A5065595801- Retinal Development and Disorders
- Retinal Diseases and Treatments
- Single-cell and spatial transcriptomics
- CRISPR and Genetic Engineering
Agency for Science, Technology and Research
2022-2023
Institute of Molecular and Cell Biology
2022-2023
Transplantation of stem cell–derived retinal pigment epithelial (RPE) cells is considered a viable therapeutic option for age-related macular degeneration (AMD). Several landmark Phase I/II clinical trials have demonstrated safety and tolerability RPE transplants in AMD patients, albeit with limited efficacy. Currently, there understanding how the recipient retina regulates survival, maturation, fate specification transplanted cells. To address this, we into subretinal space immunocompetent...
Abstract Retinal pigment epithelial (RPE) cell dysfunction and death are characteristics of age-related macular degeneration. A promising therapeutic option is RPE transplantation. Development clinical grade stem-cell derived requires efficient in vitro differentiation purification methods. Enzymatic relies on the relative adherence non-RPE cells to culture plate. However, morphology differ for different stem sources. In cases whereby adhered as strongly plate, enzymatic method unsuitable....