A5008737039- Global Cancer Incidence and Screening
- BRCA gene mutations in cancer
- Cancer Risks and Factors
- Diet and metabolism studies
- Mobile Health and mHealth Applications
- Colorectal Cancer Screening and Detection
- Eating Disorders and Behaviors
- Obesity and Health Practices
- Bariatric Surgery and Outcomes
- Nutritional Studies and Diet
- Dietary Effects on Health
- Cervical Cancer and HPV Research
- Medical Coding and Health Information
- Climate Change Communication and Perception
- Language Development and Disorders
- Health Promotion and Cardiovascular Prevention
- Genomics and Rare Diseases
- Public Procurement and Policy
- Genomic variations and chromosomal abnormalities
- Digital Mental Health Interventions
- Health Literacy and Information Accessibility
- Health Systems, Economic Evaluations, Quality of Life
- Corporate Social Responsibility Reporting
- Family and Disability Support Research
- Family Support in Illness
Manchester University NHS Foundation Trust
2019-2024
Wythenshawe Hospital
2023
Dublin City University
2018
Manchester Royal Infirmary
2010
Health Service Executive
2008
Abstract Background In principle, risk-stratification as a routine part of the NHS Breast Screening Programme (NHSBSP) should produce better balance benefits and harms. The main benefit is offer NICE-approved more frequent screening and/ or chemoprevention for women who are at increased risk, but unaware this. We have developed BC-Predict, to be offered when invited NHSBSP which collects information on risk factors (self-reported family history hormone-related via questionnaire; mammographic...
Abstract Background UK national guidelines suggest women at high-risk of breast cancer should be offered more frequent screening or preventative medications. Currently, only 1 in 6 are identified. One route to identify is via multifactorial risk assessment as part the UK’s NHS Breast Screening Programme (NHSBSP). As lower socioeconomic and minority ethnic populations continue experience barriers screening, it important that any new service does not exacerbate issues further. To inform...
Abstract Background Providing women with personalized estimates of their risk developing breast cancer, as part routine cancer screening programmes, allows at higher to be offered more frequent or drugs reduce risk. For this feasible, the concept and practicalities have acceptable healthcare professionals who would put it in practice. The present research investigated acceptability were responsible for implementation new approach ongoing BC-Predict study. Methods Four focus groups conducted...
Abstract Background Adding risk stratification to standard screening via the NHS Breast Screening Programme (NHSBSP) allows women at higher be offered additional prevention and options. It may, however, introduce new harms such as increasing cancer worry. The present study aimed assess whether there were differences in self-reported benefits between (BC-Predict) compared NHSBSP, controlling for baseline values. Methods As part of larger PROCAS2 (NCT04359420), 5901 NHSBSP or BC-Predict...
Abstract Background Risk-stratified screening is being considered for national breast programmes. It unclear how women experience risk-stratified and receipt of cancer risk information in real time. This study aimed to explore the psychological impact undergoing within England’s NHS Breast Screening Programme. Methods Individual telephone interviews were conducted with 40 who participated BC-Predict received a letter indicating their estimated as one four categories: low (<2% 10-year...
Abstract Background The Manchester Intermittent versus Daily Diet App Study (MIDDAS) tested the feasibility and potential efficacy of two remotely delivered low‐energy diet (LED) programmes (800 kcal/day) to support weight loss remission type 2 diabetes: continuous [CLED] (8 weeks daily LED) intermittent [ILED] (2 days LED/week for 28 weeks). Understanding participant experiences can help us understand acceptability LED people with diabetes, informing future programme development...
Previous research has largely attempted to explore breast screening experiences of South Asian women by combining opinions from Pakistani, Bangladeshi, and Indian women. This often fails reach the most underserved sub-groups this population, with socioeconomic status not routinely reported, English fluency being a participation requirement. With uptake low amongst British-Pakistani women, study explores these encounter when accessing NHS Breast Screening Programme.19 one-to-one...
Excess body weight and sub-optimal lifestyle are modifiable causes of breast cancer other diseases. There is little evidence that behaviour change possible within screening programmes whether this influenced by prior knowledge disease risk. We determined risk influences uptake, retention efficacy a control programme in the UK National Health Service Breast Screening Programme, additional cardiovascular type 2 diabetes information improves uptake further.Overweight/obese women Programme...
Abstract Background Risk stratification as a routine part of the NHS Breast Screening Programme (NHSBSP) could provide better balance benefits and harms. We developed BC-Predict, to offer women when invited NHSBSP, which collects standard risk factor information; mammographic density; in sub-sample, Polygenic Score (PRS). Methods prediction was estimated primarily from self-reported questionnaires density using Tyrer–Cuzick model. Women eligible for NHSBSP were recruited. BC-Predict produced...
To assess the contribution of germline pathogenic variants (PVs) in population-based series breast cancers and best strategy to improve detection rates.
Risk stratified breast cancer screening is being considered as a means of improving the balance benefits and harms mammography. Stratified requires communication risk estimates. We aimed to co-develop personalised 10-year communications for women attending routine mammography.We conducted think-aloud interviews on prototype letters accompanying information leaflets with receiving through UK National Breast Screening Programme. was redesigned following feedback from 55 in three iterations. A...
Abstract Aims To test the feasibility and potential efficacy of remotely supported intermittent low‐energy diets (ILEDs) continuous (CLEDs) in people with type 2 diabetes (T2D) a randomized controlled trial comparing two approaches. Materials methods Seventy‐nine adults overweight/obesity T2D (≤8 years duration) were 1:1 to CLED (8 weeks/56 days daily Optifast 820 kcal (3430 kJ) diet) or isoenergetic ILED (2 5 Mediterranean diet/week for 28 weeks). Weight maintenance/continued weight loss...
Abstract Background Excess weight and unhealthy behaviours (e.g. sedentariness, high alcohol) are common amongst women including those attending breast screening. These factors increase the risk of cancer other diseases. We tested feasibility acceptability a loss/behaviour change programme framed to reduce (breast prevention programme, BCPP) compared one cancer, cardiovascular disease (CVD) diabetes (T2D) (multiple MDPP). Methods Women aged 47-73 years with overweight or obesity ( n = 1356)...
Economic evaluations have suggested that risk-stratified breast cancer screening may be cost-effective but used assumptions to estimate the cost of risk prediction. The aim this study was identify and quantify resource use associated costs required introduce a risk-stratification approach into English national program.
Three criteria for diagnosing specific language impairment (SLI) are defined in the literature: exclusionary definitions, inclusionary and qualitative markers. However, assessment diagnosis of this complex clinical practice can be challenging. The aims research were twofold: (1) to make explicit current procedures which speech therapists (SLTs) use when they diagnose children with SLI Ireland, (2) explore SLT's perceptions experiences process SLI. Both quantitative methods used study. A...
Background Intensive face-to-face weight loss programs using continuous low-energy diets (CLEDs) providing approximately 800 kcal per day (3347 kJ day) can produce significant and remission from type 2 diabetes (T2D). Intermittent (ILEDs) remotely delivered could be viable alternatives that may support patient choice adherence. Objective This paper describes the protocol of a pilot randomized controlled trial to test feasibility potential efficacy supported isocaloric ILED CLED among...
Breast cancer incidence is rising among Pakistani women in the United Kingdom. However, uptake of breast screening remains low. This study aimed to improve access for British-Pakistani by exploring their knowledge and role primary care community networks support amongst women.We undertook a secondary qualitative analysis 18 semi-structured interviews with from East Lancashire Anonymized transcripts were used thematic analysis.Three themes identified interviewees' responses: (i) 'Women's...
While Corporate Social Responsibility (CSR) and associated reporting has been studied extensively, little research done from a longitudinal perspective. This paper explores the presentational changes in CSR disclosures annual reports of an electricity company over period 1986 to 2017 using themes methods drawn extant research. The analysis shows are general reflective external factors such as legislation, economic crises, frameworks organisation’s competitive environment. A more stable level...