline characteristics on Men's Sexual Health Questionnaire (MSHQ) total scores and to evaluate clinical relevance MSHQ changes their association with spontaneously reported sexual adverse events (SexAEs) in patients benign prostatic hyperplasia.This was a post hoc analysis Phase 4 FDC116115 study, which aged ≥50 years were randomised 1:1 receive fixed-dose combination dutasteride 0.5 mg tamsulosin 0.4 (DUT-TAM FDC), or placebo. End-points included: change by...
Abstract All receptor tyrosine kinases (RTKs) activate similar downstream signaling pathways through a common set of effectors, yet it is not fully understood how different receptors elicit distinct cellular responses to cause cell proliferation, differentiation, or other fates. We tested the hypothesis that regulation SRC Family Kinase (SFK) by scaffold protein, PAG1, influences fate decisions following RTK activation. generated neuroblastoma line expressing PAG1 fragment lacks membrane...
Increased cardiac morbidity and mortality are associated with air pollution. Mexico City (MC) residents exposed to high concentrations of fine particulate matter endotoxin. South MC higher endotoxin v North (Rosas 2007). SMC mice had the highest CD14 IL1beta mRNA in myocardium N (Villarreal 2009). To test hypothesis that residency within is a key factor for degree myocardial inflammation, we measured inflammatory mediator genes autopsy samples from R L ventricles 6 15 age‐matched 18.5±5.2y....