A5017118783- Intensive Care Unit Cognitive Disorders
- Sepsis Diagnosis and Treatment
- Nutrition and Health in Aging
- Respiratory Support and Mechanisms
- Heart Rate Variability and Autonomic Control
- Physical Activity and Health
- Gut microbiota and health
- Adipose Tissue and Metabolism
- Cardiovascular and exercise physiology
- Frailty in Older Adults
- Congenital Diaphragmatic Hernia Studies
- Long-Term Effects of COVID-19
- Clostridium difficile and Clostridium perfringens research
- Muscle Physiology and Disorders
- Sirtuins and Resveratrol in Medicine
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Trace Elements in Health
- Dietary Effects on Health
- Iron Metabolism and Disorders
- Vitamin C and Antioxidants Research
- Mitochondrial Function and Pathology
- Hemoglobinopathies and Related Disorders
- Technology Use by Older Adults
- Genetics and Physical Performance
- High Altitude and Hypoxia
University of Florida
2016-2025
University of Alabama at Birmingham
2019-2025
Florida College
2020-2024
University of Alabama
2024
Gainesville Obstetrics & Gynecology
2022-2023
Maine Farmland Trust
2022
Wake Forest University
2022
Tallahassee Orthopedic Clinic
2022
Institute on Aging
2015-2021
Bentley Systems (United Kingdom)
2020
Iron plays a crucial role in many physiological processes, including oxygen transport, bioenergetics, and immune function. is assimilated from food also recycled senescent red blood cells. exists two dietary forms: heme (animal based) non-heme (mostly plant based). The body uses iron for metabolic purposes, stores the excess mainly splenic hepatic macrophages. Physiologically, excretion humans inefficient not highly regulated, so regulation of intestinal absorption maintains homeostasis....
This study sought to examine mortality, health-related quality of life, and physical function among sepsis survivors who developed chronic critical illness.Single-institution, prospective, longitudinal, observational cohort assessing 12-month outcomes.Two surgical/trauma ICUs at an academic tertiary medical level 1 trauma center.Adult critically ill patients that survived 14 days or longer after onset.None.Baseline patient characteristics function, severity, clinical outcomes the index...
Abstract Background Sepsis and trauma are known to disrupt gut bacterial microbiome communities, but the impacts perturbations in fungal (mycobiome) community after severe infection or injury, particularly patients experiencing chronic critical illness (CCI), remain unstudied. Methods We assess persistence of mycobiome perturbation (dysbiosis) CCI following sepsis for up two-to-three weeks intensive care unit hospitalization. Results show that dysbiotic arrays shift toward a pathobiome...
Objectives Sepsis has been called a “disease of the elderly,” and as in‐hospital mortality decreased, more sepsis survivors are progressing into poorly characterized long‐term outcomes. The purpose this study was to describe current epidemiology in older adults compared with middle‐aged young adults. Design Prospective longitudinal (≤45 years), (46‐64 (≥65 years) patient groups. Setting University tertiary medical center. Participants A total 328 adult surgical intensive care unit (ICU)...
In Brief Export A review of UF SCIRC's research efforts characterizing CCI, PICS biomarkers, effect site infection, acute kidney injury, effects on older patients, dysfunctional high-density lipoproteins, sarcopenia/cachexia, emergency myelopoiesis, and dysregulated erythropoiesis.
Objective: The purpose of this trial was to study the effects chronic resveratrol use on cognitive function in humans. Design: authors conducted a double-blind, Phase IIa randomized, placebo-controlled obtain preliminary estimates supplementation over 90-day period older adults. Location: University Florida Gainesville, FL. Subjects: Sedentary, overweight adults (N = 32; age range: 65–93 years, M 73.34 SD 7.02 years). Intervention: Participants were randomized one three treatment groups...
Exercise is widely recognized as a critical component of healthy lifestyle by multiple scientific and regulatory bodies. Yet only 35% adults in the United States even report engaging regular physical activity. In response to this challenge, Medicine (EIM) initiative encourages clinicians all settings regularly assess counsel patients on activity an attempt reduce levels inactivity. The purpose article highlight key challenges implementation EIM promote identify potential opportunities...
Whether disruption of iron metabolism is implicated in human muscle aging presently unclear. We explored the relationship among metabolism, mitochondrial homeostasis, inflammation, and physical function older adults young controls. Eleven 23 men women were included. Older classified into high–functioning (HF) low–functioning (LF) groups according to their Short Physical Performance Battery score. Vastus lateralis biopsies assayed for total content, expression 8-oxoguanine DNA glycosylase...
Altered mitochondrial quality and function in muscle may be involved age-related physical decline. The role played by the autophagy–lysosome system, a major component of control (MQC), is incompletely understood. This study was undertaken to obtain initial indications on relationship between autophagy, mitophagy, lysosomal markers measures performance lower extremity tissue composition young older adults. Twenty-three participants were enrolled, nine (mean age: 24.3 ± 4.3 years) 14 adults...
Abstract Background Hospital deaths after sepsis have decreased substantially and most young adult survivors rapidly recover (RAP). However, many older develop chronic critical illness (CCI) with poor long-term outcomes. The etiology of CCI is multifactorial the relative importance remains unclear. Sepsis caused by a dysregulated immune response biomarkers reflecting persistent inflammation, immunosuppression, catabolism syndrome (PICS) been observed in sepsis. Therefore, purpose this study...
Mechanical ventilation (MV) during a cardio-thoracic surgery contributes to diaphragm muscle dysfunction that impairs weaning and can lead the ventilator- induced dysfunction. Especially, it is critical in older adults who have lower reparative capacity following MV. Reports shown intraoperative intermittent hemidiaphragm electrical stimulation maintain and/or improve post-surgery function. In particular, from molecular point of view, ES may reduce oxidative stress increase regulatory...
Objectives To examine associations between objectively measured physical activity ( PA ) and incidence of major mobility disability MMD persistent PMMD in older adults the Lifestyle Interventions Independence for Elders LIFE Study. Design Prospective cohort individuals aged 65 undergoing structured intervention or health education. Setting The Study was a multicenter (eight sites) randomized controlled trial designed to compare efficacy long‐term with that education (HE) program reducing...