A5101639891- RNA modifications and cancer
- Photonic and Optical Devices
- Plant biochemistry and biosynthesis
- MicroRNA in disease regulation
- Advancements in PLL and VCO Technologies
- Chronic Kidney Disease and Diabetes
- Circular RNAs in diseases
- Semiconductor Lasers and Optical Devices
- GABA and Rice Research
- Metabolism, Diabetes, and Cancer
- Sirtuins and Resveratrol in Medicine
- Gestational Diabetes Research and Management
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- Renal Diseases and Glomerulopathies
- Plant Molecular Biology Research
- Cancer-related gene regulation
- Biochemical Acid Research Studies
- Epigenetics and DNA Methylation
- Natural Language Processing Techniques
- Antioxidants, Aging, Portulaca oleracea
- Immunodeficiency and Autoimmune Disorders
- Sugarcane Cultivation and Processing
- Peroxisome Proliferator-Activated Receptors
- HVDC Systems and Fault Protection
Fuzhou University
2025
Fujian Provincial Hospital
2025
Chinese Academy of Agricultural Sciences
2025
Chinese Academy of Sciences
2025
University of Chinese Academy of Sciences
2025
Beijing Normal University
2025
Institute of Microelectronics
2025
Leeds Arts University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2024
Chengdu University of Traditional Chinese Medicine
2024
Abstract Diabetic nephropathy (DN) is the major microvascular complication of diabetes mellitus and most important cause end‐stage renal disease worldwide. Metformin preferred oral hypoglycaemic drug for type 2 (T2DM). Recent studies have shown that besides lowering blood glucose, metformin also has protective effects on function, but its mechanism not clear. In this study, we established a diabetic rat model by high‐fat feeding combined with intraperitoneal injection streptozotocin. Their...
Abstract The efficacy and safety of self‐amplifying mRNA (saRNA) have been demonstrated in COVID‐19 vaccine applications. Unlike conventional non‐replicating (nrmRNA), saRNA offers a key advantage: its self‐replication mechanism fosters efficient expression the encoded protein, leading to substantial dose savings during administration. Consequently, there is growing interest further optimizing efficiency saRNA. In this study, vitro adaptive passaging conducted under exogenous interferon...
This paper presents a SerDes receiver for medium-reach interconnection in 28-nm CMOS process. It employs CTLE and an adaptive quarter-rate loop-unrolling 5-tap DFE utilizing SS-LMS algorithm to enable adjustment of tap coefficients under different channels. The proposed contains CML-based summer with CMFB technology two-stage dynamic comparator offset calibration loop. Simulation results show that this can operate at 25 Gb/s data rate power efficiency 5.99 pJ/bit, Its BER is less than 1E-12...
The C-repeat binding factor (CBF)/dehydration-responsive element (DREB1) belongs to a subfamily of the AP2/ERF (APETALA2/ethylene-responsive factor) superfamily, which can regulate many physiological and biochemical processes in plants, such as plant growth development, hormone signal transduction response abiotic stress. Although CBF/DREB1 family has been identified studies alfalfa are insufficient. In this study, 25 MsCBF genes were genome ("Zhongmu No. 4"). These distributed on...
Background Cervical lymph node metastasis (LNM) is a significant factor that leads to poor prognosis in laryngeal cancer. Early-stage supraglottic cancer (SGLC) prone LNM. However, research on risk factors for predicting cervical LNM early-stage SGLC limited. This study seeks create and validate predictive model through the application of machine learning (ML) algorithms. Methods The training set internal validation data were extracted from Surveillance, Epidemiology, End Results (SEER)...
This study explored the efficacy of large language models (LLMs), namely GPT-4, in supporting second (L2) writing comparison with interaction a human partner pre-writing phase. A within-subject behavioral experiment was conducted 23 Chinese L2 learners who were exposed to three conditions: “without interaction”, “interaction GPT-4”, and partner”. They then completed an task. It found that yielded significantly improved results compared both GPT-4 case without terms overall scores,...
Abstract Objectives Metformin (MET) has protective effect on diabetic nephropathy (DN). This study aims to demystify the mechanism of MET function in DN. Methods Mouse glomerular membrane epithelial cell line SV40-MES-13 was treated with normal or high glucose combined without MET. The relationships among H19, miR-143-3p and TGF-β1 were evaluated by luciferase reporter assay. MTT assay performed detect proliferation. levels inflammatory factors investigated enzyme-linked immunosorbent...
Objectives To evaluate the associations of urinary markers (eg albumin), glomerular transferrin [ TRF ], immunoglobulin G [IgG]), and tubular α1‐microglobulin [α1‐ MG β2‐microglobulin [β2‐ ]) with development diabetic kidney disease ( DKD ) in type 2 diabetes patients, as assessed by estimated filtration rate eGFR albuminuria. Material methods A total 252 patients 50 nondiabetic controls from Tianjin, China, were selected. Diabetic divided into three groups according to levels, including A,...
Abstract The aim of this study was to investigate the role metformin in high glucose‐induced mesangial cell proliferation, inflammation and extracellular matrix (ECM) accumulation elucidate underlying mechanism function. An MTT assay used examine rat (RMC) proliferation. levels TNF‐α, IL‐6 TGF‐β RMCs were determined by ELISA. protein expression fibronectin, collagen IV autophagy‐related proteins (Beclin‐1, LC3‐I LC3‐II) detected using western blot. Fluorescence microscopy analysis carried...
It is generally accepted that nuclear genes in eukaryotes are located independently on chromosomes and expressed a monocistronic manner. However, accumulating evidence suggests more complex landscape of gene structure transcription. Ganoderma lingzhi, model medicinal fungus, currently lacks high-quality genome annotation, hindering genetic studies.
Objective: This study aimed to investigate the mechanisms underlying Cd-induced urothelial transformation, using multi-omics analyses (transcriptome, epitranscriptome, and proteome).Methods: Transcriptomics analysis was performed estimate expression of genes, methylated RNA immunoprecipitation sequencing used detect m6A modification, while proteomics identify differentially expressed proteins. Differentially genes (DEGs) were subjected Gene Ontology Kyoto Encyclopedia Genes Genomes...
The aim of this study was to explore the possible influences age and gender on urinary Alpha 1-Microglobulin (α1-MG) concentrations establish specific reference values α1-MG in a group healthy adults.Two hundred ninety-nine adults (141 males 158 females) aged 20-60 were selected grouped by age. Urinary levels detected morning spot-urine samples, statistical analysis performed association between clinical parameters, differences groups compared. 95th percentile distribution used as normal...
To investigate the role of angiopoietin-2 (Ang-2) in tumor necrosis factor-α (TNF-α) induced apoptosis alveolar epithelium cells (AECs).TNF-α was used to induce human epithelial HPAEpiC cells, and Ang-2 siRNA vector transfected cells. RT-PCR Western blot were used. TUNEL staining applied observe apoptosis, annexin V-FITC-PI calculate rate.mRNA protein expressions Ang-2, activated Bax, cleaved caspase-3 up-regulated, but expression level Bcl-2 decreased (P < 0.05). After transfection siRNA,...