A5008735299- CAR-T cell therapy research
- Viral Infectious Diseases and Gene Expression in Insects
- Biosimilars and Bioanalytical Methods
- Chromatin Remodeling and Cancer
- Immunotherapy and Immune Responses
- Central Venous Catheters and Hemodialysis
- Cancer Mechanisms and Therapy
- Virus-based gene therapy research
- Congenital Heart Disease Studies
- Pediatric Urology and Nephrology Studies
- Chemotherapy-induced cardiotoxicity and mitigation
- Acute Kidney Injury Research
- Diverse Music Education Insights
- Youth Development and Social Support
- Protein Degradation and Inhibitors
- Hemodynamic Monitoring and Therapy
- Occupational Therapy Practice and Research
- Mechanical Circulatory Support Devices
Texas Children's Hospital
2025
Baylor College of Medicine
2025
St. Jude Children's Research Hospital
2019-2024
University of Tennessee Health Science Center
2021-2022
Bromodomain-containing protein 9 (BRD9) is a recently identified subunit of SWI/SNF(BAF) chromatin remodeling complexes, yet its function poorly understood. Here, using genome-wide CRISPR-Cas9 screen, we show that BRD9 specific vulnerability in pediatric malignant rhabdoid tumors (RTs), which are driven by inactivation the SMARCB1 SWI/SNF. We find exists unique SWI/SNF sub-complex lacks SMARCB1, has been considered core subunit. While SMARCB1-containing complexes bound preferentially at...
ABSTRACT Background Immune effector cell (IEC) therapies, including chimeric antigen receptor (CAR)‐modified T‐cell therapy, have shown efficacy in pediatric B‐cell acute lymphoblastic leukemia (B‐ALL) and are being investigated for other malignancies. A common toxicity associated with IEC therapy is cytokine release syndrome (CRS), which can lead to cardiovascular decompensation due systemic inflammation. Data limited regarding adverse effects children. This study aims describe the effect...
The outcome for metastatic pediatric osteosarcoma (OS) remains poor. Thus, there is an urgent need to develop novel therapies, and immunotherapy with CAR T cells has the potential meet this challenge. However, a lack of preclinical models that mimic salient features human disease including reliable development post orthotopic OS cell injection. To overcome roadblock, also enable real-time imaging disease, we took advantage LM7 expressing firefly luciferase (LM7.ffLuc). LM7.ffLuc were...
Abstract Purpose: Clinical efficacy of chimeric antigen receptor (CAR) T cells against pediatric osteosarcoma (OS) has been limited. One strategy to improve may be drive chemokine-mediated homing CAR tumors. We sought determine the primary chemokines secreted by OS and evaluate B7-H3.CAR expressing cognate receptors. Experimental Design: developed a pipeline identify correlating RNA-seq data with chemokine protein detected in media from fresh surgical specimens. identified CXCR2 CXCR6 as...
<div>AbstractPurpose:<p>Clinical efficacy of chimeric antigen receptor (CAR) T cells against pediatric osteosarcoma (OS) has been limited. One strategy to improve may be drive chemokine-mediated homing CAR tumors. We sought determine the primary chemokines secreted by OS and evaluate B7-H3.CAR expressing cognate receptors.</p>Experimental Design:<p>We developed a pipeline identify correlating RNA-seq data with chemokine protein detected in media from fresh surgical...
<p>ELISA evaluation of IL8 and CXCL16 in models</p>
<p>Halo assay videos</p>
<p>CXCR transduced T cell data</p>
<p>Raw RNAseq data for chemokine ligand screen</p>
<p>CXCR.B7-H3.CAR Transduced T cell data</p>