A5022088163- Tea Polyphenols and Effects
- Antioxidant Activity and Oxidative Stress
- Phytochemicals and Antioxidant Activities
- Electrospun Nanofibers in Biomedical Applications
- Advanced biosensing and bioanalysis techniques
- Advanced Sensor and Energy Harvesting Materials
- Nanoplatforms for cancer theranostics
- Free Radicals and Antioxidants
- Nanoparticle-Based Drug Delivery
- Advanced Chemical Sensor Technologies
- Neuroscience and Neural Engineering
- Biosensors and Analytical Detection
- Conducting polymers and applications
- DNA and Nucleic Acid Chemistry
- Otolaryngology and Infectious Diseases
- Polymer Surface Interaction Studies
- Mass Spectrometry Techniques and Applications
- Extracellular vesicles in disease
- Advanced Nanomaterials in Catalysis
- Radiation Effects and Dosimetry
- Graphene and Nanomaterials Applications
- Atherosclerosis and Cardiovascular Diseases
- Photochromic and Fluorescence Chemistry
- Silk-based biomaterials and applications
- Spectroscopy Techniques in Biomedical and Chemical Research
Instituto de Telecomunicações
2015-2025
University of Lisbon
2015-2025
Universidade Nova de Lisboa
2016-2025
Centro Hospitalar de Entre o Douro e Vouga E.P.E.
2025
Rede de Química e Tecnologia
2023-2024
Instituto Politécnico de Lisboa
2019-2021
Instituto Politécnico da Guarda
2016
Polymeric scaffolds incorporating plant-derived compounds, produced by electrospinning, have attracted attention in the field of skin tissue engineering. This study evaluates sustained antioxidant activity polycaprolactone (PCL)/gelatin nanofibers prepared electrospinning and loaded liposomes epigallocatechin-3-gallate (EGCG), a strong antibacterial molecule found green tea, that significantly accelerates wound-healing process. The morphology structural properties membranes were...
The control of angiogenesis has the potential to be used for regulation several pathological and physiological processes, which can instrumental on development anticancer wound healing therapeutical approaches. In this study, mesenchymal stem/stromal cells (MSCs) were seeded magnetic-responsive gelatin, with or without heparin functionalization, exposed a static 0.08 T magnetic field (MF), controlling their anti-inflammatory angiogenic activity, aim accelerating tissue healing. For first...
In this work, the spectroscopy of epigallocatechin-3-gallate (EGCG) and EGCG bonded to 1,2-dipalmitoyl-sn-glycero-3-phospho-(1′-rac-glycerol) (sodium salt) (DPPG) lipid is studied both experimentally by combining high-resolution vacuum ultraviolet (VUV) photo-absorption measurements in 4.0–9.0 eV energy range theoretical calculations using density functional theory (DFT) methodology. There a good agreement between experimental data, inclusion solvent implicitly explicitly further improves...
Cancer cells possess distinct bioelectrical properties, yet therapies leveraging these characteristics remain underexplored. Herein, we introduce an innovative nanobioelectronic system combining a piezoelectric barium titanate nanoparticle core with conducting poly(3,4-ethylenedioxythiophene) shell (BTO@PEDOT NPs), designed to modulate cancer cell bioelectricity through noninvasive, wireless stimulation. Our hypothesis is that acting as nanoantennas, BTO@PEDOT NPs convert mechanical inputs...
Abstract Background: The subgluteal space encompasses a range of complex pathologies critical to sports medicine and orthopedic practices. Understanding the diverse clinical presentations varying treatment responses is crucial for enhancing patient care surgical outcomes. Recognizing significance each patient’s unique profile equally important, as it significantly influences choice effectiveness strategies, ensuring that interventions are tailored individual needs circumstances. Objective:...
This work explores the unique features of magnetic-responsive hydrogels to obtain liposomal hydrogel delivery platforms capable precise magnetically modulated drug release based on mechanical responses these when exposed an external magnetic field. Magnetic-responsive systems were prepared by encapsulation 1,2-dipalmitoyl-sn-glycero-3-phosphocoline (DPPC) multilayered vesicles (MLVs) loaded with ferulic acid (FA), i.e., DPPC:FA liposomes, into gelatin membranes containing dispersed iron...
Catechins are molecules with potential use in different pathologies such as diabetes and cancer, but their pharmaceutical applications often hindered by instability the bloodstream. This issue can be circumvented using liposomes nanocarriers for vivo delivery. In this work, we studied molecular details of (-)-epigallocatechin-3-gallate (EGCG) interacting 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) monolayer/bilayer systems to understand catechin loading ability liposome stability,...
Ultraviolet (UV) radiation has a strong influence in the damage of deoxyribonucleic acid (DNA). In this work, possibility DNA UV dosimeter is evaluated. For that, calf thymus samples, thin films and aqueous solutions, were irradiated with 254 nm wavelength light during different periods time, being caused by irradiation analysed both UV-visible infrared spectroscopies. As polyelectrolyte, pH samples was also considered as variable. Results demonstrated that takes place solutions when at nm,...
The photosensitizer methylene blue (MB) has been investigated as a deoxyribonucleic acid (DNA) intercalant with the main objective of understanding chemical/physical processes, which occur when adequate wavelength light is impinging on DNA intercalated MB. This crucial for creation dynamic phototherapy procedures and development new dye sensitized solar cells. During this work we developed optimized all conditions to efficiently produce [MB/DNA] multi-layered films by self-assembly. Our...
Metabolomics of biofluids as plasma implies the sample pre-processment to eliminate diverse macromolecules proteins. The optimization this procedure is conducted according main method analyses metabolome and type metabolites be studied. In present work, it was evaluated effect processes from samples on profile achieved by mid-infrared spectroscopy. It proteins extraction methanol, acetone acetonitrile. highest efficiency protein observed with acetone, been 2.4- 4.7-fold lower quantities in...
Abstract Study question Can we detect the variation in different commercial human embryo culture media composition by Fourier-transform infrared (FTIR) spectroscopic analysis? Summary answer The spectra reveals distint features that allow distinguishing between continuous and sequential media, as well manufacturers of same type. What is known already: Manufacturers do not fully disclose commercially available formulations. For this reason, it important to gain insight into de differences...