The formulation and implementation of national ethical regulations to protect research participants is fundamental conduct research. Ethics education capacity are inadequate in developing African countries. This study was designed develop a module for online training ethics based on the Nigerian National Code Health Research assess its ease use reliability among biomedical researchers Nigeria.This three-phased evaluation study. Phase one involved development an (NCHRE) uploading it...

Background : Depression has significant negative impact on the quality of life in patients with epilepsy (PWE). Aim: This study assessed prevalence depression PWE and seizure variables scores. Settings Design A case-control randomly selected attending a tertiary hospital metropolitan, Nigeria. Materials Methods total 152 subjects Beck Inventory (BDI) for quantitative assessment depression, while Hamilton Rating Scale (HRSD) was used by investigators. Statistical Analysis The Student t test...

Stroke is one of the major challenges facing medicine with a frightening statistics being second leading cause death and physical disability worldwide. Identification management risk factors remains key to reducing morbidity mortality from stroke. Eighty patients clinical presentation stroke were recruited consecutively Emergency Departments University Teaching Hospital Specialist - both situated in Benin City, Nigeria. The followed up for two year period (June 2000 June 2002) analysis was...

Memory impairment, usually impaired retrieval of information, has been described in HIV/AIDS, especially among those with severe illness. Neuro-cognitive disturbances HIV/AIDS have linked to poor quality life and medication adherence. This prospective, case-control study was designed assess the verbal non-verbal memory as well attention abilities Nigerian Africans correlate their performances CD4+ T lymphocytes (CD4+) counts.A total 288 randomly selected subjects, comprising 96 HIV-positive...

Objective As genomic research gathers momentum in sub-Saharan Africa, it has become increasingly important to understand the reasons why individuals wish participate this kind of medical research. Against background communitarianism conceived as typical African communities, is often suggested that consent on grounds solidarity and further common good. In paper, we seek explore contention by presenting data from focus groups with potential participants about what would influence their...

Chronic kidney disease (CKD) has become a public health concern and may be complicated by cognitive impairment (CI) contributing significantly to morbidity poor prognosis. This hospital-based study aimed at determining the prevalence determinants of CI among CKD patients in Nigeria.A total 190 100 healthy control subjects completed this cross-sectional study. Sociodemographic data history common clinical features were obtained with use interviewer administered semi-structured questionnaires....

There is a complex inter-relationship between sleep disorders and epilepsy, there are few studies in Nigeria on epilepsy. This study was carried out to determine the prevalence, pattern predictors of disturbances among persons with epilepsy (PWE).This multi-center, cross-sectional 124 PWE Nigeria. A questionnaire used collect data social demographic variables, epilepsy- related variables PWE. Exclusion criteria were mental retardation, use sedative drugs. The analyzed using Statistical...

Epilepsy is the most common non-infectious neurologic disease in developing countries such as Africa, including Nigeria. This study was designed to assess intellectual performance of patients with epilepsy (PWE) Nigeria hoping that result will serve basis for educational, vocational, and social counseling.Forty-one PWE were studied along 41 age-, sex- education-matched healthy controls. A questionnaire developed applied all subjects history taken from eyewitness. The function each subject...

There are conflicting reports on the presence of neurocognitive dysfunction during initial, medically asymptomatic stage HIV infection. This study aimed to assess psychomotor speed and attention ability antiretroviral treatment-naïve Nigerian Africans with HIV/AIDS impact CD4 levels their cognitive performance. Two hundred eighty-eight randomly selected age-, sex- level education-matched subjects participated, comprising 96 HIV-positive symptomatic patients HIV-negative controls. The simple...

Background / Objective : The morbidity and mortality of neurological patients managed in the intensive care unit reflect causes disorders effectiveness management.Method patterns admitted into University Benin Teaching Hospital (UBTH), a tertiary health institution Nigeria, was examined over an 18-year period (January 1985 to December 2003). A complete sampling frame used with all patients' records scrutinized.Results total 187 patients, (16.6% ICU admissions) were during period. We observed...

Objective The identification of risk factors that predispose to development epilepsy is crucial its primary prevention. This study evaluated the risks conferred by some predisposing factors. Patients and methods cross-sectional analytical assessed relative contributions various in 244 adult Nigerians with compared equal number age- sex-matched controls. Odds ratio Fisher exact test were used express significant association. Results Birth asphyxia (OR 6.87), recurrent childhood febrile...

The objective of this study was to evaluate the pattern cognitive disturbances in Nigerian Africans with newly diagnosed epilepsy, prior onset drug therapy.A total 60 consecutive patients (mean age 31.6 +/- 17.4, range 14-55 years) presenting a clinical diagnosis epilepsy were recruited for study. Sixty healthy volunteers without history and who age-, sex- level education matched epileptic patients, as controls. administration tests done FePsy computerized neuropsychological test battery....

Purpose The purpose of this paper is to examine perceptions need dissatisfaction and importance in the two groups orthodox medical doctors Nigeria, relating these motivational variables quality in‐patient care. Design/methodology/approach draws on Maslow's theory, question format Heller Porter's study; 33 government‐employed doctors, 29 private practitioners were surveyed. “ t ‐test” Mann‐Whitney test employed statistical analysis. Findings finds that differed significantly with respect 13...

Responsibility for protection of research participants from harm and exploitation rests on Research Ethics Committees principal investigators. The Nigerian National Code Health defines responsibilities stakeholders in so its knowledge among researchers will likely aid ethical conduct research. levels awareness the biomedical southern institutions was assessed. Four were selected using a stratified random sampling technique. by purposive completed pre-tested structured questionnaire. A total...

Objective:The knowledge and application of ethical principles to the conduct human subjects' research is crucial integrity industry.This study sought assess practice ethics among biomedical researchers in institutions southern Nigeria.Methods: Four tertiary from three geo-political zones situated part Nigeria were selected using a stratified random sampling technique.Research participants then by purposive these institutions.The assessed with pre-tested structured questionnaire.Statistical...

This is an analysis of the effects prognosticating factors on outcome a case series 66 patients with tetanus, presenting between 1990 and 2000. The mortality rate was 26.2% fatality 16.2% for those under 40 years age. increased to 75% above 70 socioeconomic status, immunization incubation period, age patient together severity spasms, duration hospital stay, type treatment received time onset were found affect patients.

Post traumatic epilepsy is recurrent chronic seizures occurring after four weeks following brain injury. It commonly occurs road traffic accidents thus making it a preventable cause of seizures. The prevalence and pattern this disorder not known among Nigerian patients with epilepsy.This study aimed at determining the predisposing type head injury to developing post epilepsy.We studied 244 consecutive attending neurology clinic tertiary health facility in an urban city by analyzing details...

Achieving the objectives of rolling out genomic research programs in sub-Saharan Africa depends on how prepared indigenous biomedical researchers are for this type research. We explored level preparedness a African country using in-depth interviews to obtain data their understanding genomics and assess awareness scope country's code health ethics. Thirty were interviewed. Only eight familiar with concepts genomics, form "genomic literacy." The majority not aware This study showed that...