A5061204715- Muscle Physiology and Disorders
- Exercise and Physiological Responses
- Adipose Tissue and Metabolism
- Muscle metabolism and nutrition
- Cardiovascular and exercise physiology
- Nutrition and Health in Aging
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Genetics and Physical Performance
- Neurogenetic and Muscular Disorders Research
- Osteoarthritis Treatment and Mechanisms
- Sports Performance and Training
- Cardiovascular Effects of Exercise
- Pharmacological Effects and Assays
- Knee injuries and reconstruction techniques
- Total Knee Arthroplasty Outcomes
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Parkinson's Disease Mechanisms and Treatments
- Extracellular vesicles in disease
- Signaling Pathways in Disease
- Health Sciences Research and Education
- Inflammatory mediators and NSAID effects
- Sports injuries and prevention
- Spaceflight effects on biology
- Mosquito-borne diseases and control
- Behavioral Health and Interventions
University of Alabama at Birmingham
2018-2025
Florida Institute for Human and Machine Cognition
2021-2025
Ball State University
2013-2024
Pulmonary and Allergy Associates
2024
Georgetown University
2011-2012
Marywood University
2012
Duke Medical Center
2006
Age-associated chronic basal inflammation compromises muscle mass and adaptability, but exercise training may exert an anti-inflammatory effect. This investigation assessed exercise-induced in three cohorts of men: young exercisers [YE; n = 10 men; 25 ± 1 yr; maximal oxygen consumption (V̇o 2max ), 53 3 mL·kg −1 ·min ; quadriceps area, 78 cm 2 means SE], old healthy nonexercisers (OH; 10; 75 V̇o , 22 56 lifelong with aerobic history yr (LLE; 21; 74 34 67 ). Resting serum IL-6, TNF-α,...
The purpose of this study was to examine the effects aerobic lifelong exercise (LLE) on maximum oxygen consumption (V̇o2max) and skeletal muscle metabolic fitness in trained women ( n = 7, 72 ± 2 yr) men 21, 74 1 compare them old, healthy nonexercisers (OH; women: 10, 75 yr; men: young exercisers (YE; 25 yr). LLE were further subdivided based intensity competitive status into performance (LLE-P, 14) (LLE-F, 7). On average, exercised 5 day/wk for 7 h/wk over past 52 yr. Each subject performed...
For centuries, regular exercise has been acknowledged as a potent stimulus to promote, maintain, and restore healthy functioning of nearly every physiological system the human body. With advancing understanding complexity physiology, continually evolving methodological possibilities, an increasingly dire public health situation, study preventative or therapeutic treatment never more interdisciplinary, impactful. During early stages NIH Common Fund Molecular Transducers Physical Activity...
Using a within-subject unilateral design, we demonstrated that increasing resistance training (RT) volume may be simple, effective strategy to improve muscle hypertrophy and strength gains among older adults who do not respond low-volume RT. In addition, it could most likely used further hypertrophic outcomes in responders.
We examined small and long transcriptomics in skeletal muscle serum-derived extracellular vesicles before after a single exposure to traditional combined exercise (TRAD) high-intensity tactical training (HITT). Across 40 young adults, we found more consistent protein-coding gene responses TRAD, whereas HITT elicited differential expression of microRNA enriched brain regions. Follow-up analysis revealed relationships temporal dynamics across transcript networks, highlighting potential avenues...
The most widely validated animal models of the positive, negative and cognitive symptoms schizophrenia involve administration d-amphetamine or open channel NMDA receptor blockers, dizocilpine (MK-801), phencyclidine (PCP) ketamine. drug ZJ43 potently inhibits glutamate carboxypeptidase II (GCPII), an enzyme that inactivates peptide transmitter N-acetylaspartylglutamate (NAAG) reduces positive behaviors induced by PCP in several these models. NAAG is agonist at metabotropic 3 (mGluR3)....
Common cyclooxygenase (COX)-inhibiting drugs enhance resistance exercise induced muscle mass and strength gains in older individuals. The purpose of this investigation was to determine whether the underlying mechanism regulating effect specific Type I or II fibers, which have different contractile metabolic profiles. Muscle biopsies (vastus lateralis) were obtained before after 12 weeks knee-extensor (3 days/week) from healthy men who consumed either a placebo ( n = 8; 64±2 years) COX...
Ageing of skeletal muscle is characterized in some by fiber type grouping due to denervation-reinnervation cycles, but the severity varies widely across individuals same chronological age. It remains unknown whether associated with lower mass and/or reduced physical function elderly. Therefore, we assessed relationship between and indices older adults. In addition, affected prolonged resistance training Twenty young (21 ± 2 y) twenty (70 4 healthy men participated present study. Body...
Spinal cord injury (SCI) results in rapid muscle loss. Exogenous molecular interventions to slow atrophy after SCI have been relatively ineffective and require the search for novel therapeutic targets. Connexin hemichannels (CxHCs) allow nonselective passage of small molecules into out cell. Boldine, a CxHC-inhibiting aporphine found boldo tree (
The efficacy of the NASA SPRINT exercise countermeasures program for quadriceps (vastus lateralis) and triceps surae (soleus) skeletal muscle health was investigated during 70 days simulated microgravity. Individuals completed 6° head-down-tilt bedrest (BR,
We previously reported a positive effect of lifelong exercise on skeletal muscle inflammation in aging men. This parallel investigation women revealed that did not protect against age-related increases circulating or and preparedness to handle loading stress was preserved by exercise. Further is necessary understand why aerobic may confer the same anti-inflammatory benefits as it does
Exercising regularly promotes health, but these benefits are complicated by acute inflammation induced exercise. A potential source of is cell-free DNA (cfDNA), yet the cellular origins, molecular causes, and immune system interactions exercise-induced cfDNA unclear. To study these, 10 healthy individuals were randomized to a 12-wk exercise program either high-intensity tactical training (HITT) or traditional moderate-intensity (TRAD). Blood plasma was collected pre- postexercise at weeks 0...
In a randomized, dose-response trial, we used molecular and phenomic profiling to compare responses traditional (TRAD) endurance plus resistance training high-intensity tactical (HITT). Ninety-four participants (18-27 years) completed 12 weeks of TRAD or HITT followed by 4 detraining. While in vivo phenotype improvements were not dose-dependent, few dose-dependent ex muscle adaptations overshadowed wide-ranging inter-individual response heterogeneity (IRH). To address this, established...
The majority of exercise physiology research has been conducted in males, resulting a skewed biological representation how impacts the physiological system. Extrapolating male-centric findings to females is not universally appropriate and may even be detrimental. Thus, addressing this imbalance taking into consideration sex as variable mandatory for optimization precision interventions and/or regimens. Our present analysis focused on establishing multiomic profiles young, exercise-naïve...
Low-carbohydrate, high-fat diets enhance lipid metabolism and decrease reliance on glucose oxidation in athletes, but the associated gene expression patterns remain unclear. The purpose of this study was to determine whether coordinated molecular pathways skeletal muscle may be revealed by differential genes driven dietary profile, exercise, and/or their interaction. We investigated transcriptome elite ultra-endurance athletes habitually (~ 20 months) consuming a high-carbohydrate, low-fat...
Exercise and diet are direct physical contributors to human health, wellness, resilience, performance [1-5]. Endurance resistance training known improve healthspan through various biological processes such as mitochondrial function [6-8], telomere maintenance [9], inflammaging [10]. Although several prescriptions have been defined with specific merits [1,10-20], the long-term effects of these in terms their molecular alterations not yet well explored. In this study, we focus on two combined...
Respiratory muscle fatigue can negatively impact athletic performance, but swimming has beneficial effects on the respiratory system and may reduce susceptibility to fatigue. Limiting breath frequency during further stresses through hypercapnia mechanical loading lead appreciable improvements in strength. This study assessed of controlled‐frequency ( CFB ) pulmonary function. Eighteen subjects (10 men), average (standard deviation) age 25 (6) years, body mass index 24.4 (3.7) kg/m 2 ,...
Prostaglandin E2 (PGE2) produced by the cyclooxygenase (COX) pathway regulates skeletal muscle protein turnover and exercise training adaptations. The purpose of this study was twofold: 1) define PGE2/COX enzymes receptors in human muscle, with a focus on type I II fibers; 2) examine influence aging pathway. Muscle biopsies were obtained from soleus (primarily fibers) vastus lateralis (proportionally more fibers than soleus) young men women (n = 8; 26 ± 2 yr), 25 1 yr) old 12; 79 women....