A5002954183- Liver physiology and pathology
- TGF-β signaling in diseases
- Protein Kinase Regulation and GTPase Signaling
- Biomedical Text Mining and Ontologies
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- Genetics, Bioinformatics, and Biomedical Research
- Cell Adhesion Molecules Research
- Protease and Inhibitor Mechanisms
- Pancreatic function and diabetes
- Cancer Research and Treatments
- Fibroblast Growth Factor Research
- Oral and gingival health research
- PI3K/AKT/mTOR signaling in cancer
- Growth Hormone and Insulin-like Growth Factors
- Hedgehog Signaling Pathway Studies
- Cancer-related Molecular Pathways
- Enzyme function and inhibition
- Diabetes and associated disorders
- Genetic Associations and Epidemiology
- Biotechnology and Related Fields
- Cancer-related gene regulation
- Cancer Mechanisms and Therapy
- Metabolism, Diabetes, and Cancer
Icosagen (Estonia)
2023-2024
University of Helsinki
2015-2023
University of Tartu
2016-2017
Genomic alterations affecting drug target proteins occur in several tumor types and are prime candidates for patient-specific tailored treatments. Increasingly, patients likely to benefit from targeted cancer therapy selected based on molecular alterations. The selection of a precision benefiting most is challenging but can be enhanced with integration multiple data. Data approaches prioritization have successfully integrated diverse data do not take full advantage existing literature.We...
Abstract Ras proteins play a causal role in human cancer by activating multiple pathways that promote growth and invasion. However, little is known about how induces the first diagnostic features of invasion solid tumors, including loss epithelial integrity breaching basement membrane (BM). In this study, we found oncogenic strongly promotes activation hepsin, member hepsin/TMPRSS type II transmembrane serine protease family. Mechanistically, Ras-dependent hepsin was mediated via Raf–MEK–ERK...
Article13 September 2021Open Access Source DataTransparent process Hepsin regulates TGFβ signaling via fibronectin proteolysis Denis Belitškin orcid.org/0000-0002-0032-2769 Research Programs Unit/Translational Cancer Medicine Program and Medicum, Faculty of Medicine, Biomedicum Helsinki, University Finland Search for more papers by this author Shishir M Pant orcid.org/0000-0002-2686-7898 Pauliina Munne orcid.org/0000-0002-9720-9964 Ilida Suleymanova Kati Belitškina...
Hepsin, a type II transmembrane serine protease, is commonly overexpressed in prostate and breast cancer. The hepsin protein stabilized by the Ras-MAPK pathway, and, downstream, this protease regulates degradation of extracellular matrix components activates growth factor pathways, such as hepatocyte (HGF) transforming beta (TGFβ) pathway. However, how exactly active promotes cell proliferation machinery to sustain tumor not fully understood. Here, we show that genetic deletion gene encoding...
Abstract Background: Upregulated glucose metabolism is one of the strategies cancer cells use to fuel their abnormal cell growth and division. Targeting cancer-specific transporter GLUT-1 a promising approach restrict uptake challenge metabolic needs tumor cells. Antibodies, as opposed small molecule inhibitors, are an attractive modality therapeutically target complex muti-pass membrane transporters. Here we report development antibodies that very specifically block function only GLUT-1....
Abstract Cells with slow proliferation kinetics that retain the nuclear label over long time periods–the label-retaining cells (LRCs)–represent multipotent stem in a number of adult tissues. Since identity liver LRCs (LLRCs) had remained elusive we utilized genetic approach to reveal LLRCs normal non-injured livers and characterized their regenerative properties vivo culture. We found were located biliary vessels participated regeneration but not hepatocyte injury. In culture experiments...
Event Abstract Back to Characterization of monoclonal ZnT8-specific antibody Julia Ustinova1*, Denis Belitskin2, Erkki Juronen3, Eva Zusinaite4, Meeme Utt1 and Raivo Uibo1 1 Institute Biomedicine, University Tartu, Estonia 2 Molecular Cell Biology, 3 Department 4 Technology, Immune-mediated destruction insulin-producing beta cells pancreas leads autoimmune type diabetes mellitus (T1D). Recently, ZnT8 (zinc transporter 8) has been identified as an target in T1D. is expressed the pancreatic...
<div>Abstract<p>Ras proteins play a causal role in human cancer by activating multiple pathways that promote growth and invasion. However, little is known about how Ras induces the first diagnostic features of invasion solid tumors, including loss epithelial integrity breaching basement membrane (BM). In this study, we found oncogenic strongly promotes activation hepsin, member hepsin/TMPRSS type II transmembrane serine protease family. Mechanistically, Ras-dependent hepsin was...
<p>Including Supplementary Materials and Methods, Figures Figure Legends 1-5, Tables 1-7, References</p>
<p>Including Supplementary Materials and Methods, Figures Figure Legends 1-5, Tables 1-7, References</p>
Abstract Background: Alterations in tumor cell metabolism are one of the central processes guiding cancer progression. The increased glucose dependence cells, also known as Warburg effect, opens possibility to therapeutically target glycolytic pathway and challenge metabolic needs cells. We generated 24 monoclonal antibodies targeting main transporter on cells - SLC2A1 (GLUT1). evaluated ability affect fitness alone combination with OXPHOS inhibitors find clinically applicable therapeutics...
<div>Abstract<p>Ras proteins play a causal role in human cancer by activating multiple pathways that promote growth and invasion. However, little is known about how Ras induces the first diagnostic features of invasion solid tumors, including loss epithelial integrity breaching basement membrane (BM). In this study, we found oncogenic strongly promotes activation hepsin, member hepsin/TMPRSS type II transmembrane serine protease family. Mechanistically, Ras-dependent hepsin was...