A5055732582- Chemical Synthesis and Analysis
- Click Chemistry and Applications
- Computational Drug Discovery Methods
- Carbohydrate Chemistry and Synthesis
- Innovative Microfluidic and Catalytic Techniques Innovation
- Soft Robotics and Applications
- Monoclonal and Polyclonal Antibodies Research
- Chemical synthesis and alkaloids
- Modular Robots and Swarm Intelligence
- Asymmetric Synthesis and Catalysis
- Fluorine in Organic Chemistry
- Advanced Battery Technologies Research
- Distributed Control Multi-Agent Systems
- Peptidase Inhibition and Analysis
- Chemistry and Chemical Engineering
- Antimicrobial Peptides and Activities
- Micro and Nano Robotics
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- Synthetic Organic Chemistry Methods
- Various Chemistry Research Topics
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- Advancements in Battery Materials
- Underwater Vehicles and Communication Systems
- Advanced Battery Materials and Technologies
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Bucknell University
2021-2024
Indiana University – Purdue University Indianapolis
2009-2023
University of Maryland, College Park
2017-2020
University of Indianapolis
2003-2020
Princeton University
2013-2019
University of Havana
2017
Colorado College
2017
Santa Clara University
2017
University of Waterloo
2014-2015
Grand Rapids Community College
2010
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTSolid-Phase Unnatural Peptide Synthesis (UPS)Martin J. O'Donnell, Changyou Zhou, and William L. ScottView Author Information Department of Chemistry, Indiana University−Purdue University at Indianapolis, 46202 Technology Core Research, Lilly Research Laboratories Corporate Center, Eli Company 46285 Cite this: Am. Chem. Soc. 1996, 118, 25, 6070–6071Publication Date (Web):June 26, 1996Publication History Received16 January 1996Published...
Modeling soft robots that move on surfaces is challenging from a variety of perspectives. A recent formulation by Bergou et al. rod theory exploits new developments in discrete differential geometry offers an attractive, numerically efficient avenue to help overcome some these challenges. Their example elastic theory. In this article, we consider planar version al.'s and, with the works Lagrange's equations motion for constrained systems particles, show how it can be used model are composed...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAsymmetric synthesis of the enkephalinase inhibitor thiorphanDavid A. Evans, David J. Mathre, and William L. ScottCite this: Org. Chem. 1985, 50, 11, 1830–1835Publication Date (Print):May 1, 1985Publication History Published online1 May 2002Published inissue 1 1985https://pubs.acs.org/doi/10.1021/jo00211a008https://doi.org/10.1021/jo00211a008research-articleACS PublicationsRequest reuse permissionsArticle Views1795Altmetric-Citations84LEARN ABOUT...
Thrombin cleaves fibrinopeptides from fibrinogen, converting it to fibrin monomer, and activates factor XIII, which catalyzes the formation of intermolecular epsilon-(gamma-glutamyl)-lysine bonds stabilize polymer. The XIIIa-catalyzed polymers during clotting plasma purified fibrinogen in vivo was followed by a sodium dodecyl sulfate agarose gel technique, an increase both amount size gamma-chain cross-linked demonstrated before visible clot formation. Plasma patients presenting with acute...
Motivated by problems of pursuit and evasion in coordinated multi-agent systems, we present a model pursuit, herding for three agents: single pursuer, e.g. bear, chooses target point along the line connecting two evaders, mother caribou her calf, each choose strategy that trades off herding. The is based on feedback control constant speed steered particles plane. Dynamics over reduced set shape variables are defined. Parallel-motion equilibria studied, with stability analysis analytic...
Abstract Major disturbances can temporarily remove factors that otherwise constrain population abundance and distribution. During such windows of relaxed top‐down and/or bottom‐up control, ungulate populations grow rapidly, eventually leading to resource depletion density‐dependent expansion into less‐preferred habitats. Although many studies have explored the demographic outcomes ecological impacts these processes, fewer examined individual‐level mechanisms by which they occur. We...
ADVERTISEMENT RETURN TO ISSUEPREVPerspectiveNEXTDistributed Drug Discovery, Part 1: Linking Academia and Combinatorial Chemistry to Find Leads for Developing World DiseasesWilliam L. Scott* Martin J. O'DonnellView Author Information Department of Chemical Biology, Indiana University-Purdue University Indianapolis, 46202-3274* To whom correspondence should be addressed. E-mail: [email protected]Cite this: Comb. Chem. 2009, 11, 1, 3–13Publication Date (Web):December 23, 2008Publication History...
Movement in echinoderms is facilitated by the coordinated activity of thousands individually addressable and reversibly adhesive tube feet. To investigate potential applicability these unique biological actuators as a locomotory structure for robotics applications, we describe here design, fabrication, evaluation an elastomeric structural analogue. The synthetic feet were modeled bistable deformable domes, containing embedded magnet to facilitate reversible attachment ferromagnetic...
A wide variety of highly substituted lactam containing peptidomimetic scaffolds are prepared by solid-phase synthesis from a single, versatile class resin-bound aldehyde intermediates (1). These include monocyclics 3, bicyclics 4, tricyclics 5, and tetracyclics 6. The key intermediate 1 is readily synthesized natural or unnatural α-amino acids. synthetic procedures permit the construction large diversity substitution patterns for ready use in combinatorial chemistry. In every case, release...
Distributed Drug Discovery (D3) proposes solving large drug discovery problems by breaking them into smaller units for processing at multiple sites. A key component of the synthetic and computational stages D3 is global rehearsal prospective reagents their subsequent use in creation virtual catalogs molecules accessible simple, inexpensive combinatorial chemistry. The first section this article documents feasibility Discovery. Twenty-four alkylating agents were rehearsed United States,...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal synthesis of (+-)-lucidulineW. L. Scott and D. A. EvansCite this: J. Am. Chem. Soc. 1972, 94, 13, 4779–4780Publication Date (Print):June 1, 1972Publication History Published online1 May 2002Published inissue 1 June 1972https://doi.org/10.1021/ja00768a083Request reuse permissionsArticle Views1670Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article downloads since November 2008 (both PDF...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStrained heterocyclic systems. IV. 1,2-Dihydrocyclobuta[b]quinoline and derivativesJ. Hodge Markgraf, Robert J. Katt, William L. Scott, Russell N. ShefrinCite this: Org. Chem. 1969, 34, 12, 4131–4133Publication Date (Print):December 1, 1969Publication History Published online1 May 2002Published inissue 1 December 1969https://doi.org/10.1021/jo01264a081RIGHTS & PERMISSIONSArticle Views97Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are...
The Distributed Drug Discovery (D3) program trains students in three drug discovery disciplines (synthesis, computational analysis, and biological screening) while addressing the important challenge of discovering leads for neglected diseases. This article focuses on implementation synthesis component second-semester undergraduate organic laboratory. educational was started at IUPUI 2003 has been carried out over 23 semesters with 65 lab sections by >1200 students. Since chemistry is most...
Remote amide bonds in simple N-acyl amino acid or peptide derivatives 1 can be surprisingly unstable hydrolytically, affording, solution, variable amounts of 3 under mild acidic conditions, such as trifluoroacetic acid/water mixtures at room temperature. This observation has important implications for the synthesis this class compounds, which includes N-terminal-acylated peptides. We describe factors contributing to instability and how predict control it. The is a function remote acyl group,...
The solid-phase synthesis of "unnatural" amino aldehydes, ketones, peptide and ketones was accomplished from commercially available resin in a series room temperature reactions. initial step involved addition an side chain to the N-terminus benzophenone imine-activated Weinreb resin-bound acid or derivative. alkylated imine hydrolyzed, amine converted Boc-, Cbz-, naphthoyl substrate then cleaved with DIBAL-H Grignard reagent give aldehyde, ketone, ketone products. Twenty-four reactions were...
A new carrier molecule, NH2OCH2CO-(Gly)3-[Lys(H-Ser-)]5-Gly-OH, has been synthesized to facilitate the preparation of protein conjugates defined structure. Special features are as follows: (i) (aminooxy)-acetyl a terminal group, which reacts specifically form an oxime bond under very mild conditions with aldehyde group placed on in prior step; (ii) spacer three Gly residues; and (iii) set five Lys residues, each is acylated Ser residue. second HCO-m-C6H4CH =...
We propose and analyze a dynamic model of pursuit evasion on the plane with single pursuer heterogeneous group evaders. Heterogeneity in evaders is expressed as heterogeneity individual maximum speeds. The goal to capture evader minimum time. each avoid or else delay for long possible. Two cases sensing among agents are considered: global (all-to-all) sensing, local (radius-limited) sensing. present strategies optimal target selection that achieve bounded prove conditions under which they...