This communication presents a fluorescent chemosensor for detecting Pb(II) and Hg(II) in aqueous solutions. The sensor showed turn-on response to by an enhancement of emission intensity at 380 nm intensities 475 nm. We have first characterized unique function tryptophan as ligand well quencher recognition change metal binding event.

A fluorescent peptidyl chemosensor for the detection of heavy metal ions in aqueous solution as well cells was synthesized on basis peptide receptor using an aggregation-induced emission fluorophore. The (1) bearing tetraphenylethylene fluorophore showed exclusively selective turn-on response to Hg2+ among 16 buffered containing NaCl. complexed and then aggregated solution, resulting significant enhancement (OFF-On) emissions at around 470 nm. sensor a highly sensitive Hg2+, about 1.0 equiv...

An amino acid-based fluorescent sensor (3) bearing a triazole group was synthesized by solid phase synthesis using click chemistry. 3 showed highly sensitive ratiometric response to Hg2+ in 100% aqueous solution. The dissociation constant for solution calculated be 672 nM. exhibited selective among 13 tested metal ions and the detection of not interfered other heavy ions, Group I II ions. 1H NMR analysis revealed that two sulfonamide groups played critical role interactions with Hg2+....

A pyrene derivative chemosensor (Pyr-WH) based on a dipeptide shows highly sensitive ratiometric response to Ag(I) as well silver nanoparticles in aqueous solution at physiological pH. Pyr-WH penetrated live HeLa cells and exhibits intracellular Ag(I). The binding mode of with was characterized fluorescence changes different pH, NMR, ESI mass spectrometer experiments.

This communication presents a symmetric fluorescent peptide (Kd = 17.4 nM) for hypersensitively detecting Ag+ in 100% aqueous solution by turn-on response. The penetrated live HeLa cells and detected intracellular

Fluorescent chemosensors (1 and 2, Py-(Arg)nGlyGlyGly(Arg)nLys(Py)-NH2, n = 2 3) bearing two pyrene (Py) labeled heparin-binding peptides were synthesized for the sensitive ratiometric detection of heparin. The peptidyl 2) sensitively detected nanomolar concentrations heparin in aqueous solutions serum samples via a response. In 100% at pH 7.4, both exhibited significant excimer emission 486 nm as well weak monomer absence Upon addition into solution, increased with blue shift (10 nm) 376...

The development of a fluorescence method for the selective ratiometric detection Al3+ ions in pure aqueous solutions and live cells is still significant challenge. In present study, we synthesized new type fluorescent probe using an Al3+-triggered self-assembly based on dipeptide receptor aggregation-induced emission fluorophore. (1) bearing cyanostilbene with excitation by visible light detected sensitively buffered solution red-emission at 600 nm. 1 provided highly among 16 metal solution....

We present a reaction-based fluorescent probe (1) for Hg2+ and CH3Hg+, based on the displacement reaction of arylboronic acid with mercury species. 1 showed promising sensing properties such as high selectivity sensitivity, turn-on response, fast response to (<2 min) CH3Hg+ (<5 min), low detection limits operation in purely aqueous solutions.

A chemosensor (NBD-H) based on an amino acid with 7-nitro-2,1,3-benzoxadiazole was used for selective detection of Hg(II) and Cu(II) among 15 metal ions in aqueous solutions by a colorimetric change. NBD-H sensitively differentiated color change; pink orange Cu(II). showed nanomolar limits (176 nM, R2 = 0.996) (163 0.996). The limit much lower than the maximum allowable level drinking water recommended U.S. EPA. binding mode study that deprotonation NH group played critical role sensing...

An amphiphilic dipeptide (<bold>1</bold>) bearing pyrene and phenylboronic acid was demonstrated as a unique example of ratiometric sensing system for sugars by reversibly converting the peptide aggregates into monomer form complex with in aqueous solutions.

The selective ratiometric red-emission detection of Hg2+ ions in aqueous buffered solutions and live cells is still a significant challenge. In the present study, we synthesized fluorescent probe (1) based on an unnatural peptide receptor containing sulfonamide groups with aggregation-induced emission twisted internal charge transfer (TICT)-active fluorophore, cyanostilbene. 1 exhibited highly response to among 14 metal tested by at 600 nm, clear isoemissive point purely solution 1% DMSO....

The peptidyl bioprobe detected Al(<sc>iii</sc>) ions sensitively in a 100% aqueous buffered solution through ratiometric response.

Tris(pentafluorophenyl)borane, <TEX>$B(C_6F_5)_3$</TEX>, was found to be an efficient catalyst for synthesis of N-Cbzhomoallylic amines using Sakurai allylation N-benzyloxycarbonyl-amino p-tolylsulfones with allyltrimethylsilane.

Silica nanoparticles ( SiNPs ) were synthesized for the detection of heavy metal ions by conjugating a dipeptidyl fluorescent chemosensor DPN into using click reaction. Among 14 tested, conjugated with DPNSi) showed sensitive responses toward Hg( II and Cu( in aqueous solutions. The limits DPNSi determined to be 3.8 16.5 nM ions, respectively, Moreover, sensitivity was significantly higher than that . sufficiently monitoring maximum allowable level drinking water demanded Environmental...