A5046461621- Exercise and Physiological Responses
- Muscle metabolism and nutrition
- Cardiovascular and exercise physiology
- Adipose Tissue and Metabolism
- Osteoarthritis Treatment and Mechanisms
- Erythropoietin and Anemia Treatment
- Sports Performance and Training
- Total Knee Arthroplasty Outcomes
- Physical Activity and Health
- Genetics and Physical Performance
- Knee injuries and reconstruction techniques
- High Altitude and Hypoxia
- Muscle Physiology and Disorders
- MicroRNA in disease regulation
- Cardiovascular Effects of Exercise
- Iron Metabolism and Disorders
- Behavioral Health and Interventions
- Animal testing and alternatives
- Stroke Rehabilitation and Recovery
- Thermoregulation and physiological responses
- Psychological Well-being and Life Satisfaction
- Motivation and Self-Concept in Sports
- Cancer, Hypoxia, and Metabolism
- Physical Education and Training Studies
- Rheumatoid Arthritis Research and Therapies
University of Alabama at Birmingham
2020-2025
Oak Ridge Associated Universities
2024-2025
U.S. Army Research Institute of Environmental Medicine
2023-2025
United States Army
2023-2025
Oak Ridge Institute for Science and Education
2024-2025
Florida Institute for Human and Machine Cognition
2024
Central Washington University
2017-2022
University of Idaho
2015-2017
High-intensity interval training (HIIT) has been shown to improve cardiometabolic health during supervised lab-based studies but adherence, enjoyment, and benefits of HIIT performed independently are yet be understood. We compared outcomes after 8 weeks or moderate-intensity continuous (MICT), matched for energy expenditure, in overweight obese young adults.
In a randomized, dose-response trial, we used molecular and phenomic profiling to compare responses traditional (TRAD) endurance plus resistance training high-intensity tactical (HITT). Ninety-four participants (18-27 years) completed 12 weeks of TRAD or HITT followed by 4 detraining. While in vivo phenotype improvements were not dose-dependent, few dose-dependent ex muscle adaptations overshadowed wide-ranging inter-individual response heterogeneity (IRH). To address this, established...
For centuries, regular exercise has been acknowledged as a potent stimulus to promote, maintain, and restore healthy functioning of nearly every physiological system the human body. With advancing understanding complexity physiology, continually evolving methodological possibilities, an increasingly dire public health situation, study preventative or therapeutic treatment never more interdisciplinary, impactful. During early stages NIH Common Fund Molecular Transducers Physical Activity...
Using a within-subject unilateral design, we demonstrated that increasing resistance training (RT) volume may be simple, effective strategy to improve muscle hypertrophy and strength gains among older adults who do not respond low-volume RT. In addition, it could most likely used further hypertrophic outcomes in responders.
We examined small and long transcriptomics in skeletal muscle serum-derived extracellular vesicles before after a single exposure to traditional combined exercise (TRAD) high-intensity tactical training (HITT). Across 40 young adults, we found more consistent protein-coding gene responses TRAD, whereas HITT elicited differential expression of microRNA enriched brain regions. Follow-up analysis revealed relationships temporal dynamics across transcript networks, highlighting potential avenues...
The majority of exercise physiology research has been conducted in males, resulting a skewed biological representation how impacts the physiological system. Extrapolating male-centric findings to females is not universally appropriate and may even be detrimental. Thus, addressing this imbalance taking into consideration sex as variable mandatory for optimization precision interventions and/or regimens. Our present analysis focused on establishing multiomic profiles young, exercise-naïve...
Exogenous glucose oxidation is reduced 55% during aerobic exercise after three days of complete starvation. Whether energy deficits more commonly experienced by athletes and military personnel similarly affect exogenous what impact this has on physical performance remains undetermined. This randomized, longitudinal parallel study aimed to assess the effects varying magnitudes deficit (DEF) glucoseoxidation compared balance (BAL). Participants consumed a4-day BAL diet, followed a 6-day 20% (...
Many individuals with end-stage osteoarthritis (OA) undergo elective total hip/knee arthroplasty (THA/TKA) to relieve pain, improve mobility and quality of life. However, ∼30% suffer long-term impairment following surgery. This may be in part due muscle inflammation susceptibility (MuIS+), an overt proinflammatory pathology localized skeletal surrounding the diseased joint, present some patients TKA/THA. We interrogated hypothesis that MuIS+ status results a perturbed perioperative gene...
Abstract This study investigated the effects of EPO on hemoglobin (Hgb) and hematocrit (Hct), time trial (TT) performance, substrate oxidation, skeletal muscle phenotype throughout 28 days strenuous exercise. Eight males completed this longitudinal controlled exercise feeding using (50 IU/kg body mass) 3×/week for days. Hgb, Hct, TT performance were assessed PRE Days 7, 14, 21, 27 EPO. Rested/fasted obtained POST analyzed gene expression, protein signaling, fiber type, capillarization....
Resistance training (RT) remains the most effective treatment for age-related declines in muscle mass. However, many older adults experience attenuated hypertrophy response to RT when compared with younger adults. This may be attributed underlying molecular processes that are dysregulated by aging and exacerbated improperly prescribed weekly volume, intensity, and/or frequency doses. MicroRNAs (miRNAs) key epigenetic regulators impact signaling pathways protein expression within cells,...
The ability of individuals with end-stage osteoarthritis (OA) to functionally recover from total joint arthroplasty is highly inconsistent. molecular mechanisms driving this heterogeneity have yet be elucidated. Furthermore, OA disproportionately impacts females, suggesting a need for identifying female-specific therapeutic targets. We profiled the skeletal muscle transcriptome in females (n = 20) undergoing knee or hip using RNA-Seq. Single-gene differential expression (DE) analyses tested...
Insulin insensitivity decreases exogenous glucose oxidation and metabolic clearance rate (MCR) during aerobic exercise in unacclimatized lowlanders at high altitude (HA). Whether use of an oral insulin sensitizer before acute HA exposure enhances is unclear. This study investigated the impact pioglitazone (PIO) on turnover compared with placebo (PLA) HA. With a randomized crossover design, native (
Low carbohydrate availability during recovery from aerobic exercise alters skeletal muscle microRNA (miRNA) profiles, which may mechanistically regulate recovery. However, its impact on circulating miRNA (c-miRNA) profiles remains unclear.
Background: Hypoxia-induced insulin insensitivity decreases exogenous glucose oxidation and metabolic clearance rate (MCR, proxy for peripheral uptake) in native lowlanders exercising during the initial hours of high-altitude (HA) exposure compared sea level. These data suggest that administering an sensitizing drug before HA may increase by stimulating uptake. Objective: To compare effects pioglitazone (PIO) placebo (PLA) on MCR steady-state aerobic exercise at HA. We hypothesized would be...
Strenuous physical training increases total blood volume (BV) through expansion of plasma (PV) and red cell volumes (RCV). In contrast, exogenous erythropoietin (EPO) treatment RCV but decreases PV, rendering BV stable or slightly decreased. This study aimed to determine the combined effects strenuous EPO on markers systemic muscle iron homeostasis. this longitudinal study, 8 healthy non-anemic males were treated with (50 IU/kg body mass, 3x/week, subcutaneously) across 28 days (4d/week,...
Long INterspersed Element-1 (L1) is an autonomous transposable element in the genome. L1 transcripts that are not reverse transcribed back into genome can accumulate cytoplasm and activate inflammatory response via cyclic GMP-AMP (cGAS)-STING pathway. We examined skeletal muscle markers as well STING protein levels 10 older individuals (63 ± 11 y, BMI = 30.2 6.8 kg/m2) with end-stage osteoarthritis (OA) undergoing total hip (THA, n 4) or knee (TKA, 6) arthroplasty versus young, healthy...
Montmorency Cherry Juice (MCJ) may improve acute exercise recovery by attenuating inflammation and oxidative stress. However, the anti-inflammatory effects of MCJ on monocyte responses following resistance have not been explored. Seven resistance-trained males (age: 22.9 ± 4.1 yrs; height: 1.8 0.1 m; weight: 81.7 13.2 kg) participated in this study. Participants completed a placebo-controlled crossover design, drinking either or placebo beverages, 7 days prior to completing an bout...