A5031382747- Genetics, Aging, and Longevity in Model Organisms
- Axon Guidance and Neuronal Signaling
- FOXO transcription factor regulation
- Genetics and Neurodevelopmental Disorders
- CRISPR and Genetic Engineering
- Neurogenesis and neuroplasticity mechanisms
- Epigenetics and DNA Methylation
- ATP Synthase and ATPases Research
- Selenium in Biological Systems
- Protein Kinase Regulation and GTPase Signaling
- GDF15 and Related Biomarkers
- Reproductive Biology and Fertility
- Glycosylation and Glycoproteins Research
- Proteoglycans and glycosaminoglycans research
- Circadian rhythm and melatonin
- Birth, Development, and Health
- Retinal Development and Disorders
University of Copenhagen
2014-2023
Monash University
2016-2019
Aarhus University
2012-2013
Significance Animals constantly monitor their internal energy levels and modify eating foraging behavior as required. Our work defines a role for the ETS-5 transcription factor in control of body fat thereby activity animals. We have defined responses controlled by at genetic, cellular, organismal identified how interacts with known pathways that regulate food-regulated behavioral states. These findings provide insight into are regulated satiety controls activity.
Summary NDG ‐4 is a predicted transmembrane acyltransferase protein that acts in the distribution of lipophilic factors. Consequently, ndg‐4 mutants lay eggs with pale appearance due to lack yolk, and they are resistant sterility caused by dietary supplementation long‐chain omega‐6 polyunsaturated fatty acid dihommogamma‐linolenic ( DGLA ). Two other proteins, NRF ‐5 ‐6, homolog mammalian secreted lipid binding homolog, respectively, have previously been shown function same transport...
Post-translational histone modifications regulate chromatin compaction and gene expression to control many aspects of development. Mutations in genes encoding regulators H3K4 methylation are causally associated with neurodevelopmental disorders characterized by intellectual disability deficits motor functions. However, it remains unclear how influences nervous system development contributes the aetiology disease. Here, we show that catalytic activity set-2, Caenorhabditis elegans homologue...
Rac GTPases act as master switches to coordinate multiple interweaved signaling pathways. A major function for is control neurite development by influencing downstream effector molecules and In Caenorhabditis elegans, the proteins CED-10, RAC-2 MIG-2 in parallel axon outgrowth guidance. Here, we have identified a single glycine residue CED-10/Rac1 Switch 1 region that confers non-redundant but not Mutation of this glutamic acid (G30E) reduces GTP binding inhibits does affect other canonical...
Nogo-A is a membrane-bound protein that functions to inhibit neuronal migration, adhesion, and neurite outgrowth during development. In the mature nervous system, stabilizes wiring plasticity regeneration after injury. Here, we show RET-1, sole homolog in Caenorhabditis elegans, required control developmental of specific subset neurons. ret-1 deletion mutant animals, ventral nerve cord axons are misguided where they fail respect midline boundary. We found expressed multiple neurons...
Understanding fundamental mechanisms governing axon outgrowth and guidance can inform the development of therapeutic strategies to restore neuronal function damaged though injury or disease. Axons navigate extracellular environment by responding cues that bind cell surface receptors relay information intracellularly via Rho GTPase family members, including Rac GTPases. GTPases act as master switches regulate diverse signalling pathways control actin cytoskeleton-a major driver outgrowth....
Epigenetic marks and associated traits can be transmitted for one or more generations, phenomena known respectively as inter- transgenerational epigenetic inheritance. It remains unknown if genetically conditionally induced aberrant states influence the development of nervous system across generations. Here, we show, using Caenorhabditis elegans a model system, that alteration H3K4me3 levels in parental generation, caused by genetic manipulation changes conditions, has, respectively, trans-...
ABSTRACT Rac GTPases act as master switches to coordinate multiple interweaved signaling pathways. A major function for is control neurite development by influencing downstream effector molecules and In Caenorhabditis elegans , the proteins CED-10, RAC-2 MIG-2 in parallel axon outgrowth guidance. Here, we have identified a single glycine residue CED-10/Rac1 Switch 1 region that confers non-redundant but not Mutation of this glutamic acid (G30E) reduces GTP binding inhibits does affect other...