A5036460505- Adipokines, Inflammation, and Metabolic Diseases
- Cytokine Signaling Pathways and Interactions
- Biomarkers in Disease Mechanisms
- Cancer, Lipids, and Metabolism
- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- MicroRNA in disease regulation
- Histone Deacetylase Inhibitors Research
- Regulation of Appetite and Obesity
- Metabolism, Diabetes, and Cancer
- Estrogen and related hormone effects
- Cancer-related molecular mechanisms research
- FOXO transcription factor regulation
- Pharmacological Effects and Toxicity Studies
- Adipose Tissue and Metabolism
- NF-κB Signaling Pathways
- Nanoparticle-Based Drug Delivery
- Epilepsy research and treatment
- Advanced Drug Delivery Systems
- PARP inhibition in cancer therapy
- Single-cell and spatial transcriptomics
- Supramolecular Self-Assembly in Materials
- Prion Diseases and Protein Misfolding
- Polydiacetylene-based materials and applications
- Growth Hormone and Insulin-like Growth Factors
University of Calabria
2015-2025
University of Michigan
2022
Institute for Biomedical Research and Innovation
2019
National Research Council
2019
Institute of Neurological Sciences
2019
Exosomes—small membrane vesicles secreted by both normal and malignant cells upon fusion of endosomal multivesicular bodies (MVBs) with the plasma membrane—play an important role in cell-to-cell communication. During last decade, several reports have highlighted involvement these nanovesicles many aspects breast cancer development progression, but extracellular signals governing their generation not been completely unraveled. Here, we investigated obesity hormone leptin, a well-known...
Abstract Background Breast cancer is the second leading cause of death among women after lung cancer. Despite improvement in prevention and therapy, breast still remains a threat, both for pre- postmenopausal women, due to development drug resistance. To counteract that, novel agents regulating gene expression have been studied hematologic solid tumors. The Histone Deacetylase (HDAC) inhibitor Valproic Acid (VA), used epilepsy other neuropsychiatric diseases, has demonstrated strong...
Adipose tissue is a metabolic and endocrine organ that secretes bioactive molecules called adipocyto-kines. Among these, adiponectin has crucial role in obesity-associated breast cancer. The key molecule of signaling AMPK, which mainly activated by liver kinase B1 (LKB1). Here, we demonstrated estrogen receptor-α (ERα)/LKB1 interaction may negatively interfere with the LKB1 capability to phosphorylate AMPK inhibit its downstream TSC2/mTOR/p70S6k. In adiponectin-treated MCF-7 cells, was not...
The loading of chemotherapics into smart nanocarriers that simultaneously possess more than one useful property for specifically targeting a tumor site improves their therapeutic effectiveness, reducing side effects. Hence, we proposed combined approach the treatment human breast cancer (BC) consisting co-encapsulation doxorubicin and curcumin or quercetin multifunctional niosomes, which results in prolonged blood circulation an ability to spontaneously accumulate at (passive target)...
In the breast tumor microenvironment (TME), adipocytes exert a selective pressure on behavior of cancer stem cells (BCSCs), which are involved in endocrine therapy resistance. obesity, secrete reduced levels adiponectin, promotes growth and progression ERα-positive (BC). Here, we examined how low adiponectin affect enrichment BCSC subpopulation mechanisms contributing to maintenance resistance BC. Flow cytometry, qRT-PCR, Western blotting analysis were performed assess stemness, cell cycle,...
Aberrant leptin (Ob) signaling, a hallmark of obesity, has been recognized to influence breast cancer (BC) biology within the tumor microenvironment (TME). Here, we evaluated impact receptor (ObR) knockdown in affecting BC phenotype and mediating interaction between cells macrophages, most abundant immune TME. The stable ObR (ObR sh) ERα-positive ERα-negative turned into less aggressive one, as evidenced by vitro vivo models. In xenograft tumors co-culture experiments circulating monocytes...
Glioblastoma multiforme (GBM) is the most malignant form of glioma, which represents one commonly occurring tumors central nervous system. Despite continuous development new clinical therapies against this malignancy, it still remains a deadly disease with very poor prognosis. Here, we demonstrated existence biologically active interaction between leptin and Notch signaling pathways that sustains GBM progression. We found expression its receptors was significantly higher in human...
Triple-negative breast cancers (TNBCs) are frequently poorly differentiated with high propensity for metastasis. Enhancer of zeste homolog 2 (EZH2) is the lysine methyltransferase polycomb repressive complex that mediates transcriptional repression in normal cells and cancer through H3K27me3. However, H3K27me3-independent non-canonical functions EZH2 incompletely understood. We reported phosphorylation at T367 by p38α induces TNBC metastasis an manner. Here, we show cytosolic methylates 139...
Endocrine therapy (ET) has improved the clinical outcomes of Estrogen receptor alpha-positive (ERɑ +) breast cancer (BC) patients, even though resistance to ET remains a issue. Mutations in hormone-binding domain ERɑ represent an acquired intrinsic mechanism resistance. However, latter also depends on multiple functional interactions between BC cells and tumor microenvironment (TME). Here, we investigated how most common Y537S-ERɑ mutation may influence behavior fibroblasts, prominent...
Abstract Adiponectin is the major adipocytes‐secreted protein involved in obesity‐related breast cancer growth and progression. We proved that adiponectin promotes proliferation ERα‐positive cells, through ERα transactivation recruitment of LKB1 as ERα‐coactivator. Here, we showed adiponectin‐mediated enhances E‐cadherin expression. Thus, investigated molecular mechanism which ERα/LKB1 complex may modulate expression E‐cadherin, influencing tumor growth, progression distant metastasis....
Neuroendocrine differentiation of prostate cancer, induced by androgen deprivation therapy, is mainly related to advanced disease and poor clinical outcome. Genetic epigenetic alterations are the key elements carcinogenesis. A group compounds able induce changes in this sense inhibitors histone deacetylase, which it belongs valproic acid (VPA). In present paper, we evaluated role molecule on neuroendocrine LNCaP cells together with effect proliferation survival signals.Cell growth was...
Prostate cancer (PCa) is the second most common male cancer. Its incidence derives from interaction between modifiable and non-modifiable factors. The progression of prostate into a more aggressive phenotype associated with chronic inflammation increased ROS production. For their biological properties, some phytochemicals fruits vegetable emerge as promise strategy for delay. These bioactive compounds are found in highest amounts peels seeds. Poncirus trifoliata (L.) Raf. (PT) has been...
Abstract INTRODUCTION: Tumor microenvironment (TME) is a complex and heterogeneous network, consisting of stromal immune cells, embedded with cytokines, growth factors, soluble receptors, exosomes. Mutual dynamic crosstalk among cancer, cells predispose cancer to metastasis. Particularly, the main component breast TME represented by adipocytes, which secretory activity compromised in obesity. Indeed, hypertrophic, hyperplastic adipocytes undergo modified cytokines pattern, characterized...