A5052524569- Glaucoma and retinal disorders
- Cerebrospinal fluid and hydrocephalus
- Wnt/β-catenin signaling in development and cancer
- Traumatic Brain Injury and Neurovascular Disturbances
- Electrospun Nanofibers in Biomedical Applications
- Ocular Surface and Contact Lens
- Tissue Engineering and Regenerative Medicine
- Infrared Thermography in Medicine
- Retinal Diseases and Treatments
- Veterinary Medicine and Surgery
- Fetal and Pediatric Neurological Disorders
- Corneal Surgery and Treatments
- Animal health and immunology
- Corneal surgery and disorders
- Veterinary Pharmacology and Anesthesia
- Wound Healing and Treatments
- Veterinary Oncology Research
- Salivary Gland Disorders and Functions
- Cerebral Venous Sinus Thrombosis
- Flavonoids in Medical Research
- Optical Coherence Tomography Applications
- Neurosurgical Procedures and Complications
- Infectious Aortic and Vascular Conditions
- Fibroblast Growth Factor Research
- Cancer Diagnosis and Treatment
Kerala Veterinary and Animal Sciences University
2016-2023
NYU Langone Health
2019-2022
New York University
2020-2021
ORCID
2021
With the increasing use of animal-based biomaterials for regenerative medical applications, need their safety assessment is paramount. A porcine cholecyst-derived scaffold (CDS), intended as a muscle repair graft, prepared by nondetergent/enzymatic method was engrafted in rat abdominal wall defect model. Host tissue–scaffold interface samples were collected 2, 8, and 16 weeks postimplantation evaluated histopathology, immunohistochemistry, electron microscopy. The nature tissue reaction...
Purpose: Intraocular pressure (IOP) is currently the only modifiable risk factor for glaucoma, yet glaucoma can continue to progress despite controlled IOP. Thus, development of neurotherapeutics remains an unmet need. Scutellarin a flavonoid that exert neuroprotective effects in eye and brain. Here, we investigated neurobehavioral scutellarin treatment chronic IOP elevation model. Methods: Ten adult C57BL/6J mice were unilaterally injected with optically clear hydrogel into anterior chamber...
Background and Aim: Ulcerative corneal lesions are common ocular affections encountered in veterinary ophthalmology, having a higher incidence dogs with brachycephalic conformation. Prompt effective diagnosis repair necessary to avoid perforation restore vision. Corneal wound healing is complex phenomenon often resulting vision impairment as consequence of fibrosis pigmentation. The present study investigated the efficacy decellularized gamma-irradiated bovine omentum an extracellular matrix...
Abstract Gpr125, encoded by Adgra3 , is an orphan adhesion G-protein coupled receptor (aGPCR) implicated in modulating Wnt signaling and planar polarity. Here we establish both physiological pathological roles for Gpr125. We show that mice lacking Gpr125 or its domains display ocular phenotype with many hallmarks of human dry eye syndrome. These include squinting, abnormal lacrimation, mucus accumulation, swollen eyelids inflammatory infiltration lacrimal meibomian glands. Utilizing a...
Introduction: Lameness is a severe clinical issue in racing animals, which can severely affect their health. Therefore, identifying the cause of lameness crucial step its diagnosis. Animals with subclinical etiologies are difficult to be identified field conditions. Infrared thermal imaging an advanced diagnostic tool for locating injury site. Although sports injuries regular buffalo bulls used traditional villages, fracture diagnosis challenging when examination, evaluation, and palpation...
Corneal ulcers are one of the most common eye affection in domestic animals, especially dogs. In preclinical studies, porcine corneas were used regularly as an animal model due to its relative similarity human cornea and availability great numbers from slaughter houses. present study, decellularised was for corneal grafting acellular scaffold graft material a case presented with deep ulcer. The efficiency analysed on day presentation, days 7, 14, 21 60 post grafting, based clarity, oedema,...
The lamina cribrosa (LC) has an important role in the pathophysiology of ocular diseases. purpose this study is to characterize vivo, noninvasively, and 3D structure LC healthy non-human primates (NHPs).Spectral-domain optical coherence tomography (OCT; Leica, Chicago, IL) scans optic nerve head (ONH) were obtained from adult rhesus macaques monkeys. Using a previously reported semi-automated segmentation algorithm, microstructure measurements assessed central peripheral regions equal area,...
Recent evidence suggests the existence of a functional glymphatic system in optic nerve. Insulin resistance central nervous (CNS-IR) has been implicated neurodegenerative conditions. Its mechanism remains unclear though one candidate involves dysregulation cerebrospinal fluid (CSF). Here, we investigated if CNS-IR affects CSF flow visual pathway by measuring spatiotemporal profiles dynamics using gadolinium-enhanced MRI following intrathecal administration specific insulin receptor blocker,...
Background: Streamlining surgical approaches for various neoplasms in dogs utilising tumour node metastasis (TNM) staging and assessment of quality life (QOL) a cancer patient has always been challenge veterinary oncology. The study was intended to assess TNM as prognostic indicator basis decision canine mammary superficial neoplasms. Methods: Thirty six cases were studied three groups based on histopathology the excisional biopsy samples correlated with stages response treatment assessed...