A5016762273- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Colorectal and Anal Carcinomas
- Breast Cancer Treatment Studies
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Screening and Detection
- Cervical Cancer and HPV Research
- Adrenal and Paraganglionic Tumors
- Hormonal Regulation and Hypertension
- Intraperitoneal and Appendiceal Malignancies
- Sarcoma Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Ovarian cancer diagnosis and treatment
- Management of metastatic bone disease
- Colorectal Cancer Surgical Treatments
- Cancer Diagnosis and Treatment
- Cutaneous Melanoma Detection and Management
- Ferroptosis and cancer prognosis
- Nonmelanoma Skin Cancer Studies
- Body Contouring and Surgery
- Vascular Tumors and Angiosarcomas
- Cancer Research and Treatments
- Breast Implant and Reconstruction
- PI3K/AKT/mTOR signaling in cancer
University of Tennessee Health Science Center
2019-2023
McMaster University
2015-2017
Chemotherapy Foundation
2017
St. Joseph’s Healthcare Hamilton
2016
University of Toronto
2010
University Health Network
2009
Dalhousie University
2009
London Health Sciences Centre
2009
Princess Margaret Cancer Centre
2009
Abstract Background Deficiencies in non-technical skills (NTS) have been increasingly implicated avoidable operating theatre errors. Accordingly, this study sought to characterize the impact of surgeon and anaesthetist on time crisis resolution a simulated theatre. Methods Non-technical were assessed during 26 crises (haemorrhage airway emergency) performed by surgical teams. Teams consisted surgeons, anaesthetists nurses. Behaviour was four trained raters using Non-Technical Skills for...
Abstract Background and Objectives Peritoneal metastases (PM) from primary colorectal cancer (pCRC) are associated with poor outcomes; however, molecular differences not well defined. Methods We compared unpaired tumor profiles of patients pCRC PM Caris Life Sciences. Testing included next‐generation sequencing 592 genes, microsatellite instability (MSI) mutational burden (TMB). Mutations were test‐defined as pathogenic (PATH). Results Six hundred seventeen 348 had similar gender (55% male)...
Background An implicit assumption in the analysis of colorectal readmission is that colon and rectal cancer patients are similar enough to analyze together. However, no studies have examined this whether substantial differences exist between patients. Methods This was a retrospective predictors, diagnoses, costs cohorts for 30‐day readmission. study included all aged >18 who received an elective colectomy or low anterior resection from April 2008 until March 2012 province Ontario. Results...
Abstract Background Adrenocortical carcinoma (ACC) is a rare tumor and the role of lymph node dissection remains ill‐defined. This study evaluates effect nodal examination on prognosis survival in patients undergoing curative‐intent resection ACC. Methods The National Cancer Database (2004‐2015) was queried for margin‐negative Patients with distant metastases, neoadjuvant therapy, multivisceral T4 tumors were excluded. Results Among 897 patients, 147 (16.4%) had nodes examined. Factors...
Socioeconomic disparities in gastric cancer have been associated with differences care and inferior outcomes. We evaluated the presentation, treatment, survival for patients (GC) a metropolitan setting large African American population.Retrospective cohort analysis of GC (2003-2018) across multi-hospital system was performed. Associations between socioeconomic clinicopathologic data were examined.Of 359 patients, 255 (71%) 104 (29%) Caucasian. Americans more likely to present at younger age...
498 Background: PM from CRC are associated with poor outcomes; however, molecular differences not defined. Methods: We compared tumor profiles of pCRC and patients (pts) Caris Life Sciences. Testing included next-generation sequencing (NGS) 592 genes, immunohistochemistry (IHC), copy number variants (CNV), microsatellite instability (MSI) mutational burden (TMB). Mutations were termed pathogenic (PATH) or undetermined significance (VUS). TMB in mutations/Mb (MMB) was compared. Results: 617...
5534 Background: Microsatellite instability (MSI+) and inactivation of the tumor suppressor gene PTEN are implicated in development endometrial cancer (EC). The aim this study was to compare prognostic value MSI 2 patient (pt) populations, early stage vs. advanced/recurrent disease. Methods: Archival paraffin embedded from pts with EC enrolled closed NCIC-CTG studies: I/II (EN5) disease(IND 126, 148 160) were examined for (BAT 25/26) expression (immunohistochemistry). status correlated...
Visceral angiosarcoma is rare and aggressive, accounting for 2% of soft tissue sarcomas. Using a national data set, we examine determinants outcomes patients presenting with this disease.The 2004-2015 National Cancer Database was queried visceral angiosarcoma. Trends in treatment were examined. Factors affecting overall survival (OS) assessed log-rank Cox regression.Eight hundred ninety-three identified (median age 65 years, male [63%], Charlson comorbidity index <1 [86%]). Tumor size <5 cm...
National studies have reported racial and socioeconomic disparities in gastric cancer (GC) care. The current study evaluated adequate lymph node (LN) assessment (≥16 LNs) during resection for GC within a healthcare system servicing socioeconomically disparate, mostly non-White population the Southeast United States.A retrospective cohort of patients undergoing between 2003-2019 was performed. Factors associated with LN including patient tumor characteristics were analyzed.Among 202 patients,...
Abstract Background and Objectives Published data comparing peritoneal metastases from appendiceal cancers (pAC) colorectal (pCRC) remain sparse. We compared pAC pCRC using comprehensive tumor profiling (CTP). Methods CTP was performed, including next‐generation sequencing analysis of copy number variation (CNV), microsatellite instability (MSI) mutational burden (TMB). Results One hundred thirty‐six 348 samples underwent CTP. The cohorts' age gender were similar. demonstrated increased...
Antecedentes: La introducción de la reparación endovascular los aneurismas (endovascular aneurysm repair, EVAR) ha reducido mortalidad perioperatoria cirugía aneurisma aorta abdominal (AAA).EL objetivo esta revisión sistemática fue valorar modelos predicción del riesgo existentes e identificar el más útil para pacientes sometidos a AAA tanto por EVAR como abierta (open surgical OSR).Métodos: Se llevó cabo una búsqueda literatura desde 2006 en con AAA.Se siguieron las guías PRISMA y se...
This chapter focuses on anal squamous cell carcinoma and its precursor lesions summarizes the relevant epidemiology, evaluation, management. Risk factors including human immunodeficiency virus status sexual practices as well role of papilloma in cancer pathogenesis are reviewed. Further understanding molecular biology will inform future strategies for targeted therapy, biomarkers such p16 p53 may emerge important prognostic indicators. Anal low-grade or high-grade intraepithelial lesion...
This chapter focuses on anal squamous cell carcinoma and its precursor lesions summarizes the relevant epidemiology, evaluation, management. Risk factors including human immunodeficiency virus status sexual practices as well role of papilloma in cancer pathogenesis are reviewed. Further understanding molecular biology will inform future strategies for targeted therapy, biomarkers such p16 p53 may emerge important prognostic indicators. Anal low-grade or high-grade intraepithelial lesion...