A5064399815- Viral Infectious Diseases and Gene Expression in Insects
- CAR-T cell therapy research
- Synthesis of Organic Compounds
- Multicomponent Synthesis of Heterocycles
- Synthesis and biological activity
- Heavy metals in environment
- 3D Printing in Biomedical Research
- Systemic Sclerosis and Related Diseases
- Geochemistry and Geologic Mapping
- Biomedical and Engineering Education
- Multiple Sclerosis Research Studies
- Virus-based gene therapy research
- Radioactivity and Radon Measurements
University of Mazandaran
2025
Biochemical Society
2019-2020
OptiBiotix (United Kingdom)
2020
University College London
2016-2020
University of Shahrood
2020
Chemistry and Chemical Engineering Research Center of Iran
2018
Abstract: Hematologic malignancies, which arise from dysregulation of hematopoiesis, are a group cancers originating in cells with diminished capacity to differentiate into mature progeny and accumulating immature blood-forming tissues such as lymph nodes bone marrow. Immune- targeted therapies, Immune Checkpoint Blockade (ICB), chimeric antigen receptor T (CAR-T) cell therapy, the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) system, precise, popular, versatile genome...
Abstract Chimeric antigen receptor T‐cell (CAR‐T) therapies have proven clinical efficacy for the treatment of hematological malignancies. However, CAR‐T cell are prohibitively expensive to manufacture. The authors demonstrate manufacture human cells from multiple donors in an automated stirred‐tank bioreactor. successfully produced functional under dynamic conditions a bioreactor, resulting overall yields which were significantly better than static T‐flask culture. At agitation speeds 200...
Abstract Advanced cell and gene therapies such as chimeric antigen receptor T‐cell immunotherapies (CAR‐T), present a novel therapeutic modality for the treatment of acute chronic conditions including lymphoblastic leukemia non‐Hodgkin lymphoma. However, development requires manufacture large numbers T‐cells, which remains major translational commercial bottleneck due to manual, small‐scale, often static culturing systems used their production. Such are because there is an unsubstantiated...
Adoptive T-cell therapy (ACT) has emerged as a promising new way to treat systemic cancers such acute lymphoblastic leukemia. However, the robustness and reproducibility of manufacturing process remains challenge. Here, single-use 24-well microbioreactor (micro-Matrix) was assessed for its use high-throughput screening tool investigate effect interaction different shaking speeds, dissolved oxygen (DO), pH levels on growth differentiation primary T cells in perfusion-mimic process. The full...