A5038397694- Cancer-related Molecular Pathways
- Epigenetics and DNA Methylation
- Reproductive System and Pregnancy
- Liver physiology and pathology
- Estrogen and related hormone effects
- MicroRNA in disease regulation
- Genetic factors in colorectal cancer
- Cervical Cancer and HPV Research
- Microtubule and mitosis dynamics
- Glycosylation and Glycoproteins Research
- Kruppel-like factors research
- Hepatocellular Carcinoma Treatment and Prognosis
- Caveolin-1 and cellular processes
- Endometrial and Cervical Cancer Treatments
- RNA modifications and cancer
- Proteoglycans and glycosaminoglycans research
- Microfluidic and Bio-sensing Technologies
- Force Microscopy Techniques and Applications
- Bladder and Urothelial Cancer Treatments
- Erythrocyte Function and Pathophysiology
- Blood properties and coagulation
- Viral gastroenteritis research and epidemiology
- Viral Infections and Immunology Research
- Lung Cancer Treatments and Mutations
- Pediatric Hepatobiliary Diseases and Treatments
University of Groningen
2018-2025
Institute of Molecular Biology and Biophysics
2025
University of Science and Technology Liaoning
2024
Tibet University
2024
Guangdong Pharmaceutical University
2024
Qinghai Normal University
2023
Tangshan People's Hospital
2022
Rijksmuseum
2021
Guangdong Medical College
2019
Southern Medical University
2017-2018
Abstract Purpose: Research has revealed abnormal activation of the hedgehog pathway in human malignancies. The present study was undertaken to examine expression and functional involvement endometrial tissues. Experimental Design: sonic (Shh), patched (Ptch), Smoothened (Smo), Gli1 examined various tissues carcinoma cell lines. effect signaling on proliferation lines also examined. Results: Shh, Ptch, Smo, very weak normal endometrium, but increased hyperplasia stepwisely with significant...
Abstract Purpose: Although several gene abnormalities have been reported in endometrial carcinoma, the genetic alterations not fully elucidated. Recent studies revealed frequent activating mutations of for BRAF, an effector Ras protein mitogen-activated kinase pathway, malignancies. However, prevalence and significance BRAF carcinoma remain unclear. Experimental Design: We examined exons 11 15 97 cases (endometrioid type, 78; nonendometrioid 19), 9 atypical hyperplasia, 20 normal endometrium...
To counteract hand, foot, and mouth disease-causing viruses such as enterovirus A71 coxsackievirus A6, virus-like particles (VLPs) have emerged a leading contender for the development of multivalent vaccine. However, VLPs shown rapid conversion from highly immunogenic state to less low particle integrity lifetimes compared inactivated virus vaccines, thus raising concerns about their overall stability. Here, we produce investigate capsid stability using cryogenic electron microscopy...
To examine the sex steroid-dependent growth mechanisms of human endometrium, expression steroid receptor coactivators [steroid coactivator-1 (SRC-1) and p300/CREB-binding protein (p300/CBP)] corepressors (nuclear corepressor silencing mediator for retinoid thyroid hormone receptors) was examined by immunohistochemistry, using 50 samples normal endometria, compared with that estrogen receptors (ER), progesterone (PR), proliferation marker Ki-67. In addition, actual binding to ER or PR...
Abstract BACKGROUND To examine the steroid hormone dependent growth mechanism of human endometrial hyperplasia and carcinoma, expression levels receptor cofactors, such as coactivators (steroid coactivator 1 [SRC‐1] p300/cyclic AMP‐response element‐binding protein (p300/CBP]) corepressors (nuclear corepressor [NCoR] silencing mediator for retinoid thyroid‐hormone receptors [SMRT]), were investigated. METHODS The cofactors examined immunohistochemically using 20 samples normal endometria, 36...
Impaired mismatch repair (MMR) is reportedly crucial in the early stages of endometrial carcinogenesis. Although estrogen exposure considered an important risk factor for carcinoma, relationship between and MMR activity remains undetermined. The present study was undertaken to elucidate effect on normal malignant cells. expression proteins, hMLH1 hMSH2, its correlation with examined using immunohistochemical immunofluorescent techniques. estradiol (E2) hMLH1/hMSH2 protein/mRNA vitro two...
Resveratrol (Res) is a multi-functional polyphenol compound that has protective functions in the cardiovascular and neurodegenerative diseases. This study was designed to evaluate effect of Res on dexamethasone-induced osteogenic differentiation bone mineralization zebrafish (Danio rerio). Our results showed dexamethasone sodium phosphate (Dex) exposure decrease green fluorescence areas integrated optic density (IOD) values head bones larvae TG strain (SP7: EGFP) dose-dependent manner could...
Bladder cancer (BCa) is one of the most common cancers in urinary system among world. Previous studies suggested that TMEM40 expression level was significantly associated with clinicopathological parameters including histological grade, clinical stage and pT status bladder cancer. However, molecular mechanism BCa remains poorly understood. Real-time quantitative RT-PCR (qRT-PCR) western blot (WB) were used to examine levels tissues, paired non-cancer tissues cell lines. A series experiments,...
Abstract High-risk human papillomaviruses (HPVs) cause various cancers. While type-specific prophylactic vaccines are available, additional anti-viral strategies highly desirable. Initial HPV cell entry involves receptor-switching induced by structural capsid modifications. These modifications initiated interactions with cellular heparan sulphates (HS), however, their molecular nature and functional consequences remain elusive. Combining virological assays hydrogen/deuterium exchange mass...
Transmembrane protein 40 (TMEM40) is a 23‑kDa and its association with tongue squamous cell carcinoma (TSCC) remains unclear. This study aimed to investigate the expression clinical significance of TMEM40 in TSCC roles cells. Immunohistochemical analysis was performed detect levels 60 tissue samples. Furthermore, overexpressed inhibited two lines by transfection pEZ‑M98‑TMEM40 plasmid or small interfering RNA, respectively. Cell Counting Kit‑8 colony formation assays were used effects on...
Human Pinx1 protein, associated with shelterin proteins, is widely revealed as a haploinsufficient tumor suppressor. Growing evidence has manifested the deregulation of PinX1 in distinct cancers. Nonetheless, loss status and its diagnostic, prognostic clinicopathological significance Basal-like breast cancer are still unclear. In present study, expression levels tissues were investigated by qRT-PCR immunoblotting assays. Then immunohistochemistry (IHC) was performed to detect on tissue...
Prolonged storage will alter the biophysical properties of red blood cells (RBCs), and it decreases quality stored for transfusion. It has been known that less deformable aged RBCs can be separated by margination, but recognition time from separation efficiency stiff is still a challenge. In this study, we realized enhanced normal controlling channel cross section demonstrated deduced percentage in RBCs. This technology helps to reveal regulation on RBC aging mechanism offer new method...
The majority of nonbacterial gastroenteritis in humans and livestock is caused by noroviruses. Like most RNA viruses, frequent mutations result various norovirus variants. strain-dependent binding profiles noroviruses to fucose are supposed facilitate infection. It remains unclear, however, what the molecular mechanism behind functioning is. In this study, applying atomic force microscopy (AFM) nanoindentation technology, we studied norovirus-like particles (noroVLPs) three distinct human We...
Large language models (LLMs) have achieved impressive linguistic capabilities. However, a key limitation persists in their lack of human-like memory faculties. LLMs exhibit constrained retention across sequential interactions, hindering complex reasoning. This paper explores the potential applying cognitive psychology's working frameworks, to enhance LLM architecture. The limitations traditional designs are analyzed, including isolation distinct dialog episodes and persistent links. To...