A5069108806- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- RNA Research and Splicing
- Mycobacterium research and diagnosis
- melanin and skin pigmentation
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Biochemical Analysis and Sensing Techniques
- Lymphoma Diagnosis and Treatment
- Genomic variations and chromosomal abnormalities
- RNA and protein synthesis mechanisms
- Sperm and Testicular Function
- Prostate Cancer Treatment and Research
- MicroRNA in disease regulation
- Microtubule and mitosis dynamics
Tarbiat Modares University
2017-2024
The World Health Organization has considered the infertility as an international public health problem. Infertility affect nearly 1 in 7 couples and male component contributes to 50% of cases. There is a clear link between some cancers such testicular germ cell, prostate colon cancers. Two possibilities support this finding: 1) Cancer treatments can fertility factors 2) Genetic profile genes have been altered cancer patients. Although previously published researches mostly focused on first...
Abstract Background Hepatocellular carcinoma (HCC) is the most common type of liver cancer that occurs predominantly in patients with previous conditions. In absence an ideal screening modality, HCC usually diagnosed at advanced stage. Recent studies show loss or gain genomic materials can activate oncogenes inactivate tumor suppressor genes to predispose cells toward carcinogenesis. Here, we evaluated both copy number alteration (CNA) and RNA sequencing data 361 samples order locate...
Tyrosinases are copper-containing enzymes that initiate the melanin synthesis. They catalyze direct oxidation of L-tyrosine or L-DOPA into L-DOPAquinone.In present study, we aimed to obtain a recombinant tyrosinase with enhanced catecholase activity through site-directed mutagenesis.The coding sequence human along native signal was cloned pET-28a (+). BL-21 used as expression host and protein purified by Ni-NTA resins. Site-directed mutagenesis performed on M374 residue achieve four mutants:...
Abstract Cancer-associated death is the second leading cause of worldwide. Study involved molecular networks cancers can identify potential target for early diagnosis, efficient therapies, and predictive prognosis patients with cancer. Copy number variations are one type DNA mutations which has been connected human cancers. The CNVs be used to find regions genome in cancer phenotypes. This study aimed perform genome-wide chromosomal HCC samples hotspot disease using silico analysis. obtained...
Abstract Recent studies showed that genetic lost or gain in the genome can predispose cells toward malignancy. Hepatocellular carcinoma (HCC) is most common type of liver cancer which occurs predominantly patients with underlying chronic disease and cirrhosis. Prognosis HCC strongly connected diagnostic delay. To date, no ideal screening modality has been developed for HCC. findings demonstrated Copy number variation (CNVs) lead to activation oncogenes inactivation tumor suppressor genes...