A5046358222- Muscle metabolism and nutrition
- High Altitude and Hypoxia
- Adipose Tissue and Metabolism
- Sports Performance and Training
- Diet and metabolism studies
- Cardiovascular and exercise physiology
- Exercise and Physiological Responses
- Pressure Ulcer Prevention and Management
- Wound Healing and Treatments
- Dietary Effects on Health
- Obesity, Physical Activity, Diet
- Genetics and Physical Performance
- Erythropoietin and Anemia Treatment
- Diagnosis and Treatment of Venous Diseases
- MicroRNA in disease regulation
- Iron Metabolism and Disorders
- Nutritional Studies and Diet
- Metabolomics and Mass Spectrometry Studies
- Sleep and related disorders
- Regulation of Appetite and Obesity
- Dietetics, Nutrition, and Education
- Eating Disorders and Behaviors
- Sleep and Work-Related Fatigue
- Sleep and Wakefulness Research
- Dermatology and Skin Diseases
U.S. Army Research Institute of Environmental Medicine
2015-2024
United States Army
2015-2024
Joint Base San Antonio
2023
Oak Ridge Associated Universities
2016
United States Department of the Army
2015
University of St Andrews
2014
Illinois State University
2004-2010
Data from the National Survey of Student Engagement (NSSE) collected across seven years were used to predict final, cumulative grade point averages (GPA). Cross‐product regression was explore predictive abilities NSSE benchmark scores for freshmen (n = 2578) and seniors 2293) in cross‐sectional cohorts. Hierarchical also with 127 longitudinal responses students' first senior college. In analyses, Level Academic Challenge emerged as a significant predictor GPA freshmen, whereas Active...
Strenuous physical activity promotes inflammation and depletes muscle glycogen, which may increase the iron regulatory hormone hepcidin. Hepcidin reduces dietary absorption contribute to declines in status frequently observed following strenuous activity.To determine effects of on hepcidin whether energy deficit compared with balance modifies those effects.This was a randomized, cross-over, controlled-feeding trial healthy male subjects (n = 10, mean ± SD age: 22.4 5.4 y, weight: 87.3 10.9...
Systemic immune function is impaired by sleep restriction. However, the impact of restriction on local responses and to what extent any impairment can be mitigated nutritional supplementation unknown. We assessed effect 72-h (2-h nightly sleep) skin barrier restoration an experimental wound, determined influence habitual protein intake (1.5 g·kg −1 ·day ) supplemented with arginine, glutamine, zinc sulfate, vitamin C, D3, omega-3 fatty acids compared lower (0.8 without supplemental nutrients...
Abstract Sleep restriction alters gut microbiota composition and intestinal barrier function in rodents, but whether similar effects occur humans is unclear. This study aimed to determine the of severe, short-term sleep on permeability healthy adults. Fecal composition, measured by 16S rRNA sequencing, were 19 men (mean ± SD; BMI 24.4 2.3 kg/m 2 , 20 years) undergoing three consecutive nights adequate (AS; 7–9 h sleep/night) restricted (SR; random order with controlled diet physical...
This study investigated how high-altitude (HA, 4300 m) acclimatization affected exogenous glucose oxidation during aerobic exercise. Sea-level (SL) residents (n=14 men) performed 80-min, metabolically-matched exercise (V̇O2 ~ 1.7 L/min) at SL and HA < 5 h after arrival (acute HA, AHA) following 22-d of (chronic CHA). During acclimatization, participants sustained a controlled negative energy balance (-40%) to simulate the "real world" conditions that lowlanders typically experience sojourns....
Background & aimsConsuming 0.10–0.14 g essential amino acids (EAA)/kg/dose (0.25–0.30 protein/kg/dose) maximally stimulates muscle protein synthesis (MPS) during energy balance. Whether consuming EAA beyond that amount enhances MPS and whole-body anabolism following deficit is unknown. The aims of this study were to determine the effects standard high ingestion on mixed turnover deficit.DesignNineteen males (mean ± SD; 23 5 y; 25.4 2.7 kg/m2) completed a randomized, double-blind crossover...
The effects of ingesting varying essential amino acid (EAA)/protein-containing food formats on protein kinetics during energy deficit are undetermined. Therefore, recommendations for EAA/protein necessary to optimize both whole-body balance and muscle synthesis (MPS) unknown. We measured after consuming iso-nitrogenous amounts free-form acid-enriched whey (EAA + W; 34.7 g protein, 24 EAA sourced from EAA), (WHEY; 18.7 or a mixed-macronutrient meal (MEAL; 11.4 EAA) exercise short-term...
This study used global metabolomics to identify metabolic factors that might contribute muscle anabolic resistance, which develops when aerobic exercise is initiated with low glycogen using metabolomics. Eleven men completed this randomized, crossover study, completing two cycle ergometry depletion trials, followed by 24 h of isocaloric refeeding elicit (LOW; 1.5 g/kg carbohydrate, 3.0 fat) or adequate (AD; 6.0 carbohydrate 1.0 glycogen. Participants then performed 80 min cycling (64 ± 3%...
Energy deficiency decreases muscle protein synthesis (MPS), possibly due to greater whole-body essential amino acid (EAA) requirements and reliance on energy stores. Whether deficit-induced anabolic resistance is overcome with non-nitrogenous supplemental or if increased as EAA needed unclear. We tested the effects of carbohydrate, combined an EAA-enriched whey protein, postexercise MPS (%·h -1 ) turnover (g protein·240 min ).
Military personnel frequently endure intermittent periods of severe energy deficit which can compromise health and performance. Physiologic factors contributing to underconsumption, the subsequent drive overeat, are not fully characterized. This study aimed identify associations between appetite, metabolic homeostasis endocrine responses during following severe, short-term deprivation.Twenty-three young adults (17M/6F, 21±3years, BMI 25±3kg/m(2)) participated in a randomized, controlled,...
Sex differences in energy metabolism during acute, submaximal exercise are well documented. Whether these sex influence metabolic and physiological responses to sustained, physically demanding activities is not characterized. This study aimed identify within changes the serum metabolome relation body composition, physical performance, circulating markers of endocrine status a 17-day military training exercise. Blood was collected, composition lower power were measured before after on 72...
Abstract This study investigated the effects of EPO on hemoglobin (Hgb) and hematocrit (Hct), time trial (TT) performance, substrate oxidation, skeletal muscle phenotype throughout 28 days strenuous exercise. Eight males completed this longitudinal controlled exercise feeding using (50 IU/kg body mass) 3×/week for days. Hgb, Hct, TT performance were assessed PRE Days 7, 14, 21, 27 EPO. Rested/fasted obtained POST analyzed gene expression, protein signaling, fiber type, capillarization....
Consumption of certain berries appears to slow postprandial glucose absorption, attributable polyphenols, which may benefit exercise and cognition, reduce appetite and/or oxidative stress. This randomised, crossover, placebo-controlled study determined whether polyphenol-rich fruits added carbohydrate-based foods produce a dose-dependent moderation glycaemic, glucoregulatory hormone, ex vivo stress responses. Twenty participants (eighteen males/two females; 24 (sd 5) years; BMI: 27 3) kg/m2)...
Military personnel and some athlete populations endure short-term energy deficits from reduced intake and/or increased expenditure (EE) that may degrade physical cognitive performance due to severe hypoglycemia (<3.1 mmol/l). The extent which alter normoglycemia (3.9–7.8 mmol/l) in healthy individuals is not known, since prior studies measured glucose infrequently, continuously. purpose of this study was characterize the glycemic response acute, deficit compared with fully fed control...
Hypoxia-induced insulin resistance appears to suppress exogenous glucose oxidation during metabolically matched aerobic exercise acute (<8 h) high-altitude (HA) exposure. However, a better understanding of this metabolic dysregulation is needed identify interventions mitigate these effects. The objective study was determine if differences in metabolomic profiles at sea level (SL) and HA are reflective hypoxia-induced resistance. Native lowlanders ( n = 8 males) consumed 145 g (1.8 g/min)...