A5101662539- Microfluidic and Bio-sensing Technologies
- Microfluidic and Capillary Electrophoresis Applications
- Electrowetting and Microfluidic Technologies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Electrohydrodynamics and Fluid Dynamics
- Advanced Sensor and Energy Harvesting Materials
- Micro and Nano Robotics
- Bacteriophages and microbial interactions
- Biosensors and Analytical Detection
- Modular Robots and Swarm Intelligence
- Nanopore and Nanochannel Transport Studies
- Tactile and Sensory Interactions
- Viral gastroenteritis research and epidemiology
- Neuroscience and Neural Engineering
- Electrical and Bioimpedance Tomography
- Pickering emulsions and particle stabilization
- 3D Printing in Biomedical Research
- Advanced biosensing and bioanalysis techniques
- Energy, Environment, Economic Growth
- Virus-based gene therapy research
- Gold and Silver Nanoparticles Synthesis and Applications
- Advanced Biosensing Techniques and Applications
- CRISPR and Genetic Engineering
- Climate Change Policy and Economics
- Evolution and Genetic Dynamics
Harbin Institute of Technology
2015-2024
Shanghai Ninth People's Hospital
2024
Shanghai Jiao Tong University
2024
State Key Laboratory of Robotics and Systems
2018-2024
Harvard University
2015-2024
Macau University of Science and Technology
2024
Nanchang Hangkong University
2024
Harbin University
2015-2021
National Institutes of Health
2021
Harvard University Press
2014-2015
Chronic wounds have become a significant threat to people's physical and mental health increased the burden of social medical care. Intelligent wound dressing (IWD) with condition monitoring closed-loop on-demand drug therapy can shorten healing process alleviate patient suffering. However, single-function dressings cannot meet current needs chronic treatment. Here, wearable IWD consisting exudate management, sensor monitoring, therapy, flexible circuit modules is reported, which achieve...
Microfluidic systems have been developed widely in scaled-down processes of laboratory techniques, but they are usually limited achieving stand-alone functionalities. It is highly desirable to exploit an integrated microfluidic device with multiple capabilities such as cell separation, single-cell trapping, and manipulation. Herein, we reported a platform actuation electrodes, for separating cells microbeads, bipolar rotating, propelling single microbeads. The separation microbeads can be...
The interfacial tension gradient forms tangential stress that drives fluid flow at a liquid–liquid interface, known as the Marangoni convection. In this study, we report on electrocapillary-driven polarizable interface between gallium-based liquid metal droplet (LMD) and electrolytes, activated by rotating electric field. When field frequency exceeds 50 Hz, amplitude of oscillatory movement LMD decays to zero, resulting in stationary droplet. Utilizing micrometer-resolution particle image...
Position-controllable trapping of particles on the surface a bipolar metal strip by induced-charge electroosmotic (ICEO) flow is presented herein. We demonstrate nonlinear ICEO slip profile electrode accounting for stable particle behaviors above double-layer relaxation frequency, while no occurs in DC limit as result strong upward fluidic drag induced linear profile. By extending an AC-flow field effect transistor from to AC field, we reveal that fixed-potential exceeding RC charging...
Continuous dielectrophoretic separation is recognized as a powerful technique for large number of applications including early stage cancer diagnosis, water quality analysis, and stem-cell-based therapy. Generally, the prefocusing particle mixture into stream an essential process to ensure all particles are subjected same electric field geometry in region. However, accomplishing this focusing either requires hydrodynamic squeezing, which encumbering peripheral system complicated operation...
Induced-charge electroosmosis (ICEO) phenomena have been attracting considerable attention as a means for pumping and mixing in microfluidic systems with the advantage of simple structures low-energy consumption.
We report a unique phenomenon in which liquid metal droplets (LMDs) under pure ac electric field pump fluid. Unlike the directional pumping that occurs upon reversing polarity dc signal, this allows direction of fluid motion to be switched by simply shifting position LMD within cylindrical chamber. The physical mechanism behind has been termed Marangoni flow, caused nonlinear electrocapillary stress. Under influence localized, asymmetric field, polarizable surface position-offset produces...
We developed a rapid, targeted and culture-free infectivity assay using high-throughput drop-based microfluidics. The high sensitivity large dynamic range of our cost effective alleviates the need for serial dilution experiments.
Herein we describe a novel AC electrothermal (ACET) fluidic circulatory pumping chip to overcome the challenge of fluid-to-tissue ratio for "human-on-a-chip" cell culture systems. To avoid deleterious effects Joule heating and electric current on sample cells, rectangular microchannel was designed with distantly separated regions culture. Temperature variations were examined using commercial thermocouple sensor detect temperature values in both regions. generate sufficient ACET rate, 30...
Viral evolutionary pathways are determined by the fitness landscape, which maps viral genotype to fitness. However, a quantitative description of landscape and forces on it remain elusive. Here, we apply biophysical model based capsid folding stability antibody binding affinity predict pathway norovirus escaping neutralizing antibody. The is validated experimental evolution in bulk culture drop-based microfluidics that propagates millions independent small subpopulations. We demonstrate...
We utilize electric fields to trigger the on-demand release of different cargos that are encapsulated in water-in-oil-in-water (W/O/W) double-emulsion droplets.
We propose a novel continuous-flow microfluidic particle concentrator with specified focusing-particle number ratio (FR) at different channel outlets using induced-charge electroosmosis (ICEO).
We propose a simple, inexpensive microfluidic chip for large-scale trapping of single particles and cells based on induced-charge electroosmosis in rotating electric field (ROT-ICEO). A central floating electrode array, was placed the center gap between four driving electrodes with quadrature configuration used to immobilize or cells. Cells were trapped array by interaction ROT-ICEO flow buoyancy flow. experimentally optimized efficiency investigating important parameters like particle cell...
We propose a simplified multifunctional traffic control approach that effectively combines dielectrophoresis (DEP) and alternating current electrothermal (ACET) flow to realize continuous particle trapping, switching, sorting. In the designed microsystem, combined DEP ACET effects, which are symmetrically generated above bipolar electrode surface, contribute focus incoming colloidal particles into thin beam. Once is energized with an electric gate signal completely in phase driving (AC)...
We propose herein to make use of rotating electric fields for achieving flexible control on the hydrodynamic behavior two miscible co-flowing water solutions in straight microchannels, context a new manipulation tool stratified liquid contents microfluidic systems. Our theoretical analysis indicates that, while fluids distinct electrical conductivities and identical permittivity are parallel pumped into mainchannel, circularly traveling field, as emitted from four-phase electrode array...
Based on the continuum mechanics theory, we propose herein a universal design of microfluidic ionic diode based external concentration polarization gating ion-selective medium embedded in network with four power terminals. This micro/nanofluidic hybrid chip employs cation-exchange nanoporous membrane (CEM) coupled both control and output channel. Under action vertical electric field throughout CEM, nanoscale surface conduction excessive counterions within charged nanopores is converted to...
Herein, we first describe a perfusion chip integrated with an AC electrothermal (ACET) micromixer to supply uniform drug concentration tumor cells. The in-plane fluid microvortices for mixing were generated by six pairs of reconstructed novel ACET asymmetric electrodes. To enhance the efficiency, electrodes rotating angles 0°, 30°, and 60° investigated. angle exhibited highest efficiency both simulated experimental results. length area is 7 mm, 89.12% (approximate complete mixing) at voltage...
We utilize an ac electric field to trigger the on-demand fusion of two aqueous cores inside water-in-oil-in-water (W/O/W) double-emulsion drops.
Induced-charge electroosmosis has attracted lots of attention from the microfluidic community over past decade. Most previous researches on this subject focused induced-charge (ICEO) vortex streaming actuated ideally polarizable surfaces immersed in electrolyte solutions. Starting point, we conduct herein a linear asymptotic analysis nonlinear electroosmotic flow next to leaky dielectric blocks arbitrary electrical conductivity and permittivity harmonic AC electric fields, theoretically...
In this study, we proposed a high-throughput separation strategy of the binary colloid mixture by dielectrophoresis (DEP) induced around large-scale bipolar electrode arrays embedded in microfabricated fluidic networks via thorough numerical investigation. The usage floating (FE) eliminates need external Ohmic connection to individual array units, therefore potentially steering faddish design new microdevice structures. Diffuse charge dynamics within double layer at opposite ends every FE...
ABSTRACT Human noroviruses (HuNoVs) are positive-sense RNA viruses that can cause severe, highly infectious gastroenteritis. HuNoV outbreaks frequently associated with recombination between circulating strains. Strain genotyping and phylogenetic analyses show often recombine in a conserved region near the junction of viral polyprotein (open reading frame 1 [ORF1]) capsid (ORF2) genes occasionally within RNA-dependent polymerase (RdRP) gene. Although methods useful for tracking changes...
By imposing a biased gate voltage to center metal strip, arbitrary symmetry breaking in induced-charge electroosmotic flow occurs on the surface of this planar electrode, phenomenon termed as AC-flow field effect transistor (AC-FFET). In work, potential AC-FFET with shiftable stagnation line flexibly manipulate micro-nano particle samples both static and continuous condition is demonstrated via theoretical analysis experimental validation. The finite Debye length induced double-layer applied...
Abstract The phenomenon of electrothermal (ET) convection has recently captured great attention for transporting fluidic samples in microchannels embedding simple electrode structures. In the classical model ET‐induced flow, a conductivity gradient buffer medium is supposed to arise from temperature‐dependent electrophoretic mobility ionic species under uniform salt concentrations, so it may not work well presence evident concentration perturbation within background electrolyte. To solve...