Akhil Jain

ORCID: 0000-0003-2019-2030
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About
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Research Areas
  • Neuroscience and Neural Engineering
  • Advanced biosensing and bioanalysis techniques
  • Electrochemical Analysis and Applications
  • Molecular Communication and Nanonetworks
  • Nanoplatforms for cancer theranostics
  • Gold and Silver Nanoparticles Synthesis and Applications
  • Luminescence Properties of Advanced Materials
  • Photodynamic Therapy Research Studies
  • biodegradable polymer synthesis and properties
  • Microplastics and Plastic Pollution
  • Advanced Sensor and Energy Harvesting Materials
  • Microbial Fuel Cells and Bioremediation
  • Molecular Junctions and Nanostructures
  • Cannabis and Cannabinoid Research
  • Acute Myeloid Leukemia Research
  • Electrochemical sensors and biosensors
  • Advanced Nanomaterials in Catalysis
  • Cancer survivorship and care
  • Porphyrin and Phthalocyanine Chemistry
  • Chemotherapy-induced cardiotoxicity and mitigation
  • Cancer Genomics and Diagnostics
  • CAR-T cell therapy research
  • Nanoparticles: synthesis and applications
  • Photoreceptor and optogenetics research
  • Microwave-Assisted Synthesis and Applications

University of Manchester
2024-2025

University of Iowa Hospitals and Clinics
2025

University of Iowa
2025

University of Nottingham
2018-2024

New York Medical College
2024

The University of Texas MD Anderson Cancer Center
2024

The University of Texas Rio Grande Valley
2024

Catholic Medical Center
2021-2023

Mercy Catholic Medical Center
2021-2023

Mercy Fitzgerald Hospital
2023

Abstract Quantum biological tunnelling for electron transfer is involved in controlling essential functions life such as cellular respiration and homoeostasis. Understanding the quantum effects biology has potential to modulate functions. Here we merge wireless nano-electrochemical tools with cancer cells control over trigger cell death. Gold bipolar nanoelectrodes functionalized redox-active cytochrome c a redox mediator zinc porphyrin are developed electric-field-stimulating bio-actuators,...

10.1038/s41565-023-01496-y article EN cc-by Nature Nanotechnology 2023-09-14

Abstract Bioelectronic medicine is a treatment modality that uses electricity to treat disease by altering the body's electrical communication systems. All cells are electrically active, in they possess bioelectric circuitry generating resting membrane potential and endogenous electric fields influence cell functions communication. There now an accepted paradigm cancer characterized malfunctions cells’ bioelectrical circuitry. This yields opportunities for bioelectronic as novel treatments...

10.1002/adtp.202000248 article EN Advanced Therapeutics 2021-01-15

Osteoporotic-related fractures are among the leading causes of chronic disease morbidity in Europe and US. While a significant percentage can be repaired naturally, delayed-union non-union surgical intervention is necessary for proper bone regeneration. Given current lack optimized clinical techniques to adequately address this issue, tissue engineering (BTE) strategies focusing on development scaffolds temporarily replacing damaged supporting its regeneration process have been gaining...

10.1080/14686996.2023.2242242 article EN cc-by Science and Technology of Advanced Materials 2023-08-24

Breast cancer is the second leading cause of death among women and represents 14% in around world. The standard diagnosis method for breast tumor mammography, which often related with false-negative results to therapeutic delays contributing indirectly development metastasis. Therefore, new tools that can detect an urgent need reduce mortality women. Here, we have developed Gd2O3:Eu3+ nanoparticles functionalized folic acid (FA), detection. were synthesized by sucrose assisted combustion...

10.1186/s12951-018-0359-9 article EN cc-by Journal of Nanobiotechnology 2018-03-22

Photodynamic therapy is a promising cancer modality but its application for deep-seated tumor mainly hindered by the shallow penetration of visible light. X-ray-mediated photodynamic (PDT) has gained major attention owing to limitless X-rays. However, substantial outcomes have still not been achieved due low luminescence efficiency scintillating nanoparticles and weak energy transfer photosensitizer. The present work describes development Y2.99Pr0.01Al5O12-based (YP) mesoporous silica coated...

10.1186/s12951-018-0344-3 article EN cc-by Journal of Nanobiotechnology 2018-02-26

We report the surface modification of nanocrystalline Gd2O3:Eu3+ phosphor by (3-Aminopropyl)trimethoxysilane (APTMS). The nanoparticles were first coated with silica using Stöber process, and then annealed at 650 °C for 2 h. Afterwards, APTMS was functionalized onto layer to obtain bearing amine groups on surface. effect coating, subsequent annealing process crystallization nanophosphor analyzed x-ray diffraction (XRD). High-resolution transmission electron microscopy (HR-TEM) confirmed...

10.1088/0957-4484/27/6/065601 article EN Nanotechnology 2015-12-18

For the field of bioelectronics to make an impact on healthcare, there is urgent requirement for development "wireless" electronic systems enable modulation chemistry inside cells. Herein we report intracellular wireless communication system. This based modulating electrochemistry gold nanoparticles without having any physical electrical connection a power supply at relatively low externally applied potentials. The system made functional by modifying water-soluble (ws-AuNPs) with Zn(II)...

10.1021/acsanm.9b01374 article EN ACS Applied Nano Materials 2019-09-05

Multifunctional gold nanoparticles (AuNPs) are of great interest, owing to their vast potential for use in many areas including sensing, imaging, delivery, and medicine. A key factor determining the biological activity multifunctional AuNPs is quantification surface conjugated molecules. There has been a lack accurate methods determine this multifunctionalized AuNPs. We address limitation by using new method based on deconvolution Levenberg–Marquardt algorithm fitting UV–visible absorption...

10.1021/acs.analchem.3c01649 article EN cc-by Analytical Chemistry 2023-08-25

Cancer cells possess distinct bioelectrical properties, yet therapies leveraging these characteristics remain underexplored. Herein, we introduce an innovative nanobioelectronic system combining a piezoelectric barium titanate nanoparticle core with conducting poly(3,4-ethylenedioxythiophene) shell (BTO@PEDOT NPs), designed to modulate cancer cell bioelectricity through noninvasive, wireless stimulation. Our hypothesis is that acting as nanoantennas, BTO@PEDOT NPs convert mechanical inputs...

10.1021/acsami.4c12387 article EN ACS Applied Materials & Interfaces 2025-01-29

BACKGROUND The burden of cannabis use disorder (CUD) in the context its prevalence and subsequent cardiopulmonary outcomes among cancer patients with severe sepsis is unclear. AIM To address this knowledge gap, especially due to rising patterns emerging pharmacological role cancer. METHODS By applying relevant International Classification Diseases, Ninth Tenth Revision, Clinical Modification codes National Inpatient Sample database between 2016-2020, we identified CUD(+) CUD(-) arms adult...

10.5492/wjccm.v14.i2.100844 article EN World Journal of Critical Care Medicine 2025-02-27

"CLO25-062: Prevalence of Cannabis Use Disorder Among Hospitalized Elderly Cancer Survivors: Nationwide Trends and Disparities (2016–2020)" published on 28 Mar 2025 by National Comprehensive Network.

10.6004/jnccn.2024.7219 article EN Journal of the National Comprehensive Cancer Network 2025-03-28

"CLO25-089: The Prognostic Value of the Endothelial Activation and Stress Index (EASIX) in Predicting Clinical Survival Outcomes Treatment Response for Patients Undergoing Chimeric Antigen Receptor T-Cell (CAR-T) Therapy" published on 28 Mar 2025 by National Comprehensive Cancer Network.

10.6004/jnccn.2024.7218 article EN Journal of the National Comprehensive Cancer Network 2025-03-28

"CLO25-066: Prognostic Role of Pre-Transplant EASIX on Non-Relapse Mortality and Overall Survival in Allogeneic Stem Cell Transplantation: A Meta-Analysis" published 28 Mar 2025 by National Comprehensive Cancer Network.

10.6004/jnccn.2024.7211 article EN Journal of the National Comprehensive Cancer Network 2025-03-28

Abstract Introduction: CAR-T cell therapy represents a significant advancement in the management of relapsed/refractory hematological malignancies. Adverse events include cytokine release syndrome (CRS), infections, and neurological cardiovascular events. Though real-world data from referral centers regarding uptake different populations incidence various adverse are available, we used National Inpatient Sample (NIS) with weighted analysis to provide contemporary representing national...

10.1158/1538-7445.am2025-3375 article EN Cancer Research 2025-04-21
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