A5101725171- Orthopedic Infections and Treatments
- Bone fractures and treatments
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Antimicrobial Resistance in Staphylococcus
- Cancer Immunotherapy and Biomarkers
- Osteomyelitis and Bone Disorders Research
- Scoliosis diagnosis and treatment
- Cancer Mechanisms and Therapy
- Orthopedic Surgery and Rehabilitation
- Orthopaedic implants and arthroplasty
- Anorectal Disease Treatments and Outcomes
- Advanced biosensing and bioanalysis techniques
- Reconstructive Surgery and Microvascular Techniques
- Colorectal Cancer Surgical Treatments
- Medical Imaging and Analysis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal Cancer Treatments and Studies
- Retinal Imaging and Analysis
- Bacterial biofilms and quorum sensing
- Musculoskeletal synovial abnormalities and treatments
- bioluminescence and chemiluminescence research
- Tea Polyphenols and Effects
- Total Knee Arthroplasty Outcomes
- Head and Neck Surgical Oncology
81th Hospital of PLA
2025
Southern Medical University
2015-2024
Zhujiang Hospital
2021-2024
Qingdao University
2023-2024
Affiliated Hospital of Qingdao University
2023-2024
Huazhong University of Science and Technology
2024
Shandong Normal University
2023
Xiamen University
2023
Affiliated Hospital of Nantong University
2019-2023
Nantong University
2019-2023
Background/Aims: Osteomyelitis is a debilitating infectious disease of the bone which predominantly caused by Staphylococcus aureus (S. aureus). The purpose this study was to investigate role S. virulence factors, i.e. protein A (SpA), Panton-Valentine leukocidin (PVL) and coagulase (Coa) on osteomyelitis. Methods: effect SpA, PVL Coa osteoblasts studied through following aspects including osteoblast proliferation, apoptosis, formation, mineralization RANK-L expression. overexpressing PVL,...
Abstract Background To evaluate the effectiveness of a sequential internal fixation strategy and intramedullary nailing with plate augmentation (IMN/PA) for bone reconstruction in management infected femoral shaft defects using Masquelet technique. Methods We performed retrospective descriptive cohort study 21 patients (mean age, 36.4 years) treated by technique minimum follow-up 18 months after second stage. After aggressive debridement, temporary stabilisation (T1) was achieved an...
Objectives: Nivolumab (nivo) in combination with ipilimumab (ipi) is approved the US for adults and adolescents (12 to < 18 years) melanoma 3L+ MSI-H/dMMR colorectal cancer (CRC). A MIDD approach was used support proposed dosing regimen (weighing ≥ 40 kg: nivo 240 mg + ipi 1 mg/kg Q3W x 4 doses, then Q2W or 480 Q4W; weighing 3 Q2W) 1L CRC by comparing simulated exposures between based on popPK models. Methods: The developed nivo/ipi pediatric models were updated include PK data from Study...
Objectives: This study aims to support the proposed dosing regimen for nivolumab (nivo) and ipilimumab (ipi) when administered in combination (nivo 240 mg + ipi 1 mg/kg Q3W x 4 doses, then nivo Q2W or 480 Q4W) subjects with 1L MSI-H/dMMR metastatic colorectal cancer (CRC) by characterizing PK E-R of ipi.Methods: Nivo/ipi has been extensively characterized multiple tumor types, including 2L+ CRC. The adequacy previously developed popPK models was validated through pcVPC plots confirm that...
Infection by methicillin-resistant Staphylococcus aureus (MRSA) is a life-threatening condition, and formation of biofilms can lead to treatment failure in clinical setting. The aim this study was demonstrate the vivo bactericidal effects combination vancomycin (VAN) fosfomycin (FOS) against MRSA rat carboxymethyl cellulose-pouch biofilm model. results time-kill assay showed that therapy capable killing at low minimal inhibitory concentrations (MIC) (½× MIC VAN +1× FOS 1× + FOS). In study,...
Childhood chronic haematogenous osteomyelitis (CCHOM) is a severe condition in paediatric patients. The optimal timing of debridement and the subsequent method bone reconstruction CCHOM patients remain controversial. purpose this study was to assess treatment efficacy Masquelet technique with early internal fixation long bones.Between January 2016 2021, total 21 (18 males, 3 females) were included. mean age 10.4 years (range, 2-18 years). All cases treated by two-stage surgical protocol...
Identification of infected lesions in chronic haematogenous osteomyelitis (CHOM) is challenging due to no distinct boundary. The optimal methods debridement and bone reconstruction remain controversial. aim this study was evaluate the clinical efficacy selective segmental osteotomy with induced membrane technique adult CHOM patients femur or tibia. who underwent a staged surgery were include. In first stage. treated by for according imaging result preoperatively. second stage, spacer...
The objective of this study was to design a novel artificial bone scaffold for therapy and prevention refractory bacterial infection. Porous β-tricalcium phosphate (β-TCP) combined with liposomal gentamicin (GS) form complex drug carrier. liposome β-TCP (LCS) characterized its binding rate, loading, micromorphology. anti-biofilm activity LCS evaluated by Staphylococcus aureus biofilm in vitro. release from recognized as an initial high dose GS released the matrix further sustained free...
Hydrolysis by lactase-phloridzin hydrolase (LPH) is the first and critical step in absorption of isoflavonoid glucosides. However, characteristics calycosin-7-<i>O</i>-<i>β</i>-d-glucoside (CG) slightly differ from other In this study, we used rat intestinal perfusion model performed pharmacokinetic studies vitro experiments to determine factors influencing CG disposition. After oral administration glucosides, LPH was found play minimal or no role on hydrolysis CG, contrast that daidzin....
To compare the effect of internal fixation vs. external after debridement in stage I Masquelet technique for Cierny-Mader (C-M) type Ⅳ chronic post-traumatic tibial osteomyelitis.This retrospective observational study included patients with osteomyelitis who underwent staged treatment between January 2016 and June 2020 at 920 Hospital Joint Logistic Support Force PLA. The were grouped according to they received I. Infection recurrence, time radiological bone healing full weight-bearing,...
A retrospective study was conducted on 148 spinal tuberculosis (TB) patients (M:F, 92:56; mean age, 39.7±12.3; range, 16-74 y) treated with anterior debridement and bone graft fusion nail screw internal fixation (nails+screws group); posterior pedicle (pedicle vertebral arch through a route (posterior or debridement, fusion, (arch group).We investigated 4 variant surgical approaches for of TB.The effectiveness single-stage different degrees TB is matter debate.Operation time bleeding volume...
Chondrocyte hypertrophy, a terminal stage of chondrocyte differentiation, is essential to the endochondral bone formation and one major pathological factors in osteoarthritis. This study investigated role microRNA-29b (miR-29b), which involved chondrogenesis, regulation hypertrophy chondrocytes.miR-29b expression was assessed during murine mesenchymal stem cells (mMSCs) chondrogenesis. To detect whether miR-29b affects mMSCs induced toward chondrogenesis were transfected with or its...
Abstract Background Genomic studies of colorectal cancer have revealed the complex genomic heterogeneity tumor. The acquisition and selection alterations may be critical to understanding initiation progression this disease. Methods In study, we systematically characterized clonal architecture 97 driver genes in 536 patients from TCGA. Results A high proportion mutations 93 were observed. 40 showed significant associations between their clonality multiple clinicopathologic factors....
Two-dimensional (2D) metal–organic frameworks (MOFs) have promising applications in surface plasmon resonance (SPR) sensing for their intriguing exciton migration and visible light-near infrared absorption properties. In this study, an effective biosensing structure comprising 2D Cu-TCPP MOF nanosheet-capsulated Au film was developed, such that lower molecular-weight dopamine with small changes of refractive index can be identified on the fiber-optic platform. The large areas ultrathin...
Toll-like receptor 4 (TLR4) plays a critical role in various human diseases, and was associated with pyroptotic cell death inflammatory responses. DNA methylation, which has stable reversible properties, been reported to alter the expression of target genes, including TLR4. However, methylated TLR4 osteomyelitis (OM) underlying molecular mechanisms remain unclear. RNA sequencing used identify differentially expressed genes signaling pathways. RT-qPCR, Western blot, emzyme-linked...
Sacrococcygeal pilonidal sinus is one of common diseases in general department. However, it characterised, for surgeons, by high post-surgical recurrence and incidence wound complications. Due to that fact, this retrospective randomised clinical study was designed evaluate the surgical procedure effect Z-plasty (ZP), compared with convention simple excision (SE). A total 67 patients from May 2015 2019 our department were studied into two groups randomly, group ZP SE. The patients'...
Honokiol is a lignan isolated from