A5061562078- Cell Adhesion Molecules Research
- Microbial metabolism and enzyme function
- Cellular Mechanics and Interactions
- Cancer, Hypoxia, and Metabolism
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Medical Imaging and Pathology Studies
- Cancer Genomics and Diagnostics
- HER2/EGFR in Cancer Research
- Heme Oxygenase-1 and Carbon Monoxide
- Chemotherapy-induced cardiotoxicity and mitigation
- 3D Printing in Biomedical Research
- Angiogenesis and VEGF in Cancer
- Cancer Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- NF-κB Signaling Pathways
- Cancer Mechanisms and Therapy
- Cancer Treatment and Pharmacology
- PI3K/AKT/mTOR signaling in cancer
- Axon Guidance and Neuronal Signaling
- Neurogenesis and neuroplasticity mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Genetics, Aging, and Longevity in Model Organisms
- Peptidase Inhibition and Analysis
University of Copenhagen
2009-2024
Abstract A desmoplastic colorectal cancer stroma, characterized by excess turnover of the cancer-associated fibroblast derived collagens type III and VI, can lead to reduced drug-uptake poor treatment response. We investigated association between biomarkers collagen VI overall survival (OS) in patients with metastatic (mCRC). Serum samples were collected from 252 mCRC prior bevacizumab chemotherapy. concentrations reflecting formation (PRO-C3) (PRO-C6) degradation (C6M C6Mα3) determined...
// Anette M. Høye 1, * , Sofie D. Tolstrup Edward R. Horton 1 Monica Nicolau Helen Frost Jung H. Woo 2 Jeremy P. Mauldin Arthur E. Frankel 3 Thomas Cox 4 and Janine T. Erler Biotech Research Innovation Centre (BRIC), Faculty of Health Medical Sciences, University Copenhagen (UCPH), Copenhagen, Denmark Baylor Scott White Health, Temple, TX, USA South Alabama Mitchell Cancer Institute, Mobile, AL, The Garvan Institute Kinghorn Centre, Division, St Vincent's Clinical School, Medicine, UNSW,...
Abstract Integrins, a family of heterodimeric adhesion receptors are implicated in cell migration, development and cancer progression. They can adopt conformations that reflect their activation states thereby impact strength migration. Integrins an intermediate state may be optimal for migration we have shown previously fully activated integrin α9β1 corresponds with less migratory behaviour melanoma cells. Here, aimed to identify components associated the status α9β1. Using lines naturally...
3588 Background: The local microenvironment of a tumor plays an important role in colorectal cancer (CRC) progression. A desmoplastic stroma surrounding the tumor, characterized by excessive collagen deposition, can result reduced drug delivery into leading to poor prognosis and lack therapy response. Here we present new class liquid biopsy proteins, reflecting formation (desmoplasia) evaluate their prognostic use CRC. Methods: Pro-peptides from type III (PRO-C3) VI (PRO-C6) were measured...
Nogo-A is a membrane-bound protein that functions to inhibit neuronal migration, adhesion, and neurite outgrowth during development. In the mature nervous system, stabilizes wiring plasticity regeneration after injury. Here, we show RET-1, sole homolog in Caenorhabditis elegans, required control developmental of specific subset neurons. ret-1 deletion mutant animals, ventral nerve cord axons are misguided where they fail respect midline boundary. We found expressed multiple neurons...
Abstract Background Glioblastoma is a highly aggressive brain cancer and, unlike many other cancers types, the median survival for patients after treatment (14.6 months) has barely improved in last 20 years. Infiltrative growth into surrounding parenchyma facilitates tumor recurrence and ultimately death of patient - novel therapies targeting this process are desperately needed. Lysyl oxidase inhibition been shown to decrease invasive variety solid tumours potential therapy glioblastoma...
Abstract Tumor Endothelial Marker 8 (TEM8) is an integrin-like cell-surface receptor originally identified being specific to tumor endothelial cells in colorectal cancer (CRC) blood vessels. Further investigation showed upregulated TEM8 expression vessels of various types, as well certain cells. We observe increase metastatic cell lines compared their non-metastatic counterpart both colon and breast lines. In order investigate whether required for growth metastasis we have developed a...