Renal cell carcinoma (RCC) accounts for 11,000 deaths per year in the United States. When detected early, generally serendipitously by imaging conducted other reasons, long term survival is excellent. with symptoms, prognosis poor. Under these circumstances, a screening biomarker has potential substantial public health benefit. The purpose of this study was to evaluate utility urine metabolomics analysis metabolomic profiling, identification biomarkers, and ultimately devising test RCC....

The metabolic fate and pharmacokinetics of clarithromycin following a single 250- or 1200-mg oral dose 14C-clarithromycin were studied in six healthy adult males. Peak plasma levels averaged 0.6 microgram/ml after the low 2.7 micrograms/ml high dose. AUC increased 13-fold, with 4.8-fold increase dose, while half-life from 4.4 hr to 11.3 hr. major metabolite urine was microbiologically active 14-hydroxylated-R epimer clarithromycin. After 5 days, mean 38% (18% as clarithromycin) 46% (29%...

Polyphenols and fermentable fibers have shown favorable effects on gut microbiota composition metabolic function. However, few studies investigated whether combining multiple or polyphenols may additive beneficial microbial states. Here, an in vitro fermentation model, seeded with human stool combined from 30 healthy volunteers, was supplemented blends of (PP), dietary (FB), their combination (PPFB) to determine influence bacteria growth dynamics select metabolite changes. PP FB...

Polyphenols and fermentable fibers have shown favorable effects on gut microbiota composition metabolic function. However, few studies investigated whether combining multiple or polyphenols may additive beneficial microbial states. Here, an in vitro fer-mentation model, seeded with human stool combined from 30 healthy volunteers, was supplemented blends of (PP), dietary (FB) their combination (PPFB) to determine influence bacteria growth dynamics select metabolite changes. PP FB...

Green tea (GT), cranberry (CR), and tart cherry extracts were evaluated for their ability to inhibit yeast α-glucosidase, relevant glucose uptake. The total phenolic content (TPC), antioxidant activity, in vitro inhibitory activity of α-glucosidase examined the present study. GT had higher TPC but CR demonstrated a greater on basis. was fractionated using LH-20 column chromatography into two fractions: 30% methanol (CME) 70% acetone (CAE). TPC, determined fractions. CAE than CME, fractions...

Probiotics may enhance gastrointestinal health and immune function. The efficacy of different probiotic dosing strategies on colonization persistence probiotics is undefined.The authors assessed Lactobacillus reuteri (L. reuteri) DSM17938 (BioGaia AB, Stockholm, Sweden) after daily or alternate-day dosing.Volunteers ate pudding with L. (10(9) CFU) (n = 9) alternate days over 7 days. Fecal samples were collected (D1-7) ended (D13-15 D20-22) analyzed for the presence reuteri. Results are...

14C-Estazolam (2 mg) administered orally to dogs and human subjects was rapidly completely absorbed with peak plasma levels occurring within one hour. In humans, peaked at 103 +/- 18 ng/ml declined monoexponentially a half-life of 14 h. The mean concn. estazolam in dog 0.5 h 186 ng/ml. Six metabolites were found 8 h, whereas only two detected up Metabolites common both species 1-oxo-estazolam (I) 4-hydroxy-estazolam (IV). Major free conjugated 4-hydroxy-estazolam; the higher dogs. After five...

Abstract Multiyear spaceflight will require innovative strategies to preserve vitamins in foods, order retain astronaut health and functionality long‐term. Furthermore, space foods must be low weight/volume comply with cargo restrictions, sensory quality ensure consumption. Low water activity products were developed, fortified A, B1, B9, C, E at twice their requirements, stored for three years 21 °C one year 38 °C, analyzed annually retained vitamin content organoleptic quality. The...

Purpose: To examine how different proteins in a carbohydrate-protein beverage affect postprandial amino acid (AA), glucose, and insulin responses. Methods: Two randomized, repeated-measures experiments were performed. In one, 10 volunteers drank 3 beverages (380 kcal, 76 g carbohydrate, 19 protein, 2 fat) separate (>7 days) trials, each differing protein type. All drinks consisted of cocoa (4 g) nonfat dry milk (1 supplemented with casein (CAS), whey (WP), or blend (CAS-WP). Ten...

Abstract Development of n‐3 fortified, shelf‐stable foods is facilitated by encapsulated docosahexaenoic acid ( DHA ) and eicosapentaenoic EPA ), since natural food sources cannot withstand high temperature prolonged shelf life. Organoleptic stability has been demonstrated, but chemical changes in the matrix throughout storage could conceivably impact digestibility protein‐based encapsulant thereby compromising bioavailability. We assessed effect high‐temperature variations (proteinaceous or...

Probiotics may enhance gastrointestinal health and immune function. The efficacy of different dosing strategies on colonization persistence probiotics are undefined. We assessed Lactobacillus reuteri ( L. ) (BioGaia, Stockholm, Sweden) after daily or alternate day dosing. Volunteers ate pudding with (10 9 CFU) (DAILY; n = 9) days (ALT; over 7 days. Fecal samples were collected (D1–7) ended (D13–15 D20–22), analyzed for . Results reported in 3‐day increments (D2–4, D5–7, D13–15, D20–22)....

Probiotic-containing foods are consumed to enhance gastrointestinal (GI) and immune function. How storage of those affects persistence probiotics in the GI tract undefined. We evaluated Lactobacillus reuteri DSM17938 (L. reuteri; BioGaia, Stockholm, Sweden) human after consuming “fresh” (FRESH; n = 9; room temperature ≤ 1 week followed by freezer) or “stored” (STORED; 10; 37°C for ~7 days L. reuteri-containing pudding (108 109 CFU/serving, respectively) 7 days. Fecal samples were collected...

Introduction: Plasma amino acid (AA) responses reportedly differ after consuming whey protein (WP) compared to casein (CAS), due difference in digestion. Milk, which contains 80% CAS and 20% WP, produces a seemingly optimal AA response comprised of rapid, postprandial rise attributable WP elevated, sustained concentrations CAS. PURPOSE: To compare effects varying the CAS-WP ratio high-carbohydrate beverage on post-prandial at rest exercise. METHODS: Two randomized, repeated-measures...