A5062951882- Cancer Genomics and Diagnostics
- Renal and related cancers
- CAR-T cell therapy research
- Pancreatic and Hepatic Oncology Research
- Viral Infectious Diseases and Gene Expression in Insects
- Colorectal Cancer Surgical Treatments
- Neuroendocrine Tumor Research Advances
- Gastric Cancer Management and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Renal cell carcinoma treatment
- Chemical Reactions and Isotopes
- Gastrointestinal Tumor Research and Treatment
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Pancreatitis Pathology and Treatment
- Trauma and Emergency Care Studies
- Genetic and Kidney Cyst Diseases
- Abdominal Trauma and Injuries
- Biosimilars and Bioanalytical Methods
- Blood transfusion and management
- Social Media in Health Education
- Hepatocellular Carcinoma Treatment and Prognosis
- Radiomics and Machine Learning in Medical Imaging
- Cutaneous Melanoma Detection and Management
- Stoma care and complications
- Melanoma and MAPK Pathways
University of Tennessee Health Science Center
2018-2025
St. Jude Children's Research Hospital
2022-2024
University of Wales Trinity Saint David
2005-2024
University Hospital Lewisham
2010-2011
Columbus Oncology and Hematology Associates
2005
Royal College of Surgeons of England
1919
Can gene expression profiling be used to identify patients with T1-T2 melanoma at low risk for sentinel lymph node (SLN) positivity?Bioinformatics modeling determined a population in which 31-gene profile test predicted <5% SLN positivity. Multicenter, prospectively-tested (n = 1421) and retrospective 690) cohorts were validation outcomes, respectively.Patients 55-64 years ≥65 class 1A (low-risk) had positivity rates of 4.9% 1.6%. Class 2B (high-risk) 30.8% 11.9%. Melanoma-specific survival...
Abstract Developing synchronous bilateral Wilms tumor suggests an underlying (epi)genetic predisposition. Here, we evaluate this predisposition in 68 patients using whole exome or genome sequencing ( n = 85 tumors from 61 with matched germline blood DNA), RNA-seq 99 tumors), and DNA methylation analysis peripheral blood, 29 non-diseased kidney, tumors). We determine the predominant events for predisposition: 1)pre-zygotic genetic variants readily detectable [ WT1 (14.8%), NYNRIN (6.6%) ,...
Ileocecectomy (IC) as an alternative to right hemicolectomy (RH) for traumatic indication is controversial with limited comparison data. We sought compare IC vs RH injury and hypothesized there was no difference in outcomes. The Trauma Quality Improvement Program database queried from 2017 2022 patients evaluated using propensity score matching (PSM) a 1:3 ratio. Presenting factors outcomes were analyzed. After PSM, 558 186 had age, penetrating mechanism, time OR severity score. more likely...
THE citrate method" of blood transfusion has many technical advantages over any the other methods, and if, as is general opinion men who have had con- siderable experience different there no difference in results when citrated administered, then it probable that will completely displace others.The direat method from artery donor to vein recipient very drawbacks.In first place, its performance difficult, necessitates cutting down on both vessels insertion cannulas into each them.
Journal Article Trypanosomiasis in Southern Rhodesia Get access A. M. Fleming, C.M.G., M.B., F.R.C.S. (EDIN.), D.P.H. (CANTAB.) Medical Director Search for other works by this author on: Oxford Academic PubMed Google Scholar Transactions of The Royal Society Tropical Medicine and Hygiene, Volume 6, Issue 8, July 1913, Pages 298–310, https://doi.org/10.1016/S0035-9203(13)90209-1 Published: 01 1913
Abstract Purpose: Clinical efficacy of chimeric antigen receptor (CAR) T cells against pediatric osteosarcoma (OS) has been limited. One strategy to improve may be drive chemokine-mediated homing CAR tumors. We sought determine the primary chemokines secreted by OS and evaluate B7-H3.CAR expressing cognate receptors. Experimental Design: developed a pipeline identify correlating RNA-seq data with chemokine protein detected in media from fresh surgical specimens. identified CXCR2 CXCR6 as...
The story of the killing ‘last’ great auk (Pinguinus impennis) in Britain, apparently put to death as a witch at Stac an Armin St Kilda archipelago c. 1840, is well known. However, other accounts claim that was killed on main island, Hirta, having been condemned by celebrated men’s ‘parliament’. historical veracity three differing stories, which recount discreditable deeds deeply Christian community, evaluated; it seems fewest difficulties are raised if two auks were killed, one Hirta and...
Increased TERT mRNA is associated with disease relapse in favorable histology Wilms tumor (WT). This study sought to understand the mechanism of increased expression by determining association between and WT1 N-MYC, two proteins important pathogenesis that have been shown regulate expression. Three out 45 (6.7%) WTs corresponding patient-derived xenografts harbored canonical gain-of-function mutations promoter. identified near ubiquitous hypermethylation promoter region WT compared normal...
Abstract: Angiomatoid fibrous histiocytoma (AFH) is a relatively rare soft tissue tumor of intermediate malignant potential, occurring most commonly in young adults, with recognized propensity for local recurrence and occasional metastasis. A case AFH on the finger 60-year-old man described which unusual location age group this entity raised original wrong diagnosis an aneurysmal cellular histiocytoma. Further workup demonstrated EWSR1-CREB1 translocation, confirming correct AFH. Strong...
Patients with unstable cervical spine (C-spine) fractures are at a significant risk of respiratory failure. There is no consensus on the optimal timing tracheostomy in setting recent operative fixation (OCF). This study evaluated impact surgical site infections (SSIs) patients undergoing OCF and tracheostomy.Trauma Quality Improvement Program (TQIP) was used to identify isolated injuries who underwent between 2017 2019. Early (<7 days from OCF) compared delayed (≥7 OCF). Logistic regressions...