A5040990016- RNA and protein synthesis mechanisms
- RNA Interference and Gene Delivery
- RNA Research and Splicing
- Advanced biosensing and bioanalysis techniques
- RNA modifications and cancer
- Glycosylation and Glycoproteins Research
- Biotin and Related Studies
- Click Chemistry and Applications
- Microtubule and mitosis dynamics
- Proteoglycans and glycosaminoglycans research
Boston Children's Hospital
2023-2025
Harvard University
2024
Abstract Receptor-ligand interactions govern a wide array of biological pathways, facilitating cell’s ability to interrogate and integrate information from the extracellular space. Here, using an unbiased genome-wide knockout screen, we identify heparan sulfate proteoglycans (HSPGs) as major component in organizational mechanism cell surface glycoRNA RNA binding proteins (csRBPs). Cleavage mature chains, N- 6- O -sulfotransferases, overexpression endo-6- -sulfatases, or addition exogenous...
Abstract The composition and organization of the cell surface determine how cells interact with their environment. Traditionally, glycosylated transmembrane proteins were thought to be major constituents external plasma membrane. Here, we provide evidence that a group RNA binding (RBPs) are present on living cells. These RBPs (csRBPs) precisely organize into well-defined nanoclusters enriched for multiple RBPs, glycoRNAs, clustering can disrupted by extracellular RNase addition....
In an interview with Dr. Mishtu Dey, editor-in-chief of <i>Cell Chemical Biology</i>, the authors review titled "Tools to investigate cell surface: Proximity as a central concept in glycoRNA biology"—Lauren Kageler, Jonathan Perr, and Ryan A. Flynn—tell us more about their career paths what excites them science.