A5011046521- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
- CAR-T cell therapy research
- Glioma Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Immune Cell Function and Interaction
- Construction Project Management and Performance
- Immunotherapy and Immune Responses
- Adenosine and Purinergic Signaling
- Risk Management in Financial Firms
- Quality and Supply Management
- Single-cell and spatial transcriptomics
Salk Institute for Biological Studies
2022-2025
The metabolic landscape of cancer greatly influences antitumor immunity, yet it remains unclear how organ-specific metabolites in the tumor microenvironment influence immunosurveillance. We found that accumulation primary conjugated and secondary bile acids (BAs) are features human hepatocellular carcinoma experimental liver models. Inhibiting BA synthesis hepatocytes through deletion BA-conjugating enzyme acid–CoA:amino acid N -acyltransferase (BAAT) enhanced tumor-specific T cell...
Transcription factors (TFs) regulate the differentiation of T cells into diverse states with distinct functionalities. To precisely program desired cell in viral infections and cancers, we generated a comprehensive transcriptional epigenetic atlas nine CD8 + for TF activity prediction. Our analysis catalogued fingerprints each state, uncovering new regulatory mechanisms that govern selective state differentiation. Leveraging this platform, focused on two critical tumor virus control:...
Summary The limited efficacy of immunotherapies against glioblastoma illustrates the urgent need to better understand interactions between central nervous system and immune system. Here, we showed that a protective response αCTLA-4 therapy depended on mutualistic relationship microglia CD4 + T cells. Suppression gliomas by cells did not require tumor-intrinsic MHC-II expression, but rather was dependent selective expression antigen presentation local in turn, sustained cell tumoricidal...