A5010659344- Nitric Oxide and Endothelin Effects
- Receptor Mechanisms and Signaling
- Ion channel regulation and function
- Ion Channels and Receptors
- Neuroscience and Neuropharmacology Research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Neuropeptides and Animal Physiology
- Protein Kinase Regulation and GTPase Signaling
- Eicosanoids and Hypertension Pharmacology
- Advanced Glycation End Products research
- Heart Rate Variability and Autonomic Control
- Adipose Tissue and Metabolism
- Cardiovascular Issues in Pregnancy
- Renin-Angiotensin System Studies
- Gastrointestinal motility and disorders
- Caveolin-1 and cellular processes
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cardiomyopathy and Myosin Studies
- Cardiac Ischemia and Reperfusion
- Pharmacological Effects and Assays
- Ion Transport and Channel Regulation
- Connexins and lens biology
- Protein Tyrosine Phosphatases
- Cell Adhesion Molecules Research
- Free Radicals and Antioxidants
UNSW Sydney
2015-2025
RMIT University
1998-2003
Wake Forest University
2002
Monash Institute of Medical Research
1997-1999
University of Pittsburgh
1997
University of Bristol
1994-1995
University of Southampton
1994
The University of Melbourne
1989-1992
These recommendations of the Advisory Committee on Immunization Practices (ACIP) for poliomyelitis prevention replace those issued in 1997. As January 1, 2000, ACIP recommends exclusive use inactivated poliovirus vaccine (IPV) routine childhood polio vaccination United States. All children should receive four doses IPV at ages 2, 4, and 6-18 months 4-6 years. Oral (OPV) be used only certain circumstances, which are detailed these recommendations. Since 1979, indigenous cases reported States...
Diet-induced obesity is associated with changes in gastrointestinal function and induction of a mild inflammatory state. Serotonin (5-HT) containing enterochromaffin (EC) cells within the intestine respond to nutrients are altered by inflammation. Thus, our aim was characterize uptake release 5-HT from EC rat ileum physiologically relevant model diet-induced obesity. In chow-fed (CF) Western diet-fed (WD) rats electrochemical methods were used measure compression evoked (peak) steady state...
AimsMicrodomain signalling mechanisms underlie key aspects of artery function and the modulation intracellular calcium, with transient receptor potential (TRP) channels playing an integral role. This study determines distribution role TRP canonical type 3 (C3) in control endothelium-derived hyperpolarization (EDH)-mediated vasodilator tone rat mesenteric artery.
Arteriolar myogenic vasoconstriction occurs when increased stretch or membrane tension leads to smooth muscle cell depolarization and opening of voltage-gated Ca2+ channels. To prevent positive feedback excessive pressure-induced vasoconstriction, studies in cerebral artery have suggested that activation large conductance, Ca2+-activated K+ channels (BKCa) provides an opposing hyperpolarizing influence reducing channel activity. We hypothesized this mechanism may not equally apply all...
Reduction of vascular RGS5 causes hypertension and preeclampsia, which can be reversed by PPAR agonist treatment in mouse models.
In animal models and human cerebral arteries, the changes in endothelial cell (EC)-large conductance calcium-activated potassium channel (BKCa) distribution, expression, function were determined hypoxia ischemic stroke. The hypothesis that stroke induce EC-BKCa arteries was examined. Immunohistochemistry analyzed BKCa expression EC smooth muscle (SM) of middle-cerebral artery (MCA) from rat, piglet, mouse, pial arteriole human. Pressure myography with pharmacological intervention...
The mechanisms involved in altered endothelial function obesity-related cardiovascular disease are poorly understood. This study investigates the effect of chronic obesity on endothelium-dependent vasodilation and relative contribution nitric oxide (NO), calcium-activated potassium channels (K<sub>Ca</sub>), myoendothelial gap junctions (MEGJs) rat saphenous artery. Obesity was induced by feeding rats a cafeteria-style diet (∼30 kJ as fat) for 16 to 20 weeks, with this model reflecting human...
Myoendothelial microdomain signaling via localized calcium-activated potassium channel (K<sub>Ca</sub>) and gap junction connexins (Cx) is critical for endothelium-dependent vasodilation in rat mesenteric artery. The present study determines the relative contribution of NO junction-K<sub>Ca</sub> mediated to human hypothesis tested was that such activity due K<sub>Ca</sub> Cx activity. In arteries from intestinal surgery patients, characterized using pressure myography with pharmacological...
Mechanisms underlying obesity-related vascular dysfunction are unclear. This study examined the effect of diet-induced obesity on expression and function large conductance Ca 2+ -activated potassium channel (BK ) in rat pressurized small resistance vessels with myogenic tone. Male Sprague-Dawley rats fed a cafeteria-style high fat diet (HFD; ∼30% energy from fat) for 16–20 wk were heavier than controls standard chow (∼13% fat). Obesity did not alter BK α-subunit or protein mRNA isolated...
Agonists increase endothelial cell intracellular Ca 2+ , in part, by capacitative entry, which is triggered the filling state of stores. It has been suggested that depletion endoplasmic reticulum (ER) stores either leads to a physical coupling between ER and plasma membrane channel, or results production an messenger affects gating channels. As axis involving IP 3 receptor implicated mechanism aim this study was examine effects putative antagonists/modulators, 2 aminoethoxydiphenyl borate...
Constipation and slowed transit are associated with diet-induced obesity, although the mechanisms by which this occurs unclear. Enterochromaffin (EC) cells within intestinal epithelium respond to mechanical stimulation release of serotonin [5-hydroxytryptamine (5-HT)], promotes transit. Thus our aim was characterize 5-HT availability in rat colon a physiologically relevant model obesity. EC cell numbers were determined immunohistochemically chow-fed (CF) Western diet-fed (WD) rats, while...
Obesity is a risk factor for hypertension and other vascular disease. The aim of this study was to examine the effect diet-induced obesity on endothelium-dependent dilation rat cremaster muscle arterioles. Male Sprague-Dawley rats (213 ± 1 g) were fed cafeteria-style high-fat or control diet 16-20 wk. Control weighed 558 7 g compared with obese 762 12 (n = 52-56; P < 0.05). Diet-induced had no acetylcholine (ACh)-induced isolated, pressurized (70 mmHg) arterioles, but sodium nitroprusside...
Ca 2+ entry mechanisms underlying spontaneous arteriolar tone and acute myogenic reactivity remain uncertain. These studies aimed to compare the effects of nifedipine putative T‐channel blocker, mibefradil, on responsiveness intracellular (Ca i ). First order cremaster muscle arterioles (1A) were isolated from rats, cannulated, pressurized 70 mmHg in absence intraluminal flow, mechanical responses studied by video microscopy. The was measured using fluorescence imaging Fura 2 loaded...
Abstract In pregnancy, the vasculature of uterus undergoes rapid remodelling to increase blood flow and maintain perfusion fetus. The present study determines distribution density caveolae, transient receptor potential vanilloid type 4 channels ( TRPV 4) myoendothelial gap junctions, relative contribution related endothelium‐dependent vasodilator components in uterine radial arteries control virgin non‐pregnant 20‐day late‐pregnant rats. hypothesis examined is that specific mechanisms are...