A5085623292- Antibiotic Resistance in Bacteria
- Antifungal resistance and susceptibility
- Bacterial Identification and Susceptibility Testing
- Bacterial biofilms and quorum sensing
- Antimicrobial Resistance in Staphylococcus
- COVID-19 Clinical Research Studies
- Pharmaceutical and Antibiotic Environmental Impacts
- Vibrio bacteria research studies
- SARS-CoV-2 and COVID-19 Research
- Antibiotics Pharmacokinetics and Efficacy
- Helicobacter pylori-related gastroenterology studies
- COVID-19 diagnosis using AI
- Probiotics and Fermented Foods
- Streptococcal Infections and Treatments
- Infections and bacterial resistance
- Salmonella and Campylobacter epidemiology
- Enterobacteriaceae and Cronobacter Research
- Microscopic Colitis
- Clostridium difficile and Clostridium perfringens research
- Surgical site infection prevention
- Sepsis Diagnosis and Treatment
- Antimicrobial Peptides and Activities
- Fungal Infections and Studies
- Listeria monocytogenes in Food Safety
- Urinary Tract Infections Management
Imam Abdulrahman Bin Faisal University
2016-2025
King Fahd Hospital of the University
2022
King Fahad Specialist Hospital
2018
Alexandria University
2018
University of Tennessee at Knoxville
2018
The molecular epidemiology and mechanisms of resistance carbapenem-resistant Enterobacteriaceae (CRE) were determined in hospitals the countries Gulf Cooperation Council (GCC), namely, Saudi Arabia, United Arab Emirates, Oman, Qatar, Bahrain, Kuwait. Isolates subjected to PCR-based detection antibiotic-resistant genes repetitive sequence-based PCR (rep-PCR) assessments clonality. Sixty-two isolates which screened positive for potential carbapenemase production assessed, 45 found produce...
The molecular epidemiology and mechanisms of resistance carbapenem-resistant Acinetobacter baumannii (CRAB) were determined in hospitals the states Cooperation Council for Arab States Gulf (Gulf [GCC]), namely, Saudi Arabia, United Emirates, Oman, Qatar, Bahrain, Kuwait. Isolates subjected to PCR-based detection antibiotic genes repetitive sequence-based PCR (rep-PCR) assessments clonality. Selected isolates multilocus sequence typing (MLST). We investigated 117 resistant carbapenem...
Candida auris is a globally-emerging pathogen that correlated to nosocomial infections and high mortality rates, causing major outbreaks in hospitals serious public health concerns worldwide. This study investigated the antifungal activity of silver nanoparticles (AgNPs) on clinical isolates C. auris. A total eight were collected from blood, urine, ear swab, groin. was confirmed by MALDI-TOF MS, gene sequencing. All as subjected antimicrobial agents, including amphotericin B, fluconazole,...
Carbapenem-resistant Acinetobacter baumannii is a major health problem worldwide, especially in intensive care units (ICUs). This study aimed to detect the prevalence of A. colonization gastrointestinal tract patients admitted ICU two hospitals Saudi Arabia. In addition, it characterize molecular mechanisms carbapenem resistance these isolates. From January June 2014, 565 rectal swab specimens were screened for Acinetobacer strains and using CHROMagar KPC agar plates, respectively. Organism...
Non-O1, non-O139 Vibrio cholerae (NOVC) extraintestinal infections are rare, but recently, several clinical incidents have been reported worldwide. Toxigenic V. is a well-known etiological agent of cholera, responsible for acute dehydrating watery diarrhea. Outbreaks occur in an epidemic seasonal pattern, particularly countries with poverty and poor sanitation. Strains NOVC usually not involved causing the or pandemic outbreaks seen potential strains serogroup O1 O139. However, they can...
Clostridium perfringens is a spore-forming, Gram-positive anaerobic pathogen that causes several disorders in humans and animals. A multidrug-resistant strain was isolated from the fecal sample of patient who clinically suspected gastrointestinal infection had recent history antibiotic exposure diarrhea. The identified by 16s rRNA sequencing as perfringens. strain's pathogenesis analyzed through its complete genome, specifically antimicrobial resistance-related genes. IRMC2505A genome...
Enterococcus avium (E. avium) is a Gram-positive nosocomial pathogen that commonly isolated from the alimentary tract. The objective of this functional genomics study was to identify resistant genes by analyzing genome E. IRMC1622a, type bacteria found in feces collected patient at Saudi Arabian tertiary hospital. bacterial strain IRMC1622a identified 16 S rRNA sequencing as sp. resistance phenomics were performed using VITEK® 2, and morphological analysis achieved scanning electron...
Chryseobacterium gleum is commonly distributed in the environment. It can cause a wide variety of infections immunocompromised patients hospital setting.A 6 month old infant with nephrotic syndrome was admitted to emergency room for an acute onset fever, difficulty breathing, cyanosis, and low oral intake. Cultures endotracheal tube specimens were positive which confirmed by ribosomal sequencing. The organism susceptible trimethoprim-sulfamethoxazole, minocycline, levofloxacin. patient...
Carbapenem-resistant Enterobacteriaceae (CRE) and carbapenem-resistant Pseudomonas aeruginosa (CRPAE) are globally a major medical issue, especially in intensive care units. The digestive tract is the main reservoir for these isolates; therefore, rectal swab surveillance highly recommended. purpose of this study was to detect prevalence gastrointestinal colonization CRE CRPAE patients admitted units Saudi Arabia. This project also aimed characterize carbapenem-hydrolyzing enzyme production...
Modifying cotton fabrics to obtain significant new properties is of relevance creating multifunctional textiles that could address challenges across different sectors. One the critical associated with hospital-acquired infections, which be prevented through utilization antimicrobial fabrics. Titanium dioxide (TiO 2 ) nanoparticles (NPs) have been introduced in literature for their photocatalytic antibacterial applications against prevalent microorganisms, such as Escherichia coli and...
Nontyphoidal Salmonella (NTS) species are important food-borne pathogens that cause gastroenteritis and bacteremia, responsible for a huge global burden of morbidity mortality. The aim this study was to investigate the prevalent serogroups antibiotic resistance NTS in our region.
Candida auris is an emerging multi-drug resistant pathogen with high mortality rate; nosocomial infections have been reported worldwide, causing a major challenge for clinicians and microbiological laboratories. The study aims to describe new cases of C. detect drug resistance-associated mutations by the sequencing ERG11 FKS1 genes. A total six specimens were collected from blood, urine, ear swab, groin screening samples. Isolates incubated 48 h on Sabouraud Dextrose agar (SDA) at 42 °C,...
Extensive drug resistance to bacterial infections in hospitalised patients is accompanied by high morbidity and mortality rates due limited treatment options. This study investigated the clinical outcomes of single combined antibiotic therapies extensive (XDR), multidrug-resistant (MDR) susceptible strains (SS) hospital-acquired (HAIs). Cases hospital-associated drug-resistant (HADRIs) a few from hospital wards were selected for this study. Bacteria identifications (IDs) antimicrobial...
Antimicrobial resistance (AMR) of non-fermenting Gram-negative bacteria (NFGNB) is increasingly recognized as urgent healthcare threat. Trend data on AMR NFGNB in Saudi Arabia are either old or limited. The objective was to estimate the prevalence and trends isolated Arabia.A retrospective multicenter study involving seven tertiary care hospitals conducted between 2011 2016. Susceptibility testing for non-duplicate isolates performed according Clinical Laboratory Standards Institute (CLSI)...
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Purpose. Enterobacteriaceae encoding plasmid-mediated AmpC (pAmpC) β-lactamases confer resistance to the third generation cephalosporins. pAmpC association with extended spectrum (ESBLs), quinolone (PMQR) and aminoglycoside modifying enzymes (AMEs) is well documented. There are limited data regarding epidemiology clinical significance of in Saudi Arabia. This study aimed determine prevalence its coexistence ESBLs, PMQR AMEs Escherichia coli, Klebsiella pneumoniae Proteus mirabilis isolates...
The rapid increase in coronavirus disease 2019 (COVID-19) cases during the subsequent waves Saudi Arabia and other countries prompted Critical Care Society (SCCS) to put together a panel of experts issue evidence-based recommendations for management COVID-19 intensive care unit (ICU).The SCCS included 51 with expertise critical care, respirology, infectious disease, epidemiology, emergency medicine, clinical pharmacy, nursing, respiratory therapy, methodology, health policy. All members...
There is a global health concern associated with the emergence of multidrug-resistant (MDR) fungus Candida auris, which has significant mortality rates. Finding innovative and distinctive anti-Candida compounds essential for treating infections caused by MDR C. auris. A bacterial strain activity was isolated identified using 16 S rRNA gene sequencing. The whole genome sequenced to identify biosynthesis-related clusters. pathogenicity cytotoxicity isolate were analyzed in HFF-1 cell lines,...
BACKGROUND: Klebsiella ozaenae ( K . ), a forgotten pathogen that normally colonizes the upper respiratory mucosa, can be associated with severe and invasive infections. The objectives of this study were to determine frequency isolation at microbiology laboratory in tertiary hospital scope diseases it characterize its antimicrobial susceptibility pattern. MATERIALS AND METHODS: This cross-sectional analyzed retrospective data, from 2002 2021, on cases laboratory-confirmed care hospital....
Novel antifungal drugs are urgently needed to treat candidiasis caused by the emerging fungal multidrug-resistant pathogen Candida auris. In this study, most cost-effective drug repurposing technology was adopted identify an appropriate option among 1615 clinically approved with anti-C. auris activity. High-throughput virtual screening of 1,3-beta-glucanosyltransferase inhibitors conducted, followed analysis stability complexes and 1,3-beta-glucanosyltransferase–dutasteride metabolite...
Multiple studies worldwide have reported the clinical and epidemiological features of coronavirus disease 2019 (COVID-19), with limited reports from Middle East. This study describes COVID-19 cases in Eastern Province Saudi Arabia identified factors associated severity illness.This was an observational 341 cases. These were first three months after case country identified. Clinical demographic data analyzed described to identify effects age, sex, ethnicity on illness severity. In addition,...
The emergence of multidrug-resistant fungi Candida auris is a worldwide health crisis connected with high rates mortality. There critical need to find novel and unique antifungal compounds for treating infections such as C. auris. This study aimed illustrate that biosynthetic gene clusters in native bacterial isolates are able produce against the fungus It was successfully achieved using large-scale activity screening, cytotoxicity analysis, whole genome sequencing integrated mining-guided...
Abstract Background There is inconsistent evidence about the association between Helicobacter pylori ( H. ) and dental diseases with possible effect of environmental factors. The aims study were to assess (1) gastric oral colonization (2) diseases. Methods A cross‐sectional was conducted in King Fahad University hospital Khobar, Eastern Saudi Arabia 2017. Patients admitted Endoscopy Unit recruited clinically examined for plaque, decayed teeth (D), filled (F), missing (M), periodontal pocket...
Abstract The biocompatible hybrid Zeolitic imidazolate framework-8 (ZIF-8)/structured silica nanocomposite can be loaded with antioxidants such as curcumin and resveratrol to offer multiple advantages of drug functionalization structural stability. blastocystosis, an enteric parasite, has various outcomes its treatment includes drugs which have side effects do not result in a full cure. We aimed design novel nanocomposites containing natural antioxidant, or ZIF-8/mesoporous silica. also...