A5024162586- S100 Proteins and Annexins
- Acute Ischemic Stroke Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Blood Pressure and Hypertension Studies
- Protease and Inhibitor Mechanisms
- Enzyme function and inhibition
- Cardiovascular Disease and Adiposity
- Thermoregulation and physiological responses
- Cholinesterase and Neurodegenerative Diseases
- Clinical Laboratory Practices and Quality Control
- Cardiovascular Health and Disease Prevention
- Venous Thromboembolism Diagnosis and Management
- Angiogenesis and VEGF in Cancer
- Drug-Induced Adverse Reactions
- Antioxidant Activity and Oxidative Stress
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Machine Learning in Bioinformatics
- Analytical Methods in Pharmaceuticals
- Nitric Oxide and Endothelin Effects
- Blood Coagulation and Thrombosis Mechanisms
- Intracerebral and Subarachnoid Hemorrhage Research
- Advanced Proteomics Techniques and Applications
- Chemical Reactions and Mechanisms
- Adipokines, Inflammation, and Metabolic Diseases
- Acute Myeloid Leukemia Research
Silesian Center for Heart Disease
2022
Wroclaw Medical University
2014-2020
(1) Background: The aim of this dynamic-LC/MS-human-serum-proteomic-study was to identify potential proteins-candidates for biomarkers acute ischemic stroke, their changes during phase stroke and define novel drug-targets. (2) Methods: A total 32 patients (29-80 years) with were enrolled the study. control group constituted 29 demographically-matched volunteers. Subjects presented clinical symptoms lasting no longer than 24 h, confirmed by neurological-examination and/or new cerebral...
(1) Objective: The aim of this dynamic LC-MS (liquid chromatography and mass spectrometry) human platelet proteomic study was to identify the potential proteins candidates for biomarkers acute ischemic stroke (AIS), their changes during phase define novel drug targets. (2) Methods: A total 32 patients (18-80 years old) were investigated that presented symptoms AIS lasting less than 24 h from onset, confirmed by neurological examination and/or new cerebral ischemia visualized in CT...
Thromboembolic events constitute a major health problem, despite the steadily expanding arsenal of antiplatelet drugs. Hence, there is still need to optimize therapy.The aim our study was verify hypothesis that are no differences in platelet proteome between two groups healthy people representing different acetylsalicylic acid (aspirin) responses as assessed by liquid chromatography/mass spectrometry (LC/MS) technique.A total 61 volunteers were recruited for study. Physical examination and...
Endothelial dysfunction is a common feature of early complications hemato-oncologic therapy. The aim our study was to assess the profile endothelial function at diagnosis time, then during initial treatment phase acute lymphoblastic leukemia (ALL), and verify presence its correlation with clinical outcome (ECO). 28 ALL children 18 healthy age-matched control ones were recruited. Study group examined baseline 33rd 78th day treatment. At each protocol step assessed by measurement sP-selectin...
Childhood acute lymphoblastic leukemia (ALL) survivors are at higher cardiovascular risk than the general population, which may result from anthracycline-related endothelial dysfunction (ED). However, a few studies indirectly show that ED appear in ALL children before treatment begins. Hence, this study we intended to verify hypothesis is part of phenotype.Twenty-eight and 14 healthy age-matched control were recruited. The group was examined baseline, then 33rd 78th day treatment. At each...
Objective: The aim of this study was to identify potential proteins-candidates for biomarkers and drug targets acute ischemic stroke. Design method: There were 32 patients at age 29–80 years with diagnosed stroke included into the group. control group constituted 30 volunteers demographically matched Patients enrolled on presented clinical symptoms lasting no longer than 24 hours, confirmed by trained neurologists examination or new brain ischemia visible in MR/CT (magnetic resonance imaging...
Objective: The aim of this study was to assess endothelial function profile in subjects with acute ischemic stroke. Design and method: There were 18 patients phase stroke enrolled study. Control group constituted n = 13 demographically-matched hospitalized because non-neurological diseases. Microvascular assessment performed by laser Doppler (Perimed, Järfälla, Sweden) at the first 24 hours from onset on seventh day start research. Measurements forearm cutaneous blood flow recorded baseline...
Objective: The aim of this study was to define the correlations between microvascular responsiveness and results basic biochemical laboratory tests. Design method: There were 19 patients in acute phase ischemic stroke enrolled study. Microvascular endothelial function assessment performed by laser Doppler (Perimed, Järfälla, Sweden) at first 24 hours from onset on seventh day beginning protocol. Measurements forearm cutaneous blood flow recorded baseline during exposure temperature 44°C....
Objective: Thrombo-embolic events are major health problem, despite the steadily-expanding arsenal of drugs inhibiting platelet function. Therefore, there is still a need to analyze function optimize anti-platelet therapy. The aim our study was verify hypothesis that no differences in proteome between two groups healthy people representing different acetylsalicylic acid (Aspirin, ASA) response using Liquid Chromatography/Mass Spectrometry - LC/MS technique. Design and method: A total 61...