Angela M. O’Connor

ORCID: 0000-0002-0053-1835
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About
Contact & Profiles
Research Areas
  • Neuroscience and Neuropharmacology Research
  • Stress Responses and Cortisol
  • Genetic Neurodegenerative Diseases
  • Gene expression and cancer classification
  • Neuroendocrine regulation and behavior
  • Bioinformatics and Genomic Networks
  • Neurological and metabolic disorders
  • Neurogenesis and neuroplasticity mechanisms
  • Long-Term Effects of COVID-19
  • Wnt/β-catenin signaling in development and cancer
  • Connective Tissue Growth Factor Research
  • Biomedical Text Mining and Ontologies
  • Memory and Neural Mechanisms
  • Machine Learning in Bioinformatics
  • Global Educational Policies and Reforms
  • Education Systems and Policy
  • Neuroscience of respiration and sleep
  • Tryptophan and brain disorders
  • Adipose Tissue and Metabolism
  • Fibroblast Growth Factor Research
  • Teacher Education and Leadership Studies
  • Animal Behavior and Welfare Studies

University of Michigan
2018-2025

The University of Sydney
2014-2019

Stress is a major influence on mental health status; the ways that individuals respond to or copes with stressors determine whether they are negatively affected in future. responses established by an interplay between genetics, environment, and life experiences. Psychosocial stress particularly impactful during adolescence, critical period for development of mood disorders. In this study we compared two established, selectively-bred Sprague Dawley rat lines, "internalizing" bred Low...

10.1016/j.ynstr.2024.100651 article EN cc-by-nc-nd Neurobiology of Stress 2024-05-30

Transcriptional profiling has become a common tool for investigating the nervous system. During analysis, differential expression results are often compared to functional ontology databases, which contain curated gene sets representing well-studied pathways. This dependence can cause neuroscience studies be interpreted in terms of pathways documented better studied tissues (

10.1101/2024.04.05.588301 preprint EN cc-by-nc-nd bioRxiv (Cold Spring Harbor Laboratory) 2024-04-10

Long Covid is a debilitating condition that has been well-documented over the past 4 years and shares many similarities with other post-viral chronic illnesses. Despite this, clinicians are not confident in recognising signs of Covid, or effectively managing symptoms their patients. This paper presents single patient case report from biomedical researcher who had for 2 years; it written relatively plain language to be accessible both patients across multiple specialities. The author ability...

10.20944/preprints202401.1621.v1 preprint EN 2024-01-23

Environmental enrichment can dramatically influence the development and function of neural circuits. Further, has been shown to successfully delay onset symptoms in models Huntington's disease 1-4, suggesting environmental factors evoke a neuroprotective effect against progressive, cellular level damage observed neurodegenerative disorders. The ways which an animal be environmentally enriched, however, vary considerably. there is no straightforward manner effects assessed: most methods...

10.3791/52225 article EN Journal of Visualized Experiments 2014-12-29

Environmental enrichment can dramatically affect both the development and function of neural circuits. This is accomplished, at least in part, by regulation inhibitory cellular networks related extracellular matrix glycoprotein structures known as perineuronal nets. The degree to which enhanced housing influence brain areas involved planning execution actions not well known. We examined effect enriching mice from birth on parvalbumin expression net formation developing adult striatum. input...

10.3389/fnana.2019.00090 article EN cc-by Frontiers in Neuroanatomy 2019-10-24

Environmental enrichment can dramatically influence the development and function of neural circuits. Further, has been shown to successfully delay onset symptoms in models Huntington's disease 1-4, suggesting environmental factors evoke a neuroprotective effect against progressive, cellular level damage observed neurodegenerative disorders. The ways which an animal be environmentally enriched, however, vary considerably. there is no straightforward manner effects assessed: most methods...

10.3791/52225-v article EN Journal of Visualized Experiments 2014-12-29

Abstract Stress is a major influence on mental health status; the ways that individuals respond to or copes with stressors determine whether they are negatively affected in future. responses established by an interplay between genetics, environment, and life experiences. Psychosocial stress particularly impactful during adolescence, critical period for development of mood disorders. In this study we compared two established, selectively-bred Sprague Dawley rat lines, “internalizing” bred Low...

10.1101/2023.10.03.560702 preprint EN cc-by-nc-nd bioRxiv (Cold Spring Harbor Laboratory) 2023-10-04
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