A5048759650- Receptor Mechanisms and Signaling
- Photoreceptor and optogenetics research
- Neural dynamics and brain function
- Advanced Fluorescence Microscopy Techniques
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Neuropeptides and Animal Physiology
- Olfactory and Sensory Function Studies
- Ion channel regulation and function
- Neurotransmitter Receptor Influence on Behavior
- Advanced Chemical Sensor Technologies
- Transcranial Magnetic Stimulation Studies
- Biochemical Analysis and Sensing Techniques
- Nicotinic Acetylcholine Receptors Study
University of California, Los Angeles
2022-2023
National Institute on Drug Abuse
2022
National Institutes of Health
2022
Instituto Politécnico Nacional
2020
Center for Research and Advanced Studies of the National Polytechnic Institute
2020
A main rationale for the role of G protein-coupled receptor (GPCR) heteromers as targets drug development is putative ability selective ligands specific GPCRs to change their pharmacological properties upon GPCR heteromerization. The present study provides a proof concept this by demonstrating that heteromerization dopamine D1 and D3 receptors (D1R D3R) influences three structurally similar D3R ligands, phenylpiperazine derivatives PG01042, PG01037 VK4–116. By using D1R-D3R...
Abstract Dopamine D 3 R are widely expressed in basal ganglia where interact with 1 R. potentiate cAMP accumulation and GABA release stimulated by striatonigral neurons through “atypical” signaling. During dopaminergic denervation, signaling changes to a “typical” which antagonizes the effects of R, mechanisms this switching unknown. nf splice variant regulates membrane anchorage function decreases denervation; thus, it is possible that correlates expression increases membranal mask atypical...
Abstract Intrinsic optical signal imaging (IOSI) is a staple technique in modern neuroscience. Pioneered >30 years ago, IOSI allows macroscopic mapping of neuronal activity throughout the cortex. The has been used to study sensory processing and experience-dependent plasticity, often as an adjunctive procedure localize cortical areas for subsequent targeting by other or physiology techniques. Despite ubiquity neuroscience, there are few commercially available turn-key systems. As result,...
Abstract Intrinsic optical signal imaging (IOSI) is a staple technique in modern neuroscience. Pioneered over thirty years ago, IOSI allows macroscopic mapping of neuronal activity throughout the cortex. The has been used to study sensory processing and experience-dependent plasticity, often as an adjunctive procedure localize cortical areas for subsequent targeting by other or physiology techniques. Despite ubiquity neuroscience there are few commercially available systems. As result,...