A5058590589- Acute Lymphoblastic Leukemia research
- Neuroblastoma Research and Treatments
- Acute Myeloid Leukemia Research
- Childhood Cancer Survivors' Quality of Life
- Iron Metabolism and Disorders
- Hemoglobinopathies and Related Disorders
- Blood disorders and treatments
- Neonatal Health and Biochemistry
- Chronic Myeloid Leukemia Treatments
- Glioma Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Lymphoma Diagnosis and Treatment
- Blood groups and transfusion
- COVID-19 and healthcare impacts
- Neutropenia and Cancer Infections
- COVID-19 Clinical Research Studies
- Ocular Oncology and Treatments
- Hematopoietic Stem Cell Transplantation
- Platelet Disorders and Treatments
- Immunodeficiency and Autoimmune Disorders
- Ethics and Legal Issues in Pediatric Healthcare
- Head and Neck Surgical Oncology
- Sarcoma Diagnosis and Treatment
- Folate and B Vitamins Research
- Testicular diseases and treatments
Post Graduate Institute of Medical Education and Research
2016-2025
University of Tennessee Health Science Center
2025
Methodist Le Bonheur Healthcare
2022-2025
Institute of Post Graduate Medical Education and Research
2013-2025
Delhi Pharmaceutical Science and Research University
2024
Joshi Hospital
2024
Sir Ganga Ram Hospital
2024
ASTER
2021
Dayanand Medical College & Hospital
2021
Institute of Cytology and Preventive Oncology
2021
Blastomycosis osteomyelitis is a well-known but infrequently encountered complication of infection with the dimorphic mold, Blastomyces dermatitidis. Oftentimes, diagnosis unsuspected, resulting in delay making diagnosis. The role intraoperative consultation rapid has not been discussed previously.Retrospective chart review clinicopathologic information was conducted from all cases blastomycosis and arthritis diagnosed at Rush University Medical Center between 2000 2010.Fourteen and/or were...
DEK::AFF2 squamous cell carcinoma is a recently recognized entity characterized by non-viral-related non-keratinizing with chromosomal rearrangement between DEK on 6p22.3 and AFF2 Xq28. This neoplasm associated an aggressive clinical behavior, particularly regarding local recurrences distant metastases even its deceptively bland histomorphology. In this article, we report 2 patients DEK:: carcinomas, which were only diagnosed at the time of recurrence. Patient #1 was originally misdiagnosed...
<title>Abstract</title> <bold>Purpose</bold> Postoperative complications can significantly impact patient outcomes and quality of life, particularly in children with solid tumors, as they may delay essential adjuvant therapy. This study aimed to evaluate the severity effects these validate Clavien–Dindo classification system pediatric patients following surgery for tumors. <bold>Methods</bold> A retrospective analysis was conducted on postoperative tumors at a tertiary care teaching hospital...
Abstract Background A lack of access to methotrexate levels is common in low‐ and middle‐income countries (LMIC), relevant for 80% children with cancer worldwide. We evaluated whether high‐dose (HD‐MTX) can be administered safely extended hydration leucovorin rescue, monitoring serum creatinine urine pH. Methods The prospective study was conducted at a single centre Chandigarh, India 2015. Patients B‐cell acute lymphoblastic leukemia (ALL) or T‐cell ALL non‐Hodgkin lymphoma (T‐NHL) were 3 5...
Considering conflicting data on CDKN2A/B deletion in ALL, this study to assess its prognostic significance as an independent marker a total of 96 pediatric B and T-ALL cases was planned. The overall frequency 44% (n = 43) with 36% (30/83) B-ALL 100% (13/13) T-ALL. significantly associated high WBC count (p .002) National Cancer Institute risk .01) B-ALL. Importantly, had poor EFS 42% at 28 months compared 90% rest .0004). Further, relapse free survival only 56% for deletions 25), control...
Viral infections are an underrecognized problem in children on standard chemotherapy for acute lymphoblastic leukemia (ALL). In countries with high baseline seroprevalence of cytomegalovirus (CMV) such as India, it may be important pathogen leading to fever, end-organ damage, and cytopenia. Data regarding the incidence manifestations CMV disease pediatric ALL patients scanty. The authors prospectively assessed all prolonged febrile neutropenia (FN) over a 3-year period. Children including...
Background: Aromatase deficiency is a rare autosomal recessive disorder caused by mutations in the CYP19A1 gene and characterized lack of conversion androgens to estrogens. It presents with virilization pregnant mothers during antenatal period, female fetuses at birth. Affected subjects either gender later manifest features estrogen androgen excess. Patient methods: We describe clinical course an Indian girl aromatase from birth 16 years age. Estrogen replacement was begun age 13.5 years....
Abstract Background The majority of patients in low‐ and middle‐income countries (LMIC) are unable to receive optimal therapy, including autologous stem cell transplant (ASCT) for high‐risk neuroblastoma. Management is intensive multidisciplinary; survival often poor. We report a single‐center outcome neuroblastoma, with adaptations optimized LMIC. Procedure study was retrospective. Patients were treated on the backbone neuroblastoma study‐1 SIOP‐Europe (HR‐NBL1/SIOPEN) protocol ASCT....
Abstract Cribriform adenocarcinoma of salivary gland (CASG) is a rare form neoplasm that mostly arises from minor glands. We report case CASG with high‐grade transformation harboring novel STRN3::PRKD1 fusion. A 59‐year‐old male presented palatal mass. Morphologically, the tumor consisted two components: solid and glandular low‐grade areas. The area comprised nests carcinoma central necrosis arranged in lobules delineated prominent stromal septa. cribriform microcystic architecture...
A child suffering from acute lymphoblastic leukemia on treatment with exclusive chemotherapy presented vision-threatening cytomegalovirus (CMV) retinitis in 1 eye. Prompt diagnosis and 3 weekly doses of 2 mg/0.1 mL intravitreal ganciclovir resulted successful healing CMV restoration visual acuity. In children without hematopoietic stem cell transplantation, has been reported only case literature. This was treated successfully intravenous ganciclovir. report highlights the use pediatric age...
Systematic screening identified patients with an iron refractory deficiency anaemia (IRIDA) phenotype and genotype in iron-deficient children the Indian subcontinent. Cases of moderate to severe microcytosis no obvious cause normal C-reactive protein, HbA2 tissue transglutaminase antibody levels (n = 550) were put on a trial oral for 4 weeks. Sixty these 550 cases (11%) variably therapy (<10 g/l Hb rise) at 4-6 weeks subsequently evaluated plasma iron, ferritin hepcidin levels. The mean age...
Acute lymphoblastic leukemia arising from lymphoid precursor cells of the bone marrow, lymphoreticular system, and soft tissue can present with medullary extramedullary involvement. Extramedullary involvement has propensity to affect a multitude organs. Presentation proptosis secondary orbital mass in childhood acute (ALL) is very rare. We report child pre-B cell ALL an involving both orbits presenting proptosis, give brief overview literature about this unusual entity. Rapid investigation...
Our clinics continued with approximately one-third of patients reporting for their appointments. Only who reside in the city and those staying temporarily during intensive phase therapy could attend. Patients from out attend hospital, as per lockdown rules, provided they had private transport (a bare few). We contacted our pediatrician colleagues neighboring cities states. Nearly half pediatricians were trained institute managed febrile neutropenia parenteral chemotherapy well given...
Abstract Background: Early detection is the key to contain ongoing pandemic. The current gold standard detect SARS CoV2 RT-PCR. However, it has a high false negative rate and long turnaround time. Purpose: In view of sensitivity CT in lower respiratory tract pathologies, study 2581 patients comparing RT-PCR status with findings was undertaken see if augments diagnostic performance. Materials Methods: A multi centre prospective consecutive cases conducted. All studies suggestive COVID 19...
Copy number alteration (CNA) status and CNA risk profiles of IKZF1plus , UK-ALL groups MRplus scores, were evaluated for clinical prognostic impact in a cohort 493 B-cell acute lymphoblastic leukemia cases diagnosed treated under the Indian Collaborative Childhood Leukemia group (ICiCLe) protocol trial. Overall frequency was 59% with 60% showing 2-loci deletion. CDKN2A/B deletion most common (36.3%), while IKZF1 profile noted 19.5% 13.4% cases, respectively. deletions other significantly...
ABVD regimen for Hodgkin lymphoma (HL) is frequently used in children and young adults low-middle income countries (LMIC). The feasibility safety data 'non-ABVD' protocols from LMIC limited. retrospective study was conducted a single center India. Euronet PHL-C1 based protocol administered during 2010-19. A PET-CT performed at diagnosis following two OEPA cycles. Radiotherapy inadequate PET response. During the 10-year period, 143 patients with HL were treated. mean age 7.8 ± 2.5 years....