A5060937432- Cancer Cells and Metastasis
- Wnt/β-catenin signaling in development and cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Ocular Surface and Contact Lens
- Cytokine Signaling Pathways and Interactions
- Salivary Gland Disorders and Functions
- Synthesis and Biological Evaluation
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Biomarkers in Disease Mechanisms
- Cancer therapeutics and mechanisms
- Estrogen and related hormone effects
- Congenital heart defects research
- Metastasis and carcinoma case studies
- TGF-β signaling in diseases
- Immunotherapy and Immune Responses
- Metabolism, Diabetes, and Cancer
Kettering University
2024
Memorial Sloan Kettering Cancer Center
2024
New York University
2020-2022
University of Calabria
2016-2017
Together with estrogen receptors ERα and ERβ, the G protein-coupled receptor (GPER) mediates important pathophysiological signaling pathways induced by estrogens is currently regarded as a promising target for ER-negative (ER-) triple-negative (TN) breast cancer. Only few selective GPER modulators have been reported to date, their use in cancer cell lines has often led contradictory results. Herein we report application of virtual screening cell-based studies identification new chemical...
Abstract Gpr125 is an orphan G-protein coupled receptor, with homology to cell adhesion and axonal guidance factors, that implicated in planar polarity control of movements. By lineage tracing we demonstrate a highly specific marker bipotent mammary stem cells the embryo multiple long-lived unipotent basal progenitors perinatal postnatal glands. Nipple-proximal Gpr125+ express transcriptomic profile indicative chemo-repulsion movement, whereas concentrated at invasive ductal tips display...
Abstract In the tumor microenvironment (TME) cancer cells engage dynamically with stromal component in promoting progression and metastasis formation that are accompanied by intratumor fibrosis. Extensive extracellular matrix (ECM) remodeling stiffness boost fibrosis which co-occurs poor immune infiltration. Very little is known about cross-interactions between stroma. A better understanding of this dynamic relationship may advance development new therapies. Transforming growth factor...
Abstract Gpr125, encoded by Adgra3 , is an orphan adhesion G-protein coupled receptor (aGPCR) implicated in modulating Wnt signaling and planar polarity. Here we establish both physiological pathological roles for Gpr125. We show that mice lacking Gpr125 or its domains display ocular phenotype with many hallmarks of human dry eye syndrome. These include squinting, abnormal lacrimation, mucus accumulation, swollen eyelids inflammatory infiltration lacrimal meibomian glands. Utilizing a...
Obesity is increasingly recognized as an oncogenic factor. Adipose tissue active metabolic and endocrine organ that secretes many adipocytokines, which act key mediators in several obesity‐associated diseases. Among these adiponectin has been proposed having a role the pathogenesis of cardiovascular disease type 2 diabetes along with other diseases such malignancies, including breast cancer. An inverse correlation reported between obesity adiponectin, for low levels represent risk factor...