A5028813046- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Luminescence and Fluorescent Materials
- Advanced Fluorescence Microscopy Techniques
- RNA and protein synthesis mechanisms
- Porphyrin and Phthalocyanine Chemistry
- Nanoplatforms for cancer theranostics
- RNA Research and Splicing
- Ubiquitin and proteasome pathways
- Cancer Research and Treatments
- Advanced Biosensing Techniques and Applications
- Glycosylation and Glycoproteins Research
- Studies on Chitinases and Chitosanases
- Near-Field Optical Microscopy
- Advanced Electron Microscopy Techniques and Applications
- Protein Hydrolysis and Bioactive Peptides
- Photoreceptor and optogenetics research
- Carbohydrate Chemistry and Synthesis
- Photochromic and Fluorescence Chemistry
Max Planck Institute for the Science of Light
2022-2025
ETH Zurich
2024
Glycans are one of the fundamental biopolymers encountered in living systems. Compared to polynucleotide and polypeptide biosynthesis, polysaccharide biosynthesis is a uniquely combinatorial process which interdependent enzymes with seemingly broad specificities contribute. The resulting intracellular cell surface, secreted glycans play key roles health disease, from embryogenesis cancer progression. study modulation organismal biology aided by small molecule inhibitors involved glycan...
Abstract The composition and organization of the cell surface determine how cells interact with their environment. Traditionally, glycosylated transmembrane proteins were thought to be major constituents external plasma membrane. Here, we provide evidence that a group RNA binding (RBPs) are present on living cells. These RBPs (csRBPs) precisely organize into well-defined nanoclusters enriched for multiple RBPs, glycoRNAs, clustering can disrupted by extracellular RNase addition....
Precise cell elimination within intricate cellular populations is hampered by issues arising from the multifaceted biological properties of cells and expansive reactivity chemical agents. Current platforms are often limited their complexity, toxicity, poor physical/chemical properties. Here, we report on synthesis a structurally versatile library chemically tunable bisacylphosphane oxides (BAPOs), which harnesses spatiotemporal precision light delivery, thereby establishing universal...
Research during the past 2 decades has showcased power of single-molecule localization microscopy (SMLM) as a tool for exploring nanoworld. However, SMLM systems are typically available in specialized laboratories and imaging facilities, owing to their expensiveness well complex assembly alignment procedure. Here, we lay out blueprint sturdy, rail-based, cost-efficient, multicolor setup that is easy construct align service simplifying accessibility SMLM. We characterize optical properties...
Abstract Precise cell elimination within intricate cellular populations is hampered by issues arising from the multifaceted biological properties of cells and expansive reactivity chemical agents. Current platforms are often limited their complexity, toxicity, poor physical/chemical properties. Here, we integrate spatio-temporal precision light delivery structural versatility bisacylphosphane oxides (BAPOs), establishing a universal strategy for on-demand, precise ablation in vitro vivo .