A5061678035- RNA Research and Splicing
- Viral Infections and Immunology Research
- interferon and immune responses
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- RNA regulation and disease
- Endoplasmic Reticulum Stress and Disease
Centre International de Recherche en Infectiologie
2022-2025
Université Claude Bernard Lyon 1
2022-2025
Centre National de la Recherche Scientifique
2022-2025
Inserm
2022-2025
École Normale Supérieure de Lyon
2025
Abstract The nonsense-mediated mRNA decay (NMD) pathway triggers the degradation of defective mRNAs and governs expression with specific characteristics. Current understanding indicates that NMD is often significantly suppressed during viral infections to protect genome. In numerous viruses, this inhibition achieved through direct or indirect interference RNA helicase UPF1, thereby promoting replication enhancing pathogenesis. study, we employed biochemical, biophysical assays cellular...
ISG20 is a broad-spectrum antiviral protein capable of specifically degrading viral RNA. Here, we examine the different strategies developed by viruses to evade ISG20-mediated restriction, shedding light on how this exonuclease distinguishes between self and non-self RNAs, highlighting many questions that remain unanswered.
ISG20 is an IFN-induced 3′–5′ RNA exonuclease that acts as a broad antiviral factor. At present, the features expose to remain unclear, although recent studies have pointed modulatory role of epitranscriptomic modifications in susceptibility target RNAs ISG20. These findings raise question how cellular RNAs, on which these are abundant, cope with To obtain unbiased perspective this topic, we used RNA-seq and biochemical assays identify elements regulate behavior against analyses not only...
The Nonsense-mediated mRNA decay (NMD) pathway triggers the degradation of defective mRNAs and governs expression with specific characteristics. Current understanding indicates that NMD is often significantly suppressed during viral infections to protect genome. In numerous viruses, this inhibition achieved through direct or indirect interference RNA helicase UPF1, thereby promoting replication enhancing pathogenesis. study, we employed biochemical, biophysical assays, cellular...
ABSTRACT ISG20 is an interferon-induced 3’-to-5’ RNA exonuclease that acts as a broad antiviral factor. At present, the features expose to remain unclear, although recent studies have pointed modulatory role of epitranscriptomic modifications in susceptibility target RNAs ISG20. These findings raise question how cellular RNAs, on which these are abundant, cope with To obtain unbiased perspective this topic, we used RNAseq and biochemical assays identify elements regulate behavior against The...