A5053629232- Neurological Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- RNA Research and Splicing
- Nuclear Receptors and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cholinesterase and Neurodegenerative Diseases
- Cancer-related molecular mechanisms research
- Neurological Disorders and Treatments
- Cytokine Signaling Pathways and Interactions
- Asthma and respiratory diseases
- Polyoxometalates: Synthesis and Applications
- Bioactive Compounds in Plants
- RNA regulation and disease
- Physical Activity and Education Research
- Autophagy in Disease and Therapy
- Neurobiology and Insect Physiology Research
- Parkinson's Disease Mechanisms and Treatments
- Mitochondrial Function and Pathology
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2024
Vascular dementia (VaD) is a common cause of cognitive decline and vascular origin, but the precise pathological mechanisms are unknown, so effective clinical treatments have not been established. Tilianin, principal active compound total flavonoid extract from Dracocephalum moldavica L., candidate therapy for cardio-cerebrovascular diseases in China. However, its potential treatment VaD unclear. The present study aimed at investigating protective effects tilianin on exploring underlying...
Introduction Although vascular dementia (VaD) is the second most prevalent form of dementia, there currently a lack effective treatments. Tilianin, isolated from traditional drug Dracocephalum moldavica L., may protect against ischemic injury by inhibiting oxidative stress and inflammation via CaMKII-related pathways but with weak affinity CaMKII molecule. microRNAs (miRNAs), functioning in post-transcriptional regulation gene expression, play role pathological process VaD cognitive...
Long noncoding RNA and microRNA are regulatory RNAs that implicated in Alzheimer's disease, but the role of long RNA-associated competitive endogenous has not been fully elucidated. The growth arrest-specific 5 (GAS5) is a member 5'-terminal oligopyrimidine gene family may be involved neurological disorders, its disease remains unclear. This study aimed to investigate function GAS5 construct GAS5-associated network comprising potential targets. sequencing results showed was upregulated five...
Vascular dementia (VaD) is the second most common form of with uncertain mechanisms and no effective treatments. microRNAs (miRNAs) transcription factors (TFs) are considered regulatory genes involved in many diseases. Therefore, this work investigated aberrantly expressed miRNAs, TFs, corresponding target genes, their co-regulatory networks cortex rats bilateral carotid artery occlusion (2VO) to uncover potential mechanism biomarkers VaD. Differentially (DEGs), miRNAs (DEMs), TFs (DETFs)...
Alzheimer’s disease (AD) is a common neurodegenerative disorder characterized by cognitive dysfunction. The role of long non-coding RNAs (lncRNAs) with the action competitive endogenous RNA (ceRNA) in AD remains unclear. present study aimed to identify significantly differentially expressed lncRNAs (SDELs) and establish lncRNA-associated ceRNA networks via sequencing analysis quantitative real-time Polymerase Chain Reaction (qPCR) assay using transgenic mice five familial mutations. A total...
Developing multitargeted ligands as promising therapeutics for Alzheimer's disease (AD) has been considered important. Herein, a novel class of cinnamamide/ester-triazole hybrids with multifaceted effects on AD was developed based the multitarget-directed strategy. Thirty-seven were synthesized, most exhibiting significant inhibitory activity against Aβ-induced toxicity at single concentration in vitro. The optimal hybrid compound 4j inhibited copper-induced Aβ cells. its action superior to...
Vascular dementia (VaD) is a general term used to describe difficulties in memory, reasoning, judgment, and planning caused by reduced blood flow the brain consequent damage, which microRNAs (miRNAs) are involved. Dracocephalum moldavica L. ( D. ) traditionally treatment of cardiovascular diseases as well VaD, but biomolecular mechanisms underlying its therapeutic effect obscure. In present study, molecular involved VaD total flavonoids from (TFDM) were explored identification miRNA...
Hyssopus cuspidatus Boriss (H. cuspidatus) is a traditional Chinese medicine commonly used in the treatment of asthma. In present study, we applied bioinformatics techniques for mRNA-miRNA profiling to elucidate potential mechanisms H. asthma treatment. Bioactive compounds from cuspidatus, therapeutic targets and asthma-related were identified literature databases. The intersection cuspidatus-related was using STRING platform. Gene Ontology Kyoto Encyclopedia Genes Genomes pathway enrichment...