A5020155134- Chronic Lymphocytic Leukemia Research
- Cancer-related Molecular Pathways
- PI3K/AKT/mTOR signaling in cancer
- Ubiquitin and proteasome pathways
- Galectins and Cancer Biology
- Protein Tyrosine Phosphatases
- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- Inflammatory Bowel Disease
- Cellular transport and secretion
- Cancer Cells and Metastasis
- FOXO transcription factor regulation
- Dietary Effects on Health
- MicroRNA in disease regulation
- Protein Kinase Regulation and GTPase Signaling
- RNA modifications and cancer
Universidad de Salamanca
2021-2024
Centro de Investigación del Cáncer
2021-2022
Centro de Investigación Biomédica en Red de Cáncer
2021-2022
Howard Hughes Medical Institute
2018
Broad Institute
2018
Whitehead Institute for Biomedical Research
2018
Koch Institute for Integrative Cancer Research At MIT
2018
Macrophage metalloelastase or matrix metalloproteinase-12 (MMP12) is a macrophage-specific proteolytic enzyme involved in the physiopathology of many inflammatory diseases, including bowel disease. Although previously published data suggested that modulation MMP12 macrophages could be determinant for development intestinal inflammation, scarce information available on mechanisms underlying regulation expression those phagocytes. Therefore, this study, we aimed to delineate association with...
Chronic lymphocytic leukemia (CLL) is the most frequent, and still incurable, form of in Western World. It widely accepted that cancer results from an evolutionary process shaped by acquisition driver mutations which confer selective growth advantage to cells harbor them. Clear examples are missense classic RAS genes (KRAS, HRAS NRAS) underlie development approximately 13% human cancers. Although autonomous B cell antigen receptor (BCR) signaling involved many tumor suppressor oncogenes have...
Biochemical studies of the human ribosome synthesis pathway have been hindered by technical difficulties in obtaining intact preribosomal complexes from internal regions nucleolus. Here we provide a detailed description an extraction method that enables efficient detection, isolation, and characterization nucleolar preribosomes containing large pre-rRNA species. The three-step Preribosome Sequential Extraction (PSE) protocol preserves integrity early yields preparations amenable to...
The R-RAS2 GTP hydrolase (GTPase) (also known as TC21) has been traditionally considered quite similar to classical RAS proteins at the regulatory and signaling levels. Recently, a long-tail hotspot mutation targeting R-RAS2/TC21 Gln72 residue (Q72L) was identified potent oncogenic driver. Additional point mutations were also found in other tumors low frequencies. Despite this, little information is available regarding transforming role of these mutant versions their relevance for...