A5002706508- Respiratory viral infections research
- Congenital Diaphragmatic Hernia Studies
- Parvovirus B19 Infection Studies
- Neonatal Respiratory Health Research
- SARS-CoV-2 and COVID-19 Research
- Pneumonia and Respiratory Infections
- Viral gastroenteritis research and epidemiology
- Virology and Viral Diseases
- Animal Virus Infections Studies
University of Georgia
2019-2020
Human metapneumovirus (hMPV) is a leading cause of viral respiratory infection in children, and can severe lower tract infants, the elderly, immunocompromised patients. However, there remain no licensed vaccines or specific treatments for hMPV infection. Although fusion (F) protein sole target neutralizing antibodies, immunological properties F poorly understood. To further define humoral immune response to protein, we isolated two new human monoclonal antibodies (mAbs), MPV458 MPV465. Both...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of most recent global pandemic that has caused more than a million deaths around world. The spike glycoprotein (S) drives entry and fusion this virus main determinant cell tropism. To explore S requirements for under BSL2 conditions, been pseudotyped onto vesicular stomatitis (VSV) or retroviral particles with varied success. Several alterations to were demonstrated improve pseudoparticle titers, but they...
Human metapneumovirus (hMPV) is a leading cause of viral lower respiratory tract infection in children. The sole target neutralizing antibodies targeting hMPV the fusion (F) protein, class I protein mediating virus-cell membrane fusion. There have been several monoclonal (mAbs) isolated that neutralize hMPV; however, determining antigenic sites on F such antibody generation would assist efforts for effective vaccine design. In this report, isolation and characterization four new human mAbs,...
Abstract Human metapneumovirus is a leading cause of viral respiratory infection in children, and can severe lower infants, the elderly, immunocompromised patients. However, there remain no licensed vaccines or specific treatments for hMPV infection. Although fusion (F) protein sole target neutralizing antibodies, immunological properties F are still poorly understood. To further define humoral immune response to protein, we isolated two new human monoclonal antibodies (mAbs), MPV458 MPV465....
Abstract Human metapneumovirus (hMPV) is a leading cause of lower respiratory tract infection in infants and children, yet there currently no vaccine available for prevention hMPV disease. has three surface proteins: the small hydrophobic, attachment, fusion (F) protein. The F protein sole target neutralizing antibodies. To develop new therapeutics disease intervention to inform development an effective vaccine, we isolated several human monoclonal antibodies (mAbs) A subset these mAbs were...