A5101974474- Acute Myocardial Infarction Research
- Diabetes Treatment and Management
- Diabetes Management and Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Systems, Economic Evaluations, Quality of Life
- Metabolism, Diabetes, and Cancer
- Pneumonia and Respiratory Infections
- Lipoproteins and Cardiovascular Health
- Blood Pressure and Hypertension Studies
- Diabetes Management and Education
- Heart Failure Treatment and Management
- Chronic Disease Management Strategies
- Coronary Interventions and Diagnostics
- Emergency and Acute Care Studies
- Frailty in Older Adults
- Nutritional Studies and Diet
- Cardiac Imaging and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Respiratory viral infections research
- Pancreatic function and diabetes
- Pneumocystis jirovecii pneumonia detection and treatment
- Cardiac Health and Mental Health
- Nutrition and Health in Aging
- Pharmaceutical Economics and Policy
Universidad de Guadalajara
2024
AstraZeneca (Spain)
2014-2023
AstraZeneca (United Kingdom)
2014-2022
Hospital Royo Villanova
2019
Klinikum Ludwigshafen
2017
Hospital General Universitario Gregorio Marañón
2015
King's College London
2008
BackgroundThere is a shortage of information on regional variations in ST-segment elevation myocardial infarction (STEMI) management and prognosis at global level. We aimed to compare patient profiles, in-hospital post-discharge mortality across several world regions.MethodsIn total, 11,559 patients with STEMI were enrolled two prospective studies acute coronary syndrome survivors: EPICOR (4943 from 555 hospitals 20 countries Europe Latin America recruited between September 2010 March 2011)...
Complicated skin and soft tissue infections (cSSTI) are common frequently require treatment in hospital. Comprehensive current data on management practices patients hospitalized with cSSTI limited. REACH was a retrospective, observational cohort study designed to provide clinical of moderate severe European hospitals. Data were collected via an electronic case report form from 129 sites ten countries. The population comprised ≥18 years, between March 2010 February 2011 who received...
<ns4:p>Stakeholders in healthcare are increasingly turning to real world evidence (RWE) inform their decisions, alongside from randomized controlled trials. RWE is generated by analysing data gathered routine clinical practice, and can be used across the product lifecycle, providing insights into areas including disease epidemiology, treatment effectiveness safety, health economic value impact. Recently, US Food Drug Administration European Medicines Agency have stated ambition for greater...
<b>Objective</b> To determine levels of blood pressure monitoring and control in primary care to the effect social deprivation on these levels. <b>Design</b> Retrospective longitudinal survey, 2005 2007. <b>Setting</b> General practices England. <b>Participants</b> Data obtained from 8515 (99.3% all practices) year 1, 8264 (98.3%) 2, 8192 (97.8%) 3. <b>Main outcome measures</b> Blood indicators chronic disease prevalence estimates contained within UK quality outcomes framework; scores for...
A reliable prediction tool is needed to identify acute coronary syndrome (ACS) patients with high mortality risk after their initial hospitalization. EPICOR (long-tErm follow uP of antithrombotic management patterns In CORonary patients: NCT01171404) a prospective cohort study 10,568 consecutive hospital survivors an ACS event (4943 ST-segment elevation myocardial infarction (STEMI) and 5625 non-ST-elevation (NSTE-ACS)). Of these cases, 65.1% underwent percutaneous intervention (PCI) 2.5%...
Contemporary global real-world data on the management of type 2 diabetes are scarce. The DISCOVER study program aims to describe disease patterns and a broad range associated outcomes in patients with initiating second-line glucose-lowering therapy routine clinical practice. comprises two longitudinal observational studies involving more than 15,000 38 countries across six continents. Study sites have been selected be representative each country. Data will collected at baseline (initiation...
Patients discharged after an acute coronary syndrome (ACS) have substantial risk of recurrent ischemic events or dying.A difference may exist in predictors for all-cause mortality and between year 1 2 follow-up post-ACS.EPICOR (NCT01171404) was a prospective, international, real-world cohort study consecutive patients hospitalized ACS within 24 hours symptom onset surviving to discharge. Total 10 568 were enrolled (555 hospitals; 20 countries) followed-up years. From these, 4943 admitted...
<ns4:p>Stakeholders in healthcare are increasingly turning to real world evidence (RWE) inform their decisions, alongside from randomized controlled trials. RWE is generated by analysing data gathered routine clinical practice, and can be used across the product lifecycle, providing insights into areas including disease epidemiology, treatment effectiveness safety, health economic value impact. Recently, US Food Drug Administration European Medicines Agency have stated ambition for greater...
Elevated C-reactive protein (CRP) levels are associated with high cardiovascular risk, and might identify patients who could benefit from more carefully adapted risk factor management. We have assessed the prevalence of elevated CRP in one or traditional factors. Data were analysed European Study on Cardiovascular Risk Prevention Management Usual Daily Practice (EURIKA, ClinicalTrials.gov Identifier: NCT00882336 ), which included (aged ≥50 years) 12 countries at least but no history disease....
Aim To investigate determinants of change in glycated haemoglobin (HbA1c) patients with type 2 diabetes mellitus (T2DM) at 6 months after initiating uninterrupted second‐line glucose‐lowering therapies. Materials and Methods This cohort study utilized retrospective data from 10 256 T2DM who initiated therapy (switch or add‐on to metformin) between 2011 2014 Germany the UK. Effects pre‐specified patient characteristics on 6‐month HbA1c changes were assessed using analysis covariance. Results...
<h3>Objective</h3> To describe international patterns of dual antiplatelet therapy (DAPT) duration after acute coronary syndrome (ACS), and explore its determinants correlation with clinical events. <h3>Methods</h3> EPICOR (long-tErm follow-uP anti-thrombotic management In CORonary patients) is a prospective, international, observational study 10 568 ACS hospital survivors enrolled in 555 centres from 20 countries across Europe Latin America between 2010 2011, telephone follow-up at...
To describe international patterns and opportunities for improvement of pre- in-hospital care patients hospitalized acute coronary syndromes (ACS), with special focus on anti-thrombotic therapy. EPICOR (long-tErm follow-uP management In CORonary syndrome patients), an international, cohort study, which enrolled 10,568 consecutive ACS survivors from 555 hospitals in 20 countries across Europe Latin America (September 2010 to March 2011), prospectively registered detailed information...
Background: Long-term risk of post-discharge mortality associated with acute coronary syndrome remains a concern. The development model to reliably estimate two-year from hospital discharge post-acute will help guide treatment strategies. Methods: EPICOR (long-tErm follow uP antithrombotic management patterns In CORonary patients, NCT01171404) and Asia (EPICOR Asia, NCT01361386) are prospective observational studies 23,489 patients hospitalized for an event, who survived were then followed...
Intensification of metformin monotherapy with additional glucose-lowering drugs is often required in patients type 2 diabetes (T2D). This study evaluated changes HbA1c and weight, as well treatment persistence, associated different second-line therapies used UK clinical practice. The Clinical Practice Research Datalink was to identify T2D who initiated therapy after between 1 August 2013 14 June 2016. Treatment persistence weight were assessed at 6-month intervals up 18 months. In total,...
DISCOVER is a 3-year observational study program of 15,983 people with type 2 diabetes initiating second-line glucose-lowering therapy in 38 countries. We investigated the association between socioeconomic status and both availability baseline glycated hemoglobin (HbA1c) measurement poor glycemic control (HbA1c level ≥ 9.0%) participants enrolled DISCOVER. Factors associated lack HbA1c or an 9.0% were assessed using three-level hierarchical logistic models. Overall, 19.1% did not have...
Throughout Europe, physicians face similar challenges in non-small cell lung cancer (NSCLC) management, but comprehensive international information on usual clinical practice is lacking so the burden of NSCLC not fully understood.This multinational, multicentre, non-interventional study (NCT00831909) was conducted eight European countries. Patients with confirmed were consecutively enrolled from January to March 2009 and followed for 12 months or until death. Information collected patient...
The treatment of complicated skin and soft tissue infections (cSSTI) is challenging many patients do not receive adequate first-line therapy. REACH (REtrospective Study to Assess the Clinical Management Patients With Moderate-to-Severe cSSTI or Community-Acquired Pneumonia in Hospital Setting) was a retrospective observational study real-life settings European hospitals. In this analysis, we review characteristics outcomes with an early response (≤72 hours) compared those without treatment....
Background: Atrial fibrillation (AF) is associated with increased morbidity in acute coronary syndrome patients, but impact on outcomes beyond 1 year unclear. Methods: This was a post-hoc analysis from the long-tErm follow-uP of antithrombotic management patterns In CORonary patients (EPICOR) registry (NCT01171404), prospective, observational study conducted Europe and Latin America, which enrolled survivors at discharge. Antithrombotic patterns, mortality, composite endpoint death/new...