A5085146196- Gestational Diabetes Research and Management
- Diabetes Treatment and Management
- Diabetic Foot Ulcer Assessment and Management
- Diabetes Management and Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Metabolism, Diabetes, and Cancer
- Bariatric Surgery and Outcomes
- Lipoproteins and Cardiovascular Health
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Thyroid Disorders and Treatments
- Peripheral Artery Disease Management
- Pituitary Gland Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Pharmacology and Obesity Treatment
- Vitamin D Research Studies
- Foot and Ankle Surgery
- Heart Failure Treatment and Management
- COVID-19 Impact on Reproduction
- Diabetes and associated disorders
- Bone health and treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Streptococcal Infections and Treatments
- Health Systems, Economic Evaluations, Quality of Life
Royal Brisbane and Women's Hospital
2016-2025
The University of Queensland
2015-2024
Queensland Health
2016-2022
Sunshine Coast University Hospital
2020
Queensland University of Technology
2016-2020
Community Link
2020
Australian Government
2020
Metro South Health
2016
Diabetes Australia
2014
Women's Hospital
2014
Cardiovascular disease (CVD) risk is increased in type 2 diabetes. The purpose of this study was to assess the effect 10 mg atorvastatin versus placebo on CVD prevention subjects with diabetes and LDL cholesterol levels below contemporary guideline targets.Subjects were randomly assigned receive or a 4-year, double-blind, parallel-group study. composite primary end point comprised cardiovascular death, nonfatal myocardial infarction, stroke, recanalization, coronary artery bypass surgery,...
We explored whether cardiovascular disease (CVD) risk and the effects of fenofibrate differed in subjects with without metabolic syndrome according to various features defined by Adult Treatment Panel III (ATP III) type 2 diabetes Fenofibrate Intervention Event Lowering Diabetes (FIELD) study.The prevalence its was calculated. Cox proportional models adjusted for age, sex, CVD status, baseline A1C levels were used determine independent contributions total event rates fenofibrate.More than...
For many years, the diagnosis of diabetes has been made through laboratory-based measurement fasting or random blood glucose levels, using oral tolerance test. A glycated haemoglobin (HbA(1c)) level ≥ 6.5% (48 mmol/mol) is now also acceptable for diagnosing diabetes. Caution needed in interpreting HbA(1c) test results presence conditions affecting red cells their survival time, such as haemoglobinopathies anaemia.
To identify DNA regions important for basal and hormone-stimulated transcription of the rat PRL gene, a series clustered point mutations were prepared within immediate 5′ flanking region. fragments representing wild-type 19 different linker-scanner gene each linked to luciferase marker constructs transferred into GH3 pituitary tumor cells by electroporation. Luciferase activity was determined 24 h after transfection in extracts from control or treated with 0.5 mm chlorophenylthio-cAMP, 100...
Abstract Background Fibrates correct the typical lipid abnormalities of type 2 diabetes mellitus, yet no study, to date, has specifically set out evaluate role fibrate therapy in preventing cardiovascular events this setting. Methods Subjects with diabetes, aged 50–75 years, were screened for eligibility participate a long-term trial comicronized fenofibrate 200 mg daily compared matching placebo assess benefits treatment on occurrence coronary and other vascular events. People total...
Tight glycaemic control reduces the risk of development and progression organ complications in people with type 1 or 2 diabetes. In this position statement, Australian Diabetes Society recommends a general target glycated haemoglobin (HbA1c) level ≤ 7.0% for most patients. This statement also provides guidelines individualisation targets to tighter lesser degree, recommended HbA1c 6.0% some people, up 8.0% others. Individualisation is based on patient-specific factors, such as diabetes its...
Hypercalcemia mediated by 1,25-dihydroxy vitamin D (calcitriol) is uncommon, with evidence on etiology limited to small case series or reports.The objective of the study was systematically identify a large cases calcitriol-mediated hypercalcemia and document presentation, demographics, clinical course across etiologies.The hospital-based, retrospective series, identifying subjects from 1999 through 2009 public hospital system in Queensland, Australia. All patients aged over 18 years were...
Abstract The aims of this study were to investigate the point prevalence, and associated independent factors, for foot disease (ulcers, infections ischaemia) in a representative hospitalised population. We included 733 (83%) 883 eligible adult inpatients across five Australian hospitals on one day. collected an extensive range self‐reported characteristics from participants. examined all participants clinically diagnose amputation procedures. Overall, 72 (9·8%) [95% confidence interval (CI)...
Objective The aims of this point-prevalence study were to investigate a representative inpatient population determine the prevalence people admitted hospital for reason foot-related condition, and identify associated independent factors. Methods Participants adult inpatients in 5 different hospitals, any on day data collection. Maternity, mental health cognitively impaired excluded. surveyed range self-reported demographic, social determinant, medical history, foot disease self-care,...
Glycated haemoglobin (HbA1c) assessment for the diagnosis of diabetes mellitus overcomes many practical problems associated with traditional blood glucose measurements. However, test is not without limitations which medical practitioner needs to be aware. The possibility an individual having a condition that interferes should always considered, even though these conditions are rare in most Australian communities. Appropriately used, HbA1c provide cost-effective, efficient and simple tool...
As more treatments become available to normalize glycated hemoglobin (HbA1c) levels and reduce weight, it is important understand the meaningfulness of achieving target HbA1c weight reduction from perspective people with type 2 diabetes. This a cross-sectional survey 300 Australians Achieving was meaningful 90.0% (n=198) moderately/very/extremely 94.5% (n=208) 220 participants >6.0%. Over half were dissatisfied their current (n=158, 52.7%) underreported body mass index category (n=160,...
Neonatal adiposity is a well-recognized complication of gestational diabetes mellitus (GDM). This study aimed to identify factors influencing in male and female infants women treated for GDM.This was prospective 84 with GDM. Daily blood glucose levels (BGLs) were retrieved from meters, overall mean fasting 2-h postprandial BGLs calculated each woman. Infant body composition measured at birth, regression analysis used significant predictors infant fat separately infants.Maternal BGL the major...
Sex Hormone Binding Globulin (SHBG) is the major serum carrier of sex hormones. However, growing evidence suggests that SHBG internalised and plays a role in regulating intracellular hormone action. This study was to determine whether testosterone uptake, metabolism, action androgen sensitive LNCaP prostate cancer cell line. Internalisation testosterone, effects on regulation responsive genes, growth were assessed. cells by independent process. Testosterone rapidly taken up effluxed as...
Objectives To assess the efficacy and tolerability of risedronate, a pyridinyl bisphosphonate, in preventing loss bone mineral density (BMD) lumbar spine proximal femur early postmenopausal women.Methods A total 383 patients were randomly assigned to receive risedronate 2.5 or 5 mg placebo once daily for 24 months. All received 1 g elemental calcium daily. BMD was measured by dual X-ray absorptiometry at baseline 3, 6, 12, 18, months.Results Risedronate significantly increased femoral neck...
OBJECTIVE: To evaluate the effects of updated gestational diabetes mellitus (GDM) screening and diagnostic criteria on selected perinatal outcomes in Queensland, Australia. METHODS: This was a pre–post comparison study using data year before (2014) after (2016) for GDM changed In 2015, Queensland adopted one-step based International Association Diabetes Pregnancy Study Groups' recommendations. The from 62,517 women 2014 61,600 2016 who gave birth 24 weeks gestation were analyzed three groups...
To determine whether perinatal outcomes after excluding gestational diabetes mellitus (GDM) on the basis of fasting venous plasma glucose (FVPG) assessment during coronavirus disease 2019 (COVID-19) pandemic in 2020 were similar to those preceding year GDM using standard oral tolerance test (OGTT) procedure.Retrospective pre-post study.All women who gave birth Queensland 1 July - 31 December and 2020.Perinatal (maternal neonatal) for pregnant assessed GDM, by method (2019: OGTT/glycated...